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FOS — NFATC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → PKC theta (PRKCQ) (transcription, activates) Villalba et al., J Immunol 1999, Macián et al., EMBO J 2000
  Evidence: mutant phenotype, reporter gene
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Iacobelli et al., J Immunol 2000
  Evidence: reporter gene
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/PPARG complex (NFATC1_NFATC2_NFATC3-PPARG) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Yang et al., J Biol Chem 2000
  Evidence: reporter gene
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: Oct-1 (POU2F1) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, activates)
  Duncliffe et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IL-3 (IL3) (transcription, activates) Duncliffe et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → FOS (FOS) (modification, collaborate) Yang et al., J Biol Chem 2000, Chung et al., Mol Pharmacol 2003
  Evidence: reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN) (modification, collaborate)
  Yang et al., J Biol Chem 2000, Chung et al., Mol Pharmacol 2003
  Evidence: reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: GRAIL (RNF128) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Anandasabapathy et al., Immunity 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: FOS (FOS) → NFAT1-c-4/PPARG complex (NFATC1_NFATC2_NFATC3-PPARG) (modification, collaborate)
  Yang et al., J Biol Chem 2000, Chung et al., Mol Pharmacol 2003
  Evidence: reporter gene, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IFN-gamma (IFNG) (transcription, activates) Curtsinger et al., J Exp Med 2003, Curtsinger et al., J Immunol 2005, Teixeira et al., J Immunol 2005, Campbell et al., Transplantation 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → STAT4 (dimer) complex (STAT4) (transcription, activates)
  Curtsinger et al., J Exp Med 2003, Curtsinger et al., J Immunol 2005, Teixeira et al., J Immunol 2005, Campbell et al., Transplantation 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → GM-CSF (CSF2) (transcription, activates) Cockerill et al., Mol Cell Biol 1995, Tokumitsu et al., Biochem Biophys Res Commun 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN) → NFAT1-c-4/PPARG complex (NFATC1_NFATC2_NFATC3-PPARG) (modification, collaborate)
  Yang et al., J Biol Chem 2000, Chung et al., Mol Pharmacol 2003
  Evidence: reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: T-bet (TBX21) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, activates)
  Campbell et al., Transplantation 1996
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4-active complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Jain et al., Nature 1993, Chen et al., Nature 1998
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS complex (FOS-JUN) (modification, collaborate) Jain et al., Nature 1993, Chen et al., Nature 1998
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUN/FOS/NFAT1-c-4-active complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → JUN/FOS complex (FOS-JUN) (modification, collaborate) Jain et al., Nature 1993, Chen et al., Nature 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: EGR3 (EGR3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Safford et al., Nat Immunol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: FOS (FOS) → NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) (modification, collaborate)
  Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: FOS (FOS) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JUN (JUN) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → GM-CSF (CSF2) (transcription, activates) Cockerill et al., Mol Cell Biol 1995, Tokumitsu et al., Biochem Biophys Res Commun 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) (transcription, activates)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: GRAIL (RNF128) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Anandasabapathy et al., Immunity 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: Oct-1 (POU2F1) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, activates)
  Duncliffe et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IL-3 (IL3) (transcription, activates) Duncliffe et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: Interferon receptor/Type I IFN complex (IFNAR1-IFNAR2-IFNA5_IFNA10_IFNA16_IFNA6_IFNA4_IFNA21_IFNA14_IFNA7_IFNA2_IFNA13_IFNA17_IFNA8) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, activates)
  Curtsinger et al., J Immunol 2005, Campbell et al., Transplantation 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IFN-gamma (IFNG) (transcription, activates) Curtsinger et al., J Immunol 2005, Campbell et al., Transplantation 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: EGR2 (EGR2) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Safford et al., Nat Immunol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IL2 (IL2) (transcription, activates) Safford et al., Nat Immunol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/PPARG complex (NFATC1_NFATC2_NFATC3-PPARG) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Chung et al., Mol Pharmacol 2003
  Evidence: reporter gene
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → FOS (FOS) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → FOS (FOS) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: FOS (FOS) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → ICER1 (CREM) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → JUN (JUN) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JNK2 (MAPK9) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Conze et al., J Exp Med 2002, Kim et al., EMBO J 2002, Jain et al., J Immunol 1992
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → FOS (FOS) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → FOS (FOS) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: FOS (FOS) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → p21SNFT (BATF3) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → JUN (JUN) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → FOS (FOS) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → FOS (FOS) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: FOS (FOS) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → ICER1 (CREM) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → JUN (JUN) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → FOS (FOS) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → FOS (FOS) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: FOS (FOS) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → p21SNFT (BATF3) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → JUN (JUN) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) (transcription, activates)
  Jain et al., J Immunol 1992, Jain et al., Nature 1993, Bodor et al., J Biol Chem 1998
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Kwak et al., Exp Mol Med 2006 : However, retrovirus mediated overexpression of c-Fos induced the expression of NFATc1 despite the presence of tanshinone IIA and reversed the inhibitory effect of tanshinone IIA on osteoclast differentiation
Huang et al., Biochem Biophys Res Commun 2006 (MAP Kinase Signaling System) : Interestingly, overexpression of c-Fos restored RANKL induced osteoclast differentiation from and NFATc1 expression in SB203580 treated precursor cells
Yamashita et al., J Biol Chem 2007 : c-Fos induces NFATc1 , but the relationship between NF-kappaB and these other transcription factors in osteoclastogenesis remains poorly understood ... c-Fos expression requires concomitant RANKL or TNF treatment to induce NFATc1 activation in the dKO cells
Kim et al., Cell Signal 2010 : Epigenetic overexpression of CIITA regulates NFATc1 and OSCAR by competing with c-Fos and NFATc1 for CBP/p300 binding sites
Kim et al., J Immunol 2013 (Bone Resorption...) : LC8 inhibited RANKL induced phosphorylation and subsequent degradation of I?Ba, the expression of c-Fos , and the consequent activation of NFATc1 , which is a pivotal determinant of osteoclastogenesis