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CA2 — MYL5

Text-mined interactions from Literome

Sakurada et al., Circ Res 2003 : The expression of dominant negative N19RhoA suppressed Ca2+ induced Thr695 phosphorylation of the 110-kDa regulatory subunit of myosin phosphatase and phosphorylation of myosin light chain in VSM cells
Kato et al., Biochem J 1992 : We examined the phosphorylation of exogenous substrates by 80 kDa protein kinase, and histone IIIs and myosin light chain were phosphorylated in a Ca2+/CaM dependent manner
Edelman et al., Brain Res Mol Brain Res 1992 : To determine if the Ca2+/calmodulin dependent enzyme, myosin light chain kinase (MLCK) is involved in the regulation of neural myosin we investigated the presence and localization of MLCK in a variety of neural tissues by immunoblotting and immunocytochemistry
Lokeshwar et al., Cell Biol Int Rep 1992 : These data suggest that Ca2+/calmodulin dependent myosin light chain kinase mediated myosin light chain phosphorylation is necessary for regulating the actomyosin related contractility required for normal platelet function
Sanborn et al., J Soc Gynecol Investig 2005 : An increase in myometrial Ca2+ ( i ) results in phosphorylation of myosin light chain , an increase in myosin adenosine monophosphatase ( ATPase ) activity and contraction
Kitazawa et al., Biochem Biophys Res Commun 1990 : In alpha-toxin permeabilized guinea-pig ileum smooth muscle, a step increase in Ca2+ caused a rapid rise in force and myosin light chain ( LC20 ) phosphorylation, followed by their spontaneous decline to a low steady level even though Ca2+ remained constant
Mackenzie et al., Am J Physiol 1990 : In addition, [ Ca2+ ] i and myosin light chain phosphorylation increased in response to oxytocin and angiotensin II
Rembold et al., J Cardiovasc Pharmacol 1988 : A single regulatory system ( Ca2+ dependent myosin light-chain phosphorylation ) appears to control both mean crossbridge cycling rates ( rate of contraction or shortening velocity ) and the number of attached crossbridges ( stress )
Silver et al., Eur J Pharmacol 1986 : The effects of several antidepressant and antipsychotic agents on Ca2+-calmodulin regulated myosin light chain phosphorylation were evaluated
Hagiwara et al., Mol Pharmacol 1987 : These isoquinolinesulfonamide derivatives should prove to be useful tools for distinguishing between the biological functions of Ca2+ activated, phospholipid dependent, and Ca2+/calmodulin dependent myosin light chain phosphorylation, in vivo
Nakanishi et al., J Biol Chem 1988 : 1 ) K-252a ( 1 x 10 ( -5 ) M ) affected three characteristic properties of chicken gizzard myosin-B, natural actomyosin, to a similar degree : the Ca2+ dependent activity of ATPase, superprecipitation, and the phosphorylation of the myosin light chain
Stull et al., Am J Med Sci 1988 (Second Messenger Systems) : Thus, the Ca2+ dependent phosphorylation of the myosin light chain is a primary event in activation of smooth muscle contraction
Lee et al., Biosci Rep 1987 : In the presence of 1 microM Ca2+ , myosin light chain kinase ( 400 micrograms/ml ) caused an approximately two-fold increase in myosin light chain phosphorylation in digitonin treated cells in 5 min
Bartelt et al., Biochem J 1986 : In the presence of Ca2+ and calmodulin, phosphorylation of smooth-muscle myosin light chain and brain synapsin and autophosphorylation of a Mr-50,000 protein were observed
Edelman et al., J Neurosci 1985 : The association of Ca2+/calmodulin dependent myosin light chain phosphorylating activity with synaptosomal membranes suggests a role for calcium dependent myosin phosphorylation in events relating to neurotransmission
Silver et al., Eur J Pharmacol 1984 : The relative effects of felodipine, a dihydropyridine with purported calmodulin antagonistic properties, have been compared with the calmodulin inhibitor, W-7, for inhibition of Ca2+ dependent force development and direct inhibition of Ca2+-calmodulin mediated arterial myosin light chain phosphorylation and actin-myosin interactions ... In contrast, W-7 ( IC50 4 X 10 ( -5 ) M ) was approximately 5 X more potent than felodipine ( IC50 2 X 10 ( -4 ) M ) in inhibiting Ca2+ dependent myosin light chain phosphorylation or superprecipitation of arterial actomyosin
Masuda et al., Exp Cell Res 1983 : These results agree with a hypothesis that Ca2+-calmodulin dependent phosphorylation of myosin light chain regulates actin-myosin interactions in non-muscle cells
Silver et al., Mol Pharmacol 1984 : It has been proposed that Ca2+ dependent myosin light chain ( P-light chain ) phosphorylation in smooth muscle permits cycling of myosin cross-bridges within myofibrillar elements for muscle shortening, but a second Ca2+ dependent regulatory mechanism is responsible for force generation
Nishikawa et al., J Clin Invest 1982 : The ability of these derivatives to inhibit Ca2+ dependent phosphorylation of 20,000-dalton myosin light chain from platelets correlated well with the magnitude of their binding affinity to calmodulin
Cassidy et al., Pflugers Arch 1980 : The evidence presented suggests the inhibition of Ca2+ activation of tension in skinned smooth muscle preparations by phenothiazines is due to the inhibition of Ca2+ activated phosphorylation of the 20,000 dalton myosin light chain by the endogenous myosin light chain kinase
Nishikawa et al., Nature 1980 : We now present pharmacological evidence that a calmodulin mediated system, such as Ca2+ dependent myosin light chain phosphorylation, also plays an important role in the phenomenon of the release reaction
Daniel et al., Can J Physiol Pharmacol 1995 : Cytosolic Ca2+ levels control myosin light chain phosphorylation and contraction in VSM and activation of NO synthase and phospholipase A2 in ECs to regulate nitric oxide ( NO ) and prostaglandin I2 formation