Gene interactions and pathways from curated databases and text-mining

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CA2 — NACA

Text-mined interactions from Literome

Marfella et al., Diabetes Nutr Metab 2001 (Diabetes Complications...) : Reduction of Na+/K+-ATPase activity, inhibition of Ca2+-ATPase activity, depressed Na+/Ca2+ exchanger activity, and activation of Na+/H+ antiport may all be implicated
Xu et al., Cell Calcium 2005 : Both sarcolemmal ( SL ) Na(+)-Ca2+ exchange inhibitors ( amiloride, Ni2+ and KB-R7943 ) and Na ( + ) -H+ exchange inhibitor ( MIA ) as well as SL store operated Ca2+ channel ( SOC ) antagonists ( SK & F 96365, tyrphostin A9 and gadolinium ), unlike SL Ca2+ channel antagonists ( verapamil and diltiazem ), inhibited the LPA induced increase in [ Ca2+ ] i
Muthuraman et al., Eur J Pharmacol 2008 (Constriction, Pathologic...) : Amiloride ( 15 mg/kg i.p. ), Na+/Ca2+ and Na+/H+ exchange inhibitor, and pralidoxime ( 20 mg/kg i.p. ), Na+/Ca2+ exchange inhibitor , were administered for 10 consecutive days starting from the day of surgery or vincristine administration
Volkmann et al., Comp Biochem Physiol C 1988 : 8. The Na+/Ca2+-exchange may under certain experimental conditions be able to increase Ca2+i to cytotoxic concentrations
DiPolo et al., Biochim Biophys Acta 1993 : In contrast, when applied internally it drastically reduces the affinity of the Na+/Ca2+ exchanger towards Ca2+i ions without affecting its maximal rate of transport ; in the presence of MgATP the K0.5 for Ca2+i activation of forward Na+/Ca2+ exchange increases from 1.5 microM to 95 microM ; likewise the apparent affinity of the Ca2+i stimulation of the reversal exchange decreases 100-fold
Welsh et al., J Appl Physiol 1996 : L-type Ca2+ channel and Na+/Ca2+ exchange inhibitors reduce Ca2+ accumulation in reperfused skeletal muscle
Kirischuk et al., FASEB J 1997 : Na+/Ca2+ exchanger modulates kainate triggered Ca2+ signaling in Bergmann glial cells in situ
Dyck et al., J Biol Chem 1998 : Cytoplasmic Na+ and Ca2+ regulate the activity of Na+-Ca2+ exchange proteins, in addition to serving as the transported ions, and protein regions involved in these processes have been identified for the canine cardiac Na+-Ca2+ exchanger, NCX1.1
Fang et al., Am J Physiol 1998 : Regulation of Na+/Ca2+ exchange activity by cytosolic Ca2+ in transfected Chinese hamster ovary cells
Courtemanche et al., Am J Physiol 1998 : The model AP resembles APs recorded from human atrial samples and responds to rate changes, L-type Ca2+ current blockade, Na+/Ca2+ exchanger inhibition , and variations in transient outward current amplitude in a fashion similar to experimental recordings
Terracciano et al., J Physiol 1998 : Na+-Ca2+ exchange and sarcoplasmic reticular Ca2+ regulation in ventricular myocytes from transgenic mice overexpressing the Na+-Ca2+ exchanger