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CA2 — NACA
Text-mined interactions from Literome
Marfella et al., Diabetes Nutr Metab 2001
(Diabetes Complications...) :
Reduction of Na+/K+-ATPase activity,
inhibition of
Ca2+-ATPase activity, depressed
Na+/Ca2+ exchanger activity, and activation of Na+/H+ antiport may all be implicated
Xu et al., Cell Calcium 2005
:
Both sarcolemmal ( SL )
Na(+)-Ca2+ exchange inhibitors ( amiloride, Ni2+ and KB-R7943 ) and Na ( + ) -H+ exchange inhibitor ( MIA ) as well as SL store operated Ca2+ channel ( SOC ) antagonists ( SK & F 96365, tyrphostin A9 and gadolinium ), unlike SL Ca2+ channel antagonists ( verapamil and diltiazem ),
inhibited the LPA induced increase in [
Ca2+ ] i
Muthuraman et al., Eur J Pharmacol 2008
(Constriction, Pathologic...) :
Amiloride ( 15 mg/kg i.p. ),
Na+/Ca2+ and Na+/H+ exchange inhibitor, and pralidoxime ( 20 mg/kg i.p. ),
Na+/Ca2+ exchange
inhibitor , were administered for 10 consecutive days starting from the day of surgery or vincristine administration
Volkmann et al., Comp Biochem Physiol C 1988
:
8. The
Na+/Ca2+-exchange may under certain experimental conditions be able to
increase Ca2+i to cytotoxic concentrations
DiPolo et al., Biochim Biophys Acta 1993
:
In contrast, when applied internally it drastically reduces the affinity of the Na+/Ca2+ exchanger towards Ca2+i ions without affecting its maximal rate of transport ; in the presence of MgATP the K0.5 for
Ca2+i activation of forward
Na+/Ca2+ exchange increases from 1.5 microM to 95 microM ; likewise the apparent affinity of the Ca2+i stimulation of the reversal exchange decreases 100-fold
Welsh et al., J Appl Physiol 1996
:
L-type Ca2+ channel and
Na+/Ca2+ exchange inhibitors
reduce Ca2+ accumulation in reperfused skeletal muscle
Kirischuk et al., FASEB J 1997
:
Na+/Ca2+ exchanger modulates kainate
triggered Ca2+ signaling in Bergmann glial cells in situ
Dyck et al., J Biol Chem 1998
:
Cytoplasmic Na+ and
Ca2+ regulate the activity of
Na+-Ca2+ exchange proteins, in addition to serving as the transported ions, and protein regions involved in these processes have been identified for the canine cardiac Na+-Ca2+ exchanger, NCX1.1
Fang et al., Am J Physiol 1998
:
Regulation of
Na+/Ca2+ exchange activity by cytosolic
Ca2+ in transfected Chinese hamster ovary cells
Courtemanche et al., Am J Physiol 1998
:
The model AP resembles APs recorded from human atrial samples and responds to rate changes, L-type
Ca2+ current blockade,
Na+/Ca2+ exchanger
inhibition , and variations in transient outward current amplitude in a fashion similar to experimental recordings
Terracciano et al., J Physiol 1998
:
Na+-Ca2+ exchange and sarcoplasmic reticular
Ca2+ regulation in ventricular myocytes from transgenic mice overexpressing the Na+-Ca2+ exchanger