Gene interactions and pathways from curated databases and text-mining

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MAPK14 — MMP1

Text-mined interactions from Literome

Zhu et al., J Cardiovasc Pharmacol 2000 : Protein kinase C inhibitors, tyrosine kinase inhibitors, and a mitogen activated protein kinase inhibitor significantly inhibited MMP-1 production by cocultures
Xu et al., Biochem J 2001 : Partial inhibition of p38 MAPK activity resulted in the lowest level of MMP-1 expression, whereas total inhibition of p38 activity led to MMP-1 levels as high as in the absence of inhibitor
Schieke et al., J Invest Dermatol 2002 (MAP Kinase Signaling System) : The mitogen activated protein kinase/extracellular signal regulated kinase inhibitor PD 98059, which specifically blocked the extracellular signal regulated kinase pathway, prevented infrared-A induced matrix metalloproteinase 1 expression
Endo et al., Arch Dermatol Res 2003 (Fibrosis...) : p38 mitogen activated protein kinase ( MAPK ) regulates matrix metalloproteinase-1 (MMP-1) gene expression bidirectionally depending on the induction
Utani et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Studies with specific inhibitors of MAPKs showed that p38 MAPK activation was necessary for both IL-1 beta and MMP-1 induction, but Erk activation was required only for MMP-1 induction
Behera et al., Infect Immun 2004 (MAP Kinase Signaling System) : Infection with B. burgdorferi results in rapid phosphorylation of p38 and JNK within 15 to 30 min. Inhibition of JNK and p38 MAPK significantly reduced B. burgdorferi induced MMP-1 and MMP-3 expression
Domeij et al., J Periodontal Res 2004 : Tyrosine kinase inhibitor herbimycin A reduced MMP-1 production induced by PMA, whereas the p38 MAPK-inhibitor SB 203580 synergistically increased the stimulatory effect of PMA on both MMP-1 and TIMP-1 production
Pillinger et al., J Biol Chem 2005 (Inflammation...) : MMP-1 secretion required activation of the MAPK Erk and subsequent protein synthesis but was down-regulated by the alternate MAPK , p38
Dai et al., Ann Rheum Dis 2005 (Arthritis...) : In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1, MMP-3 , and MMP-13, which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor ... In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1 , MMP-3, and MMP-13, which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Song et al., Endocrinology 2007 (Breast Neoplasms) : In noncancer cells, IGF-I initiates a linear process involving activation of the IGF-I receptor (IGF-IR) and matrix metalloproteinases ( MMP ) , release of heparin binding epidermal growth factor ( HB-EGF ), and activation of EGF receptor (EGFR) dependent MAPK
Ancha et al., Int J Biochem Cell Biol 2007 (MAP Kinase Signaling System) : MAPK inhibition also prevented histamine-and HB-EGF induced MMP-1 secretion
Yagi et al., J Gastroenterol 2007 (Colitis) : Inhibitors for ERK ( PD98059 and U0216 ) and p38 MAPK ( SB203580 ) significantly reduced the IL-17F induced IL-6, IL-8, LIF, MMP-1 , and MMP-3 secretion
Bogatkevich et al., Arthritis Rheum 2007 (MAP Kinase Signaling System...) : The MAPK inhibitor, U0126, blocked MMP-1 activity and restored HGF inhibited collagen and CTGF accumulation
d'Abusco et al., Arthritis Res Ther 2007 (MAP Kinase Signaling System) : These findings demonstrate, for the first time, that glucosamine inhibits IL-1beta stimulated MMP production in human chondrocytes by affecting MAPK phosphorylation
Oner et al., J Clin Endocrinol Metab 2008 (Chorioamnionitis...) : Effects of progestin-p38 MAPK signaling inhibition on cytokine enhanced MMP-1 and MMP-3 expression in term DCs suggest alternative mechanisms to prevent CAM induced PTD ... Our objective was to evaluate : 1 ) MMP-1 and MMP-3 expression in decidual sections from uncomplicated term, idiopathic preterm, and CAM complicated deliveries, and 2 ) the separate and interactive effects of IL-1beta, TNF-alpha, medroxyprogesterone acetate ( MPA ), and a p38 MAPK inhibitor ( SB203580 ) on MMP-1 and MMP-3 expression in term decidual cells (DCs)
Uttamsingh et al., Oncogene 2008 (Cell Transformation, Neoplastic) : Among them, the expression of MMP1, MMP3, MMP9 and MMP10 was MAPK dependent ... Among them, the expression of MMP1 , MMP3, MMP9 and MMP10 was MAPK dependent
Ding et al., Osteoarthritis Cartilage 2008 : To define the role of mitogen activated protein ( MAP ) kinases in fibronectin fragment ( Fn-f ) mediated matrix metalloproteinase ( MMP ) upregulation and damage to bovine cartilage and to compare activities of three Fn-fs with native fibronectin ( Fn ), which is inactive in terms of cartilage damage
Nakatani et al., Arch Oral Biol 2009 : Effects of specific inhibitors of p38 mitogen activated protein kinase ( MAPK ) activity, MAPK kinase activity and NFkB activity on HAoligo induced MMP-1 expression in HPDL cells were also investigated by real-time PCR and Western blot analyses
Bhagavathula et al., Invest Radiol 2009 : U0126, an inhibitor of mitogen activated protein kinase signaling, and LY294002, a phosphatidylinositol-3 kinase inhibitor, reduced MMP-1 levels
Santibáñez et al., FEBS Lett 2010 : Furthermore, MMP9 production was MAPK dependent , as the MEK inhibitor PD98059 decreased TGF-beta1 induced MMP9 expression and secretion in Q61LRac1 expressing cells
Chen et al., Invest New Drugs 2011 (Breast Neoplasms) : The MAPK inhibitors effectively prevented the loss of MMP and apoptosis induced by protoapigenone
You et al., Mol Biol Rep 2011 : All the MAPK inhibitors slightly enhanced cell growth inhibition, death and MMP ( d?m ) loss, and increased ROS levels in PG-treated HeLa cells
Park et al., J Dermatol Sci 2011 (MAP Kinase Signaling System) : Then we found that the inhibition of p38 MAPK pathway specifically increased the MMP-1 expression stimulated by EGF but not by TNF-alpha or IL-1beta, indicating that the effect of p38 MAPK on MMP-1 expression may be stimulus-type specific in human skin fibroblasts ... In addition, the inhibitory effect of p38 MAPK on EGF induced MMP-1 expression was shown to be mainly mediated by p38-alpha MAPK ... Our further studies showed that the inhibition of p38 MAPK but not PI3K specifically increased EGF induced ERK and JNK activations, and that the augmentation of EGF induced MMP-1 expression by p38 MAPK inhibition was significantly attenuated by inhibiting the activities of ERK and/or JNK ... Our results indicate that EGF induced MMP-1 expression is differentially regulated by the JNK, p38 MAPK , and PI3K/Akt pathways, and suggest that p38 MAPK negatively regulates EGF induced MMP-1 expression by suppressing the activations of ERK and JNK
Cui et al., Biochem Biophys Res Commun 2012 (Neoplasm Invasiveness) : Subsequent functional validation revealed that K63E and S193A mutants, which disrupted CD147 dimerization both in solution and in living cells, showed clearly dominant negative effects on MAPK activation, MMP2 induction and invasiveness in tumor cells
Lee et al., Biol Pharm Bull 2012 : These findings indicate that macelignan regulates the expression of MMP-1 and type I procollagen in UV-irradiated human skin fibroblasts by modulating MAPK and TGF-ß/Smad signaling, suggesting its potential as an efficacious antiphotoaging agent
Yu et al., Life Sci 2013 (MAP Kinase Signaling System) : Overall, these results demonstrate that cilostazol regulates UVB induced MMP-1 expression and type I procollagen synthesis by inhibiting MAPK signaling and AP-1 activity
Lee et al., J Dermatol Sci 2013 : In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent activation of mitogen activated protein kinase ( MAPK ), ATF-2, and c-Jun, and MMP expression
Green et al., Journal of neuroinflammation 2013 (Tuberculosis) : Monocyte-microglial network dependent MMP-1 and MMP-3 gene expression and secretion are dependent upon p38 MAPK in tuberculosis
Korzus et al., J Biol Chem 1997 : The mitogen activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element mediated activation of matrix metalloproteinase 1 gene expression