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IL1B — MUC5AC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MUC5AC → IL1B (increases, IL1B Translocation) Baginski et al., Am J Respir Cell Mol Biol 2006*
  Evidence: Figure 1A. After 24 hours, individual treatments of Cigarette smoke extract (CSE), LPS, lipoteichoic acid, TNF and IL1B induced MUC5AC {protein} production (~2-3 fold over control) {in cell media}.

Text-mined interactions from Literome

Koo et al., Exp Lung Res 2002 (Lung Neoplasms) : Here, we demonstrate that the RARalpha antagonist can effectively inhibit IL-1beta induced MUC2 and MUC5AC gene expression and reduce intracellular MUC5AC protein
Kim et al., Mol Pharmacol 2002 : Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells ... Cells activated by IL-1beta showed increased extracellular signal regulated kinase ( ERK ) 1/2 and p38 phosphorylation, and IL-1beta induced MUC2 and MUC5AC production was blocked by the ERK pathway inhibitor PD98059 or the p38 inhibitor SB203580
Song et al., J Biol Chem 2003 (Inflammation...) : Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen activated protein kinases-MSK1-CREB activation in human airway epithelial cells ... However, the mechanisms by which the interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha induce MUC5AC gene expression in normal nasal epithelial cells, and the signal molecules involved, especially in the downstream signaling of mitogen activated protein ( MAP ) kinases, remain unclear
Gray et al., Mol Pharmacol 2004 : The goal of the present study was to elucidate the signaling pathways involved in IL-1beta induced MUC5AC production ... We found that IL-1beta increased cyclooxygenase-2 (COX-2) mRNA expression and prostaglandin ( PG ) E ( 2 ) production and that the COX-2 inhibitor celecoxib suppressed IL-1beta induced MUC5AC production ... We conclude that the induction of MUC5AC by IL-1beta , TNF-alpha, PAF, and LPS involves COX-2- generated PGE ( 2 ), activation of EP2 and/or EP4 receptor ( s ), and cAMP-PKA mediated signaling
Kwon et al., Phytother Res 2009 : Kaempferol and quercetin, essential ingredients in Ginkgo biloba extract, inhibit interleukin-1beta induced MUC5AC gene expression in human airway epithelial cells ... According to our previous study, Ginkgo biloba extract ( GBE ) suppresses IL-1beta induced MUC5AC gene expression in NCI-H292 cells via the ERK and p38 MAPK pathways ... This study sought to identify which ingredients of GBE suppress IL-1beta induced MUC5AC gene expression in NCI-H292 cells and to examine which MAPKs are related to MUC5AC gene suppression for each ingredient
Kim et al., American journal of rhinology & allergy 2009 : [ 6 ] -Gingerol suppresses interleukin-1 beta induced MUC5AC gene expression in human airway epithelial cells ... The present study investigated whether [ 6 ] -gingerol suppresses interleukin (IL)-1 beta induced MUC5AC gene expression in human airway epithelial cells and, if so, examined whether the suppression of MUC5AC gene expression is mediated via the mitogen activated protein kinase ( MAPK ) signal transduction pathway
Fujisawa et al., J Immunol 2009 : Further investigation of the promoter region identified a putative NF-kappaB binding site at position-3594/-3582 in the promoter of MUC5AC as critical for the regulation of MUC5AC expression by both IL-1beta and IL-17A ... We conclude that an NF-kappaB based transcriptional mechanism is involved in MUC5AC regulation by IL-1beta and IL-17A in the airway epithelium