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IL1B — MUC12

Text-mined interactions from Literome

Yoon et al., Acta Otolaryngol 1999 : Effects of TNF-alpha and IL-1 beta on mucin , lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells ... The aim of this study was to examine whether TNF-alpha, IL-1beta or their combination can increase the secretion of mucin as an indicator of mucous secretion, the secretion of lysozyme as an indicator of serous secretion and the secretion of IL-6 and IL-8 as important cytokines
Kim et al., Mol Pharmacol 2002 : These results suggest a role for PGE ( 2 ) in IL-1beta induced mucin synthesis in NCI-H292 cells ... Furthermore, the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in IL-1beta induced mucin production
Kim et al., J Korean Med Sci 2002 (MAP Kinase Signaling System) : Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells ... This study was designed to investigate the signal transduction pathway of the IL-1beta mediated MUC2 gene expression and mucin secretion in human airway epithelial cells ... In cultured human airway NCI-H292 epithelial cells, the steady state of the mRNA level of MUC2 gene expression and mucin secretion induced by IL-1beta were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ), enzyme immunoassay, and immunoblot analysis ... To observe the signal pathway of the IL-1beta mediated MUC2 gene expression and mucin secretion, we used several specific inhibitors ... PD98059 ( MEK/ERK inhibitor ) suppressed IL-1beta mediated MUC2 gene expression and mucin secretion, while SB203580 ( p38 inhibitor ) did not ... Ro31-8220 ( PKC inhibitor ) inhibited IL-1beta mediated MUC2 gene expression and mucin secretion ... These results suggest that the IL-1beta mediated MUC2 gene expression and mucin secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway, and that PI3K is also involved in the IL-1beta mediated MUC2 gene expression and mucin secretion
Kerschner et al., Otolaryngol Head Neck Surg 2003 : To investigate the role of the inflammatory cytokine interleukin-1beta (IL-1beta) in the regulation of mucin secretion by middle ear epithelia ... IL-1beta upregulates mucin secretion from cultured middle ear epithelial cells in a dose- and time dependent manner
Gray et al., Mol Pharmacol 2004 : Interleukin-1beta induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling
Lappalainen et al., Am J Respir Cell Mol Biol 2005 (Asthma...) : IL-1beta increased the thickness of conducting airways, enhanced mucin production, and caused lymphocytic aggregates in the airways
Kerschner et al., Laryngoscope 2006 : IL-1beta stimulates mucin secretion from middle ear epithelium and its effects can be reversed by IL-1betara
Huang et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010 : These results suggest that IL-1beta may enhance mucin gene expression in cultured human nasal epithelial cells