Gene interactions and pathways from curated databases and text-mining

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IL1B — MMP24

Text-mined interactions from Literome

Chubinskaya et al., Lab Invest 1999 : The objectives of this study were the following : ( a ) describe the appearance of histopathologic changes observed in human articular cartilage from the knee and ankle joints of organ donors with no symptomatic joint disease ; ( b ) compare by in situ hybridization mRNA expression of six matrix metalloproteinases ( MMP ) in these cartilages ; ( c ) compare MMP mRNA expression with the histology of the cartilage ; and ( d ) test whether the effect of interleukin-1beta (IL-1beta) on the MMP mRNA expression could be detected with in situ hybridization
Panagakos et al., Biochimie 2000 : IL-1beta and TPA alone induced MMP activity in HIG-82 cells ... A dose dependent inhibition of IL-1beta and TPA stimulated MMP activity by gallium nitrate at increasing concentrations was observed
Siwik et al., Circ Res 2000 : IL-1beta and TNF-alpha each increased total matrix metalloproteinase ( MMP ) activity as measured by in-gel zymography, causing specific increases in the bands corresponding to MMP-13, MMP-2, and MMP-9
Origuchi et al., Clin Exp Rheumatol 2000 (Arthritis, Rheumatoid) : In support of this result, IL-1 beta stimulation induced the expression of membrane type matrix-metalloproteinase ( MT-MMP ), a newly identified MMP-2 specific activator, in rheumatoid osteoblasts
Shlopov et al., J Rheumatol 2001 (Osteoarthritis) : A decrease in IL-1alpha, IL-1beta , and IL-6 would reduce stimulation of MMP production, while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves
Bai et al., Osteoarthritis Cartilage 2001 : In all cases, PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on IL-1beta induction of MMP expression
Ieda et al., Rheumatol Int 2001 (Chondrosarcoma) : IL-1beta induced the expressions of MMP-1, MMP-13 , and GLS mRNAs and proteins in a dose dependent manner
Miyajima et al., Microb Pathog 2001 (Corneal Ulcer...) : Effects of pseudomonal virulence factors [ elastase, alkaline protease, exotoxin A and lipopolysaccharide (LPS) ], tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta on MMP induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ), zymography and immunoblotting
Kolomytkin et al., Am J Physiol Cell Physiol 2002 : IL-1beta produced a dose dependent increase in MMP activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min
Domeij et al., Eur J Oral Sci 2002 (MAP Kinase Signaling System) : In addition, MMP-1 and MMP-3 production, induced by IL-1beta , TNFalpha or EGF, was strongly reduced by the presence of the glucocorticoid dexamethasone
Tsuzaki et al., J Orthop Res 2003 : IL-1 beta induces COX2, MMP-1 , -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells
Lee et al., J Allergy Clin Immunol 2003 (Asthma...) : These results suggest that MMP inhibitors regulate inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4, and TNF-alpha expression
Bamba et al., J Gastroenterol 2003 : In human colonic SEMFs, MMP-3 secretion and MMP-3 mRNA expression were induced by IL-17, IL-1beta , and TNF-alpha
Xie et al., J Biol Chem 2003 : Interleukin-1beta (IL-1beta) , increased in the heart following MI, increases matrix metalloproteinase ( MMP ) activity in cardiac fibroblasts in vitro ... However, it reduces IL-1beta stimulated increases in MMP activity and expression in adult rat cardiac fibroblasts
Kaden et al., Atherosclerosis 2003 (Aortic Valve Stenosis) : As recent studies have suggested that calcific AS might result from an inflammatory process involving leukocyte invasion and activation, the present study aimed to elucidate the role of the pro-inflammatory cytokine interleukin (IL)-1 beta on MMP expression and cell proliferation in human aortic valves
Julovi et al., Arthritis Rheum 2004 : Preincubation with anti-CD44 antibody, which suppressed IL-1beta stimulated MMPs, reversed the inhibitory effect of HA on MMP production that was induced by IL-1beta in normal and OA cartilage ... This study demonstrates that HA effectively inhibits IL-1beta stimulated production of MMP-1, MMP-3 , and MMP-13, which supports the clinical use of HA in the treatment of OA
Yamanaka et al., Clin Cancer Res 2004 (Neoplasm Invasiveness...) : IL-1beta enhanced NF-kappaB activation, MMP-9 expression, and the invasive ability of GCTM-1
Eby et al., Med Hypotheses 2005 (Arthralgia...) : A dose dependent inhibition of IL-1beta and TPA stimulated MMP activity by gallium nitrate at increasing concentrations occurs, demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis
Deschner et al., Osteoarthritis Cartilage 2006 (Mechanotransduction, Cellular) : However, MMP-2 , -11, -14, and TIMPs were not affected by either IL-1beta or tensile strain
Krueger et al., J Biol Chem 2006 : In vitro, MMP-1 is up-regulated by interleukin-1beta and tumor necrosis factor-alpha, but these regulatory mechanisms are not operating in H. pylori infection as shown by inhibitory antibodies
Hiramitsu et al., Rheumatology (Oxford) 2006 (Arthritis, Rheumatoid) : HA at > or =2 mg/ml significantly inhibited MMP production induced by IL-1beta in a dose dependent manner ... Inhibition studies revealed the requirement of NF-kappaB, p38 and c-jun NH2-terminal kinase ( JNK ) for IL-1beta induced MMP production
Klatt et al., Biomed Pharmacother 2006 (Osteoarthritis) : TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha
Fan et al., Rheumatol Int 2006 : Role of mitogen activated protein kinases and NFkappaB on IL-1beta induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human chondrocytes
François et al., Arthritis Rheum 2006 : Inhibition of sIL-1Ra expression by a specific small interfering RNA suppressed the effect of CloF on IL-1beta induced MMP expression
Chung et al., Curr Drug Targets 2006 (Pulmonary Disease, Chronic Obstructive) : TNFalpha and IL-1beta stimulate macrophages to produce matrix metalloproteinase-9 [ MMP-9 ], and bronchial epithelial cells to produce extracellular matrix glycoproteins
Inatomi et al., Pancreas 2007 : In human pancreatic myofibroblasts, MMP-3 secretion and mRNA expression were induced by interleukin (IL)-17, IL-1beta , and tumor necrosis factor (TNF) -alpha, respectively
Burrage et al., Arthritis Rheum 2007 (Arthritis) : SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on interleukin-1beta (IL-1beta) stimulated MMP production and collagen degradation
Yoo et al., Arthritis Rheum 2007 (Disease Models, Animal...) : Cyclosporin A ( CSA ), a Cn inhibitor, inhibited spontaneous and interleukin-1beta stimulated production of NO, MMP-1 , and MMP-3 in chondrocytes
Yagi et al., J Gastroenterol 2007 (Colitis) : Both IL-17A and IL-17F augmented IL-1beta induced secretion of IL-6, IL-8, LIF, MMP-1 , and MMP-3
Tahiri et al., Ann Rheum Dis 2008 : No effect of CS was observed on IL1 beta induced gelatinolytic activity, MMP1 mRNA expression or ADAMTS-4 expression
d'Abusco et al., Arthritis Res Ther 2007 (MAP Kinase Signaling System) : These findings demonstrate, for the first time, that glucosamine inhibits IL-1beta stimulated MMP production in human chondrocytes by affecting MAPK phosphorylation
Tsutsumi et al., Rheumatol Int 2008 : Celecoxib at 100 nM reduced the IL-1beta induced productions of MMP-1, MMP-3 , iNOS, and NO, whereas indomethacin at 100 nM showed no effect
Delbosc et al., Am J Pathol 2008 : DHA significantly decreased VSMC migration/proliferation induced by interleukin-1beta as well as fibrinolytic/MMP activity
Bujak et al., Am J Pathol 2008 (Fibrosis...) : IL-1beta stimulated MMP mRNA synthesis in wild-type, but not in IL-1RI-null cardiac fibroblasts
Noh et al., Rheumatology (Oxford) 2009 (Arthritis, Rheumatoid...) : Cordycepin is a potent inhibitor of IL-1beta induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs
Wang et al., Growth Factors 2009 : Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes
Kimura et al., J Pharmacol Sci 2009 (Osteoarthritis) : IL-1beta induced MMP production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ), p38 kinase, and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase ( MAPK ) family signal transduction molecules
Cheng et al., Obesity (Silver Spring) 2010 (Cardiovascular Diseases) : Post-fat load, circulating levels of WBC, MMP-1 , and MMP-9 increased by 16, 32, and 43 % ( all P < 0.0001 ), with no significant changes in IL-1beta
Suzuki et al., Cytokine 2010 (MAP Kinase Signaling System) : IL-1beta induced MMP production was significantly augmented in the presence of sIL-6R
Sanchez-Guerrero et al., PloS one 2012 : Pharmacologic MMP/ADAM inhibitors and siRNA knockdown prevent IL-1beta induction of Egr-1
Catanzaro et al., J Biol Regul Homeost Agents 2012 : LD-1227 significantly decreased IL-1beta stimulated gene expression and production of TNFalpha, MMP-1 , MMP-13 and Col10A1 in human chondrocytes
DiBattista et al., J Rheumatol Suppl 1995 : MMP-1, MMP-3 , and TIMP-1 expression and synthesis were induced in cultured human synoviocytes with recombinant human interleukin 1 beta in the absence or presence of either chemical inhibitors of protein kinase A and C ( PKA, PKC ), or prostaglandin E2, or cyclic AMP ( cAMP ) mimetics
DiBattista et al., Lab Invest 1994 : We conclude that IL-1 beta stimulates MMP synthesis by activating PKC but not PKA, and that the synthesis of collagenase and stromelysin is discoordinate on a temporal and quantitative basis
Varga et al., Adv Exp Med Biol 1996 : Type I collagen gene expression, and abrogated the effect of IL-1 beta on MMP expression
Pender et al., J Immunol 1998 : Recombinant TNF-alpha and IL-1beta added directly to mucosal mesenchymal cell lines also caused an increase in MMP production, but only the former was inhibited by the TNFR-IgG
Barro et al., Pancreas 1998 : The inflammatory cytokine interleukin-1 beta (IL-1 beta) did not induce MMP or TIMP expression
Deb et al., J Neurosci Res 1999 (Brain Neoplasms...) : A beta, but not interleukin-1beta (IL-1beta) or lipopolysaccharide (LPS), stimulated an active form of MMP-2 in human U87 glioblastoma cells, as well as increased the expression of the well-known activator of MMP-2, membrane-type ( MT ) -MMP
Wassenaar et al., Clin Exp Immunol 1999 : This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when MMP production was up-regulated by IL-1beta and TNF-alpha or down-regulated by IFN-gamma