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MUC17 — TNF

Text-mined interactions from Literome

Fischer et al., Am J Respir Cell Mol Biol 1999 : Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro ... In this study, we investigated potential signaling pathways mediating TNF-alpha induced mucin secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture ... Exogenously applied TNF-alpha ( human recombinant ) stimulated mucin secretion in a concentration dependent manner, with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) ... TNF-alpha increased production of nitrite and nitrate by GPTE cells ; both mucin secretion and cGMP production were attenuated by NG-monomethyl-L-arginine ( 1 mM ), a competitive inhibitor of nitric oxide synthase (NOS), or by the GC-S inhibitor LY83583 ( 50 microM ) ; and mucin secretion in response to TNF-alpha or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) ... Collectively, the results suggest that TNF-alpha stimulates secretion of mucin by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC, and involving activation of NOS, generation of NO, production of cGMP, and activation of PKG
Choi et al., Hepatology 1999 : Exogenous tumor necrosis factor alpha (TNF-alpha) ( 1-10 ng/mL ) did cause a minor increase in mucin secretion by the DGBE cells, but the effect of LPS from E. coli on mucin secretion could not be inhibited by preincubation with a TNF-alpha antibody ( 10 microg/mL )
Yoon et al., Acta Otolaryngol 1999 : Effects of TNF-alpha and IL-1 beta on mucin , lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells ... The aim of this study was to examine whether TNF-alpha , IL-1beta or their combination can increase the secretion of mucin as an indicator of mucous secretion, the secretion of lysozyme as an indicator of serous secretion and the secretion of IL-6 and IL-8 as important cytokines
Lin et al., J Infect Dis 2000 (Otitis Media with Effusion) : Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha : potential cause for mucoid otitis media
Smirnova et al., Cytokine 2000 : TNF-alpha stimulates MUC5AC mucin secretion in a dose dependent manner, with 20 ng/ml producing maximal stimulation
Smirnova et al., Eur Cytokine Netw 2001 : IL-6 and TNF-alpha stimulated MUC5AC and MUC5B mucin secretion in a time dependent manner, both in pre-confluent and post-confluent cells
Kawano et al., Ann Otol Rhinol Laryngol 2002 (Hyperplasia...) : Recent studies demonstrated that tumor necrosis factor alpha (TNF-alpha) , present in human middle ear effusion, stimulated mucin production in vitro and up-regulated mucin gene expression in vivo
Ahn et al., Cell Physiol Biochem 2005 : The molecular mechanisms responsible for TNF-alpha mediated MUC2 intestinal mucin up-regulation in HM3 colon adenocarcinoma cells were analyzed using promoter-reporter assays of the 5'-flanking region of the MUC2 gene
Hauber et al., J Allergy Clin Immunol 2005 (Chronic Disease...) : Niflumic acid and MSI-2216 reduce TNF-alpha induced mucin expression in human airway mucosa ... Unstimulated and TNF-alpha induced mucin expression could be decreased by NFA and MSI-2216
Baginski et al., Am J Respir Cell Mol Biol 2006 (Carcinoma, Mucoepidermoid) : We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC mucin induced by LPS or TNF-alpha in human airway epithelial NCI-H292 cells
Hamada et al., Immunology 1991 : The effects of TNF-alpha on the FC gamma IBS and mucin production could not be attributed to a decreased proliferative rate of the cells, as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected
Blalock et al., Invest Ophthalmol Vis Sci 2008 : TNF induced the release of MUC1, MUC4 , and MUC16 from the HCLE surface
Antonela Antoniu et al., Expert Opin Investig Drugs 2009 : Both LPS and TNF-alpha increased MUC5AC mucin production in vivo and in vitro, respectively, and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene
Clark et al., Dis Markers 1994 (Ovarian Neoplasms) : Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian carcinoma cell lines