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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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IL8 — MUC4

Text-mined interactions from Literome

Smirnova et al., Acta Otolaryngol 2002 (Otitis Media with Effusion) : Dose- ( 2-200 ng/ml ) and time- ( 0-5 days ) response studies of IL-8 induced mucin secretion were carried out ... These results suggest that : ( i ) goblet cells are target cells for the pro-inflammatory cytokines IL-1beta, TNF-alpha and IL-8 and can contribute to the pathogenesis of OME by increasing both the concentration of IL-8 and the secretion of mucin ; and ( ii ) IL-8 stimulates prolonged mucin secretion from goblet cells and may be involved in the maintenance of the disease in the chronic stage
Bautista et al., J Immunol 2009 : IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells ... In this study, the effects of IL-8 on expression of two major airway mucin genes, MUC5AC and MUC5B, were evaluated
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Imbert-Fernandez et al., Exp Eye Res 2011 : However with 24 h TNFa, MUC1/A increased IL-1ß and IL-8 whereas MUC1/B had no effect on cytokine expression