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IL1B — NANOS2

Text-mined interactions from Literome

Balyasnikova et al., J Cereb Blood Flow Metab 2000 : The NOS-2 activity, assessed by nitrite accumulation, was absent from untreated cultures but was induced by interleukin-1beta and interferon-gamma acting synergistically
Igwe et al., Neuroscience 2001 : The signaling mechanisms by which interleukin 1beta regulates NOS-2 and COX-2 genes remain obscure ... The oxidant scavenger pyrrolidine dithiocarbamate abolished interleukin 1beta induced NOS-2 mRNA accumulation and decreased nitric oxide production in a concentration dependent manner, thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA ... Rotenone, another antioxidant that attenuates reactive oxygen species production by inhibiting the mitochondrial electron transport system, failed to inhibit interleukin 1beta induced NOS-2 and COX-2 mRNA encoding transcripts ... However, rotenone inhibited NOS-2 and COX-2 proteins and associated nitric oxide and prostaglandin E ( 2 ) production, respectively, suggesting a posttranscriptional target for interleukin 1beta mediated regulation of NOS-2 and COX-2 gene expression ... These results indicate that not only transcriptional regulation, but also posttranscriptional events are involved in a redox-sensitive regulation of interleukin 1beta induced NOS-2 and COX-2 gene expression in the dorsal root ganglia
Lianxu et al., Osteoarthritis Cartilage 2006 (Osteoarthritis, Knee) : The NF-kappaBp65-specific siRNA inhibited the expression of NF-kappaBp65 and activation of NF-kappaB, reducing significantly the expression of COX-2, NOS-2 and MMP-9 induced by interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in cultured chondrocytes
Finder et al., J Biol Chem 1997 : In contrast, treatment of cells with the inhibitor of protein farnesylation, FTI-277 ( 10 microM ), blocked IL-1beta induced NOS-2 expression at mRNA and protein levels ... The results demonstrate that a farnesylated protein ( s ) mediates IL-1beta induction of NOS-2 , whereas a geranylgeranylated protein ( s ) represses this induction