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MMP13 — VEGFA

Text-mined interactions from Literome

Tanaka et al., Jpn J Cancer Res 1999 (Adenocarcinoma...) : Since MMP-1, MMP-3 and MMP-9 play important roles in tumor invasion and TGF-beta and VEGF are involved in tumor angiogenesis, hypothemycin is considered to be an example of a new class of antitumor drugs, whose antitumor efficacy can be at least partly attributed to inhibition of Ras-inducible genes
Nayak et al., J Clin Endocrinol Metab 2000 (Substance Withdrawal Syndrome) : Because of reports that VEGF can enhance MMP expression, we hypothesize that VEGF-KDR interactions may influence MMP expression in the superficial zones of the primate endometrium during the premenstrual phase, and that these interactions play a role in the induction of menstruation
Etoh et al., Cancer Res 2001 (Neovascularization, Pathologic...) : MMP-1, MMP-9 , and urokinase-type plasminogen activator in ECs were strongly up-regulated by Ang-2 in the presence of VEGF in vitro
Brenner et al., Ann N Y Acad Sci 2002 (Endometriosis) : A unique role of VEGF at this stage of the cycle may be to stimulate MMP expression in stromal cells because VEGF, KDR, and MMPs were all coordinately induced in these cells in the superficial zone of the primate endometrium by P withdrawal
Hotz et al., J Gastrointest Surg 2003 (Disease Models, Animal...) : Blockade of vascular endothelial growth factor ( VEGF ) and inhibition of matrix metalloproteinases ( MMP ) are promising therapies for cancer ... Both VEGF blockade and MMP inhibition reduce primary tumor size, metastasis, and angiogenesis, thereby increasing survival in experimental pancreatic cancer
Belotti et al., Cancer Res 2003 (Ascites...) : Exogenous, activated MMP9, and, to a lesser extent, MMP2 , increased VEGF release by SKOV3 and OVCAR3 ovarian carcinoma cells
Pufe et al., J Pathol 2004 (Osteoarthritis) : VEGF increased secreted MMP-1, MMP-3 , and especially MMP-13, which could be effectively reduced by an inhibitor of VEGFR-2 kinase activity
Oh et al., Cancer Res 2004 (Melanoma) : First, TIMP-2 can inhibit cell migration after VEGF stimulation by direct inhibition of MMP activity induced in response to VEGF stimulation
Notari et al., Invest Ophthalmol Vis Sci 2005 (Anoxia...) : MMP induction by VEGF was performed in baby hamster kidney ( BHK ) cells
Adya et al., Cardiovasc Res 2008 : Inhibition of VEGFR2 and VEGF [ by soluble FMS-like tyrosine kinase-1 ( sFlt1 ) ] down-regulated visfatin induced MMP induction
Cezar-de-Mello et al., Br J Pharmacol 2008 (Neovascularization, Pathologic) : Because the transcription factor NF-kappaB has been implicated in VEGF mediated MMP expression and EC proliferation, we postulated that ATL-1 might modulate the NF-kappaB pathway and, indeed, ATL-1 inhibited NF-kappaB nuclear translocation
Wang et al., Arterioscler Thromb Vasc Biol 2009 : Therefore, GIT1 mediates VEGF induced matrix metalloproteinase ( MMP ) activation and ECM degradation by regulating podosome formation
Lee et al., Stroke 2009 (Neovascularization, Pathologic) : Both specific and nonspecific inhibition of nitric oxide synthase resulted in similar reductions, suggesting that VEGF stimulated cerebral MMP activity and angiogenesis are predominantly mediated through inducible nitric oxide synthase, a specific nitric oxide synthase isoform mediating inflammatory responses
Kang et al., Clin Exp Pharmacol Physiol 2009 (Diabetes Mellitus, Experimental...) : Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered HIF-1 alpha/VEGF and MMP/TIMP regulation and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes
Woenne et al., Anticancer Res 2010 (Carcinoma, Squamous Cell...) : MMP inhibition blocks fibroblast dependent skin cancer invasion, reduces vascularization and alters VEGF-A and PDGF-BB expression
Lucas et al., Oncogene 2010 (Carcinoma, Squamous Cell...) : HEF1 silencing and overexpression studies revealed a role for VEGF in regulating cell migration, invasion and matrix metalloproteinase ( MMP ) expression in a HEF1 dependent manner
Wang et al., Arch Oral Biol 2012 (Neovascularization, Pathologic...) : Compared to their age matched controls, the protein levels of VEGF and CTGF were higher in 20-week experimental group, and the protein and mRNA levels of CTGF, MMP-9 , and CHM-I increased in the 24-week experimental group ( all P < 0.05 )
Ghosh et al., J Biol Chem 2012 (MAP Kinase Signaling System...) : ETS-1 protein regulates vascular endothelial growth factor induced matrix metalloproteinase-9 and matrix metalloproteinase-13 expression in human ovarian carcinoma cell line SKOV-3 ... In addition, VEGF induced MMP-9 and MMP-13 expression and in vitro cell invasion were significantly reduced after knockdown of ETS-1 gene ... Again, VEGF induced MMP-9 and MMP-13 promoter activities were down-regulated in ETS-1 siRNA transfected cells ... VEGF induced the expression of MMP-2, MMP-9 , and MMP-13 and hence regulated the metastasis of SKOV-3 ovarian cancer cells, and the activities of these MMPs were reduced after inhibition of PI3K/AKT and p38 MAPK pathways
Kudo et al., J Biol Chem 2012 (Head and Neck Neoplasms...) : Interestingly, MMP-13 promoted the secretion of VEGF-A from fibroblasts and endothelial cells
Gao et al., Ann Rheum Dis 2013 (Arthritis, Psoriatic...) : Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8, MMP2 and 9 expressions in RA synovial explants
López-Vaca et al., Comput Math Methods Med 2012 : Experimental evidence has shown that the MMP13 regulates VEGF formation, and it is assumed that VEGF negatively regulates MMP13 formation
Pratheeshkumar et al., PloS one 2012 (Neoplasm Invasiveness...) : Western blot analysis showed that luteolin suppressed VEGF induced phosphorylation of VEGF receptor 2 and their downstream protein kinases AKT, ERK, mTOR, P70S6K, MMP-2 , and MMP-9 in HUVECs
Zucker et al., Int J Cancer 1998 (Neovascularization, Pathologic) : We propose that an early step in tumor angiogenesis involves VEGF induced thrombin generation and increased MMP production with subsequent activation of endothelial progelatinase A and degradation of the underlying basement membrane
Wang et al., Circ Res 1998 : These data suggest the role of flt-1 in mediating VEGF stimulated MMP expression of SMCs