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IL6 — MIF

Text-mined interactions from Literome

Hines et al., Vet Microbiol 1999 : MIF-A3 does induce secretion of IL-6 , but does not induce secretion of TNFalpha, IL-1beta, and GM-CSF ... Since IL-6 appears to enhance growth of M. avium and MIF-A3 induces IL-6 secretion, MIF-A3 may be responsible for enhanced intracellular growth in M. avium infections and be a factor in the pathogenesis of M. avium infections
Santos et al., J Rheumatol 2004 (Arthritis, Rheumatoid) : Antagonism of p38 MAP kinase inhibited MIF induction of COX-2, PGE ( 2 ), and IL-6 ... MIF activates RA FLS COX-2 and IL-6 expression via p38 MAP kinase activation and induces IL-8 via p38 and ERK MAP kinase independent pathways
Chagnon et al., Circ Res 2005 (Heart Diseases...) : RNase protection assay (RPA) and Western blot established that MIF neutralization prevented LPS induced mRNA expression and production of heart derived inflammatory paracrine and autocrine cytokines such as IL-1s and IL-6
Herder et al., Diabetes Care 2006 (Diabetes Mellitus, Type 2...) : The associations of MIF with IGT and type 2 diabetes were independent of classical risk factors and of CRP and IL-6 and were much stronger before and after multivariate adjustment than the associations of CRP and IL-6 with IGT and type 2 diabetes
Stojanović et al., Immunology 2009 (Inflammation) : Macrophage migration inhibitory factor stimulates interleukin-17 expression and production in lymph node cells
Balachandran et al., Bioorg Med Chem Lett 2009 : Of note, compounds 7, 22, 23, 24, 25 and 27 inhibited the spontaneous secretion/release/recognition of MIF from freshly isolated human peripheral blood mononuclear cells and, more importantly, inhibited the MIF induced production of interleukin-6 (IL-6) and/or interleukin-1beta (IL-1beta) significantly better than ISO-1
Kim et al., Korean J Intern Med 2010 (Arthritis, Rheumatoid) : MIF was also induced by interferon-?, CD40 ligand, interleukin-15 , interleukin-1ß, tumor necrosis factor-a, and transforming growth factor-ß
Chuang et al., BMC immunology 2010 (Vibrio Infections) : Macrophage migration inhibitory factor regulates interleukin-6 production by facilitating nuclear factor-kappa B activation during Vibrio vulnificus infection ... We conclude that MIF regulates V. vulnificus induced IL-6 production via NF-?B activation and that p38 MAPK activation in V. vulnificus infection is not MIF dependent
Stathas et al., Eur Rev Med Pharmacol Sci 2013 (Nasal Polyps) : MIF attenuates the suppressive effect of dexamethasone on IL-6 production by nasal polyp ... Inhibition of MIF by ( S,R)-3- ( 4-hydroxyphenyl ) -4,5-dihydro-5-isoxazole acetic acid methyl ester ( ISO-1 ), an inhibitor of MIF tautomerase activity, significantly enhanced the dexamethasone suppressive effect on IL-6 production ... MIF , presence in polyp tissue, attenuates the suppressive effect of dexamethasone on the production of IL-6 by this tissue, since the simultaneous use of its inhibitor ISO-1 leads to an enhancement of dexamethasone activity