Gene interactions and pathways from curated databases and text-mining

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IL8 — MSH5

Text-mined interactions from Literome

Kiss et al., Inflammation 1999 : SP and CGRP upregulated the IL-8RA mRNA expression in HaCaT cells, but had no influence on their IL-8 production, whereas, alpha-MSH had no effect on either the IL-8 or the IL-8RA mRNA expression in HaCaT cells ... In contrast, alpha-MSH resulted in a time dependent induction of the IL-8 mRNA expression in dermal fibroblasts
Cui et al., Ophthalmic Res 2005 : alpha-MSH inhibited IL-1beta or TNF-alpha stimulated IL-8 and MCP-1 protein levels in the media ... alpha-MSH inhibited IL-8 and MCP-1 expression and protein secretion
Manna et al., Eur J Immunol 2006 (Acute Disease...) : alpha-MSH did not inhibit IL-8 binding in purified cell membrane or affinity purified CXCR ... IL-8 or anti-CXCR Ab protected against alpha-MSH mediated inhibition of IL-8 binding
Fioretti et al., ACS Nano 2010 : However, in the absence of LPS, PGA-alpha-MSH induced IL-8 secretion and proliferation of pulp fibroblasts, whereas free alpha-MSH inhibited this proliferation
Spaccapelo et al., Eur J Pharmacol 2013 (Brain Ischemia...) : NDP-a-MSH increased hippocampus dentate gyrus ( DG ) expression of Wnt-3A, ß-catenin, Sonic hedgehog (Shh), Zif268, interleukin-10 (IL-10) and doublecortin ( DCX ), as detected at days 3, 6 and 10 after the ischemic insult
Hartmeyer et al., J Immunol 1997 : Alpha-MSH ( 10 ( -10 ) -10 ( -8 ) M ) significantly up-regulated IL-8 release and mRNA expression by HMEC-1