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MSX2 — NOTCH4

Text-mined interactions from Literome

Shimizu et al., Arterioscler Thromb Vasc Biol 2009 : The Msx2 gene, a key regulator of osteogenesis, was highly induced by coculture with Notch ligand expressing cells or overexpression of Notch intracellular domains ( NICDs ) in human aortic SMCs ( HASMCs ) ... The RBP-Jk binding element within the Msx2 promoter was critical to Notch induced Msx2 gene expression ... These results imply a new mechanism for osteogenic differentiation of vascular SMCs in which Notch/RBP-Jk signaling directly induces Msx2 gene expression and suggest its crucial role in mediating vascular calcification
Shimizu et al., Int Heart J 2012 (Vascular Calcification) : Furthermore, azelnidipine inhibited the ability of Msx2 to activate the ALP gene, but had no effect on Notch induced Msx2 expression