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EPHB2 — MMP14

Text-mined interactions from Literome

Gingras et al., FEBS Lett 2001 (MAP Kinase Signaling System) : Accordingly, MT1-MMP overexpression induced the activation of ERK , this process being also dependent on the presence of its cytoplasmic domain ... MT1-MMP induced activation of both migration and ERK required the catalytic activity of the enzyme as well as attachment of the cells to matrix proteins ... The MT1-MMP dependent activation of ERK was correlated with the activation of transcription through the serum response element, whereas other promoters were unaffected
Sylvester et al., Cell Signal 2004 : ERK pathway inhibitors, PD98059 and U0126, down-regulated IL-17 induced MMP and ADAM-TS4 gene expression
Takino et al., Cancer Res 2004 (MAP Kinase Signaling System) : Expression of a constitutively active form of MEK1 promoted MMP-2 processing concomitant with the increase of MT1-MMP levels, suggesting that MT1-MMP is regulated by MEK/ERK signaling ... In addition, expression of the hemopexin-like domain of MT1-MMP in HT1080 cells interfered with MMP-2 processing, ERK activation, and cell migration, implying that the enzymatic activity of MT1-MMP is involved in collagen induced ERK activation, which results in enhanced cell migration ... Thus, adhesion of HT1080 cells to type I collagen induces MT1-MMP dependent ERK activation, which in turn causes an increase in MT1-MMP levels and subsequent cell migration
Shah et al., Mol Endocrinol 2004 : Agonist mediated MMP activation in C9 cells led to shedding of heparin binding EGF (HB-EGF) and stimulation of ERK1/2 phosphorylation
Purdom et al., J Pharmacol Exp Ther 2005 : In HFs, MMP inhibitors GM6001 [ N- [ ( 2R ) -2- ( hydroxamidocarbonylmethyl ) -4-methylpentanoyl ] -l-tryptophan methylamide ] and BB2516 [ [ 2S- [ N4 ( R ( * ) ) ,2R ( * ) ,3S ( * ) ] ] -N4- [ 2,2-dimethyl-1- [ ( methylamino ) carbonyl ] propyl ] -N1,2-dihydroxy-3- ( 2-methylpropyl ) butanediamide, marimastat ] inhibited JNKs and ERK1/2 activation without affecting p38 activation by H ( 2 ) O ( 2 ) inhibitors
Spallarossa et al., Cardiovasc Res 2006 (MAP Kinase Signaling System) : To investigate the signaling pathways leading to doxorubicin induced MMP activation, we also examined the phosphorylation of three members of the MAPK family ( ERK1/2, p38, and JNK ), the effects of selective inhibitors of ERK1/2 , p38, and JNK on MMP transcription and activity, the transcription of the NAD ( P ) H oxidase subunit Nox1, and the effects of the NAD ( P ) H oxidase inhibitor DPI on MMP activation
Hikita et al., J Biol Chem 2005 : Overexpression of deltaCAPRI or a constitutive active form of Ras up-regulated the expression level of matrix-metalloproteinase 14 (MMP14), which directly cleaves the ectodomain of RANKL, whereas Erk activation by expressing the constitutive active Mek1 did not affect the MMP14 expression or RANKL shedding
Shah et al., J Neurochem 2006 : Phe induced phosphorylation of the EGF-R, and subsequently of Shc and ERK1/2 , was attenuated by inhibition of MMP or HB-EGF with the selective inhibitor, CRM197, or by a neutralizing antibody ... In contrast, phosphorylation of the EGF-R, Shc and ERK1/2 by EGF and HB-EGF was independent of PKC and MMP activity
Takino et al., Exp Cell Res 2006 : Membrane-type 1 matrix metalloproteinase ( MT1-MMP ) plays an important role in extracellular matrix induced cell migration and the activation of extracellular signal regulated kinase ( ERK )
Yang et al., J Pharmacol Exp Ther 2006 (Stomach Ulcer) : rCRAMP also increased EGFR and ERK1/2 phosphorylation via an MMP dependent mechanism
Aitken et al., Am J Pathol 2006 (Mechanotransduction, Cellular) : Similarly, stretching BSMCs in vitro induced increases in ERK1/2 activation and ERK1/2 dependent proliferation under discrete mechanical conditions, and distension conditioned medium itself induced MMP dependent ERK1/2 activation in BSMCs. Overall, stretch induced proliferation and ERK1/2 signaling in bladder tissue and BSMCs likely depend on secreted MMP activity
Meriane et al., Stem Cells 2006 (MAP Kinase Signaling System) : Moreover, MMP- and ROCK dependent molecular events are implicated in the regulation of the S1P induced activation of ERK
Itoh et al., IUBMB Life 2006 : MT1-MMP degrades extracellular matrix to make a path for cells to migrate, sheds cell surface molecules to give migratory signals, and activates ERK ( extracellular signal regulated protein kinase ) enhancing cell migration
Tellier et al., Mol Cell Biol 2007 : Pharmacological and molecular inhibitors of MMPs ( batimastat ), furin ( alpha1-PDX inhibitor transfected SMC ), MT1-MMP ( SMC overexpressing a catalytically inactive MT1-MMP ), MMP2 ( fibroblasts from MMP2 ( -/- ) mice ), and small interfering RNA ( siRNA ) strategies ( siRNAs targeting furin, MT1-MMP, MMP2, and nSMase ) resulted in near-complete inhibition of the activation of nSMase, sphingosine kinase-1, and ERK1/2 and of subsequent DNA synthesis
Kajanne et al., J Cell Physiol 2007 : Moreover, the expression of MMP-3 and -14 , and collagen contraction is partially prevented by Mek/Erk and Jnk inhibitors
Lin et al., J Biol Chem 2008 : This study provides the first evidence that MMP mediated cleavage of EphB2 is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses
Xie et al., Am J Physiol Gastrointest Liver Physiol 2009 (Colonic Neoplasms) : ACh induced MMP1, MMP7 , and MMP10 gene transcription was attenuated by atropine, anti-EGFR antibody, and chemical inhibitors of EGFR and ERK activation
Pan et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2010 : To investigate the effect of ERK signaling pathway and MMP-9 on migration of hPDLC, the cells were incubated with PD98059, a specific extracellular signal regulated kinase ( ERK ) kinase inhibitor, or doxycycline, a MMP inhibitor
Li et al., Phytomedicine 2010 (Hyperplasia) : However, HG-down regulated MT-1 MMP expression was independent of activation of ERK1/2 and Akt when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination
Ta et al., Atherosclerosis 2010 : Taken together, this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and ERK dependent MMP expression by U937 cells, suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling
Dangi-Garimella et al., Cancer Res 2011 (Carcinoma, Pancreatic Ductal...) : Overexpression of MT1-MMP in the collagen microenvironment increases ERK1/2 phosphorylation and HMGA2 expression, and thereby further attenuates gemcitabine induced checkpoint arrest
Williams et al., J Biol Chem 2011 : Intracellular trafficking of MT1-MMP was observed to be coupled to the trafficking of integrin a5 and phosphorylation of ERK that coincided with this was dependent on phosphorylation of MT1-MMP
Mou et al., J Biol Chem 2013 (Brain Neoplasms...) : Meanwhile, inhibition of ERK , JNK, and Akt reduced the MT1-MMP induction
Lee et al., J Biol Chem 2013 (Neoplasm Invasiveness...) : Blockade of p21 ( WAF1 ) function by siRNA reversed migration, invasion, activation of ERK signaling, MMP-9 expression, and activation of NF-?B in IL-20 treated cells