Gene interactions and pathways from curated databases and text-mining

◀ Back to CA2

CA2 — MSH5

Text-mined interactions from Literome

Desrues et al., Peptides 2005 : The regulation of alpha-MSH release by GABA is mediated by a chloride dependent [Ca2+ ] c increase in frog melanotrope cells
Lamacz et al., J Mol Endocrinol 1988 : Increasing concentrations of calcium ( from 2 to 10 mmol/l ) gave rise to a dose related stimulation of alpha-MSH secretion, whereas reduction of Ca2+ from 2 to 1.5 mmol/l partially inhibited alpha-MSH release ... The direct effect of extracellular Ca2+ on alpha-MSH secretion was confirmed by the dose dependent stimulation of alpha-MSH release induced by the calcium ionophore A23187 ... Nifedipine ( 10 mumol/l ), which was able to block KCl ( 20 mmol/l ) -evoked alpha-MSH release, induced a slight inhibition of basal alpha-MSH secretion, indicating that extracellular Ca2+ levels may regulate alpha-MSH release in part by Ca2+ influx through voltage dependent Ca2+ channels
Jégou et al., Brain Res 1987 : Depolarizing agents such as potassium ( 50 mM ) and veratridine ( 50 microM ), which is known to increase Na+ conductance, significantly stimulated alpha-MSH release in a Ca2+ dependent manner
Warberg et al., Brain Res 1979 : However, in the presence of 2 mM Ca2+ , alpha-MSH release increased with increasing concentrations ( 30-150 mM ) of K+
Galas et al., Mol Cell Endocrinol 1998 : The stimulatory effect of thyrotropin releasing hormone (TRH) on alpha-melanocyte stimulating hormone ( MSH ) secretion from the frog pars intermedia is mediated through the phospholipase C (PLC) pathway but requires extracellular Ca2+