Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Awad et al., J Med Dent Sci 2002 : Furthermore, pyrrolidine dithiocarbamate ( PDTC ) partially inhibited the IL-1alpha production and completely inhibited NF-kappaB expression by Pam 212 cells
Lentsch et al., Am J Pathol 1998 (Alveolitis, Extrinsic Allergic...) : In the current studies we sought to determine whether TNF-alpha, IL-1beta , the complement system and oxidants contribute to the activation of NF-kappaB in the lung
Guo et al., Inflammation 1999 : Antisense IRAK-2 oligonucleotide blocks IL-1 stimulated NF-kappaB activation and ICAM-1 expression in cultured endothelial cells ... Antisense IRAK-2 ODN inhibited IL-1 induced NF-KB activation and surface expression of ICAM-1 in a concentration ( 1-4 microg ) - and time ( 5-24 h ) -dependent fashion
Li et al., Science 1999 : Mouse embryonic fibroblast cells that were isolated from IKK2-/- embryos showed a marked reduction in tumor necrosis factor-alpha (TNF-alpha)- and interleukin-1alpha induced NF-kappaB activity and an enhanced apoptosis in response to TNF-alpha
Chang et al., Nat Immunol 2009 (Inflammation) : Peli1 was required for TLR3 induced activation of IkappaB kinase (IKK) and its ` downstream ' target, transcription factor NF-kappaB, but was dispensable for IKK-NF-kappaB activation induced by several other TLRs and the interleukin 1 (IL-1) receptor
Yamanaka et al., Clin Cancer Res 2004 (Neoplasm Invasiveness...) : We examined the role of interleukin (IL)-1beta in activation of nuclear factor kappaB (NF-kappaB) and the biological function of activated NF-kappaB in gastric carcinoma cells
Jimi et al., J Biol Chem 1996 : IL-1 also activated NF-kappaB induction in osteoblasts
Luo et al., Toxicol Appl Pharmacol 2008 : Consistently, IL-1beta stimulated both IkappaB-alpha degradation and NF-kappaB translocation into nucleus in these cells
Bourke et al., J Biol Chem 2000 : The present study shows that interleukin-1 (IL-1) causes persistent activation of NF-kappaB in glial cells ... In addition, in vivo overexpression of the various IkappaB isoforms revealed that IkappaB-beta is the only isoform that has the ability to inhibit IL-1 induced NF-kappaB-driven transcription
Leung et al., J Biol Chem 1994 (Leukemia, T-Cell) : The C-terminal region of the type I IL-1R is required for this effect, and deletion of its cytoplasmic domain abrogates the activation of NF-kappa B by IL-1
Huang et al., Nat Immunol 2004 : Furthermore, MEKK3 is crucial for IL-1- and LPS induced activation of NF-kappaB and JNK-p38 but not ERK, indicating that MAPKs are differentially activated during IL-1R-TLR4 signaling
Lin et al., J Pharmacol Exp Ther 2007 (Neuroblastoma) : GLNVA also reduced cyclooxygenase (COX)-2 expression, inhibitor of nuclear factor (NF)-kappaB ( IkappaB)alpha/IkappaBbeta degradation, NF-kappaB activation , and the overproduction of tumor necrosis factor-alpha, interleukin (IL)-1beta , and prostaglandin E2 in BV-2 cells
Li et al., Acta Pharmacol Sin 2006 (Pulmonary Disease, Chronic Obstructive) : Similarly, NAC inhibited the activation of NF-kB induced by TNF- alpha, but had no effect on the activation of NF-kappaB induced by IL-1 ... PDTC significantly inhibited the activation of NF-kappa B induced by TNF- alpha and IL-1
Dunn et al., Glia 2002 (Brain Ischemia) : Analysis of the effects of IL-1 on nuclear translocation of the transcription factor NF-kB revealed that NF-kB became activated in a time dependent manner ... Of particular interest is the finding that IL-1 stimulated activation of p38 MAP kinase and NF-kB in striatal astrocytes exclusively
van't Hof et al., Proc Natl Acad Sci U S A 2000 (Bone Resorption) : Immunohistochemical studies and electrophoretic mobility shift assays performed on bone marrow cocultures from iNOS-deficient mice showed abnormalities in IL-1 induced nuclear translocation of the p65 component of NFkappaB and in NFkappaB-DNA binding, which were reversed by treatment with the NO donor S-nitroso-acetyl penicillamine ... These results show that the iNOS pathway is essential for IL-1 induced bone resorption and suggest that the effects of NO may be mediated by modulating IL-1 induced nuclear activation of NFkappaB in osteoclast precursors
Iwasaki et al., Cytokine 1993 : In both cell lines, IL-1 alpha activated NF-kappa B-like DNA binding activity but in EL-4 6.1 C10 cells the IL-1 alpha concentration sufficient to induce NF-kappa B response was 1000-fold lower than in 70Z/3 cells
Henmi et al., Biochem J 2009 : Although the molecular mechanism for the IL-1 induced activation of NF-kappaB has been well documented, much less is known about the mechanism by which protein phosphatases down-regulate this pathway ... Ectopic expression of PP2Ceta-2 in human embryonic kidney HEK293IL-1RI cells inhibited the IL-1 induced activation of NF-kappaB
Hellweg et al., Ann N Y Acad Sci 2006 : NF-kappaB was activated by TNF-alpha, IL-1beta , PMA, and camptothecin in a dose dependent manner, but not by LPS
Tegeder et al., J Neurosci 2004 (Disease Models, Animal...) : In cell culture experiments, S1627 inhibited interleukin (IL)-1beta stimulated nuclear translocation and DNA binding of NF-kappaB
Lok et al., J Lab Clin Med 2006 (Pre-Eclampsia) : IL-1alpha enhanced the expression of IL-1alpha, IL-2, IL-6, and IL-8 ; nuclear factor of kappa light chain enhancer in B-cells ( NFkappaB ) -1, NFkappaB-2, and NFkappaB-inhibitor ; cyclin dependent kinase inhibitor and monocyte chemotactic protein-1 ; and transiently increased tissue factor expression
Gu et al., J Biol Chem 2003 : Activation of endothelial cell NF-kappaB by interleukin (IL)-1 constitutes an event critical to the progression of the innate immune response ... We found that RelA, essential for NF-kappaB activation by IL-1 , was associated with the NADPH oxidase adapter protein p47(phox) in yeast two-hybrid, coprecipitation, and in vitro binding studies
Tachado et al., Proc Natl Acad Sci U S A 1997 : Both signals collaborate in regulating the downstream NF-kappa B/rel dependent gene expression of interleukin 1alpha , tumor necrosis factor (TNF) alpha, and inducible NO synthase
Kissner et al., PloS one 2011 (Inflammation) : Here we report that human monocytes treated with SEA, SEB, or anti-MHC class II monoclonal antibodies up regulated MyD88 expression, induced activation of NF-kB , and increased expression of IL-1R1 accessory protein, TNF-a and IL-1ß
Ozaki et al., Clin Cancer Res 2007 (Carcinoma, Hepatocellular...) : Vitamin K2 also suppressed the NF-kappaB binding site dependent cyclin D1 promoter activity and suppressed the basal, 12-O-tetradecanoylphorbol-13-acetate ( TPA ) -, TNF-alpha-, and interleukin (IL)-1 induced activation of NF-kappaB binding and transactivation
Debets et al., J Immunol 2001 (Psoriasis) : However, IL-1epsilon activates NF-kappaB through the orphan IL-1R related protein 2 (IL-1Rrp2), whereas IL-1delta, which shows striking homology to IL-1 receptor antagonist, specifically and potently inhibits this IL-1epsilon response
Jue et al., J Korean Med Sci 1999 (Arthritis, Rheumatoid) : The nuclear factor kappaB (NF-kappaB) plays an essential role in transcriptional activation of TNF and IL-1
Wang et al., Mol Biol Rep 2010 : A possible effect of interaction between PhiC31 integrase and TTRAP was highlighted by the fact that PhiC31 integrase inhibited the NFkappaB activation mediated by IL-1 in a dose dependent manner
McKean et al., J Exp Med 1994 : In this report we demonstrate that the transient nature of IL-1 induced NF-kappa B nuclear translocation occurs as a consequence of ligand induced receptor desensitization
Banning et al., Free Radic Biol Med 2004 : VCAM-1-inducibility was abrogated in SMCLOX but not in SMCPHGPx. Accordingly, NFkappaB-driven reporter gene activation by IL-1 was unaffected in SMCPHGPx but abolished in SMCLOX
Takada et al., J Immunol 2003 : BA suppressed NF-kappaB activation induced by TNF, PMA, cigarette smoke, okadaic acid, IL-1 , and H ( 2 ) O ( 2 )
Lee et al., J Biol Chem 1994 : Neither TPA nor IL-1 alpha induced NF-kappa B binding activity, as assessed by electrophoretic mobility shift analysis
Sizemore et al., Mol Cell Biol 1999 : Specific PI3K inhibitors strongly inhibit both PI3K activation and NF-kappaB dependent gene expression but have no effect on the IL-1 stimulated degradation of IkappaBalpha, the nuclear translocation of NF-kappaB , or the ability of NF-kappaB to bind to DNA ... In contrast, PI3K inhibitors block the IL-1 stimulated phosphorylation of NF-kappaB itself, especially the p65/RelA subunit
Tsuruki et al., Biosci Biotechnol Biochem 2007 (Alopecia) : Hence, we suggest that the anti-alopecia mechanisms of intraperitoneally administered fMLP and MMK-1 include activation of NF-kappaB via IL-1 release downstream of the FPRL1 receptor homolog in rats
Didierlaurent et al., Mol Cell Biol 2006 : Activation of interleukin-1 (IL-1) receptor ( IL-1R ), Toll-like receptor 2 (TLR2), and TLR4 triggers NF-kappaB and mitogen activated protein kinase ( MAPK ) -dependent signaling, thereby initiating immune responses
Iwasaki et al., FEBS Lett 1992 : Herbimycin A blocks IL-1 induced NF-kappa B DNA binding activity in lymphoid cell lines ... The mechanism by which interleukin-1 alpha (IL-1 alpha) activates NF-kappa B DNA binding activity is not completely understood ... While it is well established that protein kinase C can activate NF-kappa B, neither protein kinase C nor protein kinase A appears to be critical in the induction of NF-kappa B by IL-1 alpha ... Since a number of growth factors signal via protein tyrosine kinase, in this study we examined a possible involvement of protein tyrosine kinase in the IL-1 alpha induced NF-kappa B ... The results showed that in the murine pre-B cell line 70Z/3 and in the murine T cell line EL-4 6.1 C10 IL-1 alpha induced NF-kappa B was associated with transient increase in protein tyrosine kinase activity ... Pre-treatment of these cell lines with herbimycin A, an inhibitor of tyrosine kinase activity, blocked the IL-1 alpha enhanced protein tyrosine kinase activity and the IL-1 alpha induced NF-kappa B DNA binding activity ... Herbimycin A at concentrations sufficient to block IL-1 alpha induced NF-kappa B did not block the phorbol 12-myristate 13-acetate ( PMA ) -induced NF-kappa B ... The data suggest that IL-1 alpha and PMA activate NF-kappa B by different pathways and that induction of NF-kappa B DNA binding activity by IL-1 might be dependent on protein tyrosine phosphorylation
Li et al., Am J Physiol Cell Physiol 2009 : We conclude that IL-1alpha and IL-1beta act via an oxidant- and AKT/Foxo independent mechanism to activate p38 MAPK, stimulate NF-kappaB signaling, increase expression of atrogin1/MAFbx and MuRF1, and reduce myofibrillar protein in differentiated myotubes
Fisher et al., Gene Ther 2004 : The ability of the transport peptide-PNA-NFkappaB decoy complex to block the effect of interleukin (IL)-1beta induced NFkappaB activation and IL-6 gene expression was analyzed by electrophoretic mobility shift assay and reverse transcriptase-polymerase chain reaction in rat Rinm5F insulinoma cells
Strozyk et al., Oncogene 2006 (Chromosome Breakage) : In contrast, ultraviolet light B ( UVB ) -induced apoptosis is not inhibited but even enhanced upon NF-kappaB activation by interleukin-1 (IL-1)
Mendes et al., J Cell Biochem 2003 : Differential roles of hydrogen peroxide and superoxide in mediating IL-1 induced NF-kappa B activation and iNOS expression in bovine articular chondrocytes ... Taken together, the results obtained indicate that superoxide mediates IL-1 induced I kappa B-alpha degradation and the consequent NF-kappa B activation and iNOS expression in chondrocytes, whereas H ( 2 ) O ( 2 ) does not seem to participate in those IL-1 induced responses
Wesche et al., Immunity 1997 : The C-terminus of MyD88 interacts with the IL-1 receptor and blocks NF-kappaB activation induced by IL-1 , but not by TNF
Benito et al., Ann Rheum Dis 2005 (Disease Progression...) : The inflammatory cell infiltrate, blood vessel formation, and angiogenic factors, NF-kappaB activation , expression of tumour necrosis factor alpha (TNFalpha) and interleukin 1beta (IL1beta) , and the presence of cyclo-oxygenase (COX)-1 and COX-2 were quantified
Batmunkh et al., FEBS Lett 2006 : Western blot analyses and electrophoretic mobility shift assays ( EMSAs ) revealed that IL-1 strongly activated NF-kappaB , which is a likely suppressor of the Epo promoter
de Martin et al., EMBO J 1993 : We describe here that in porcine aortic endothelial cells, either IL-1 alpha , TNF alpha or LPS upregulates an inhibitor of NF kappa B which we refer to as ECI-6
Eng et al., Microvasc Res 2003 : Further supporting NF-kappaB regulation of PDGF-B, activation of NF-kappaB by interleukin (IL)-1beta resulted in increased PDGF-B transcript levels
Renard et al., Biochem Pharmacol 1997 : In this study, we systematically evaluated the influence of glutathione peroxidase, glutathione reductase and catalase on IL-1 induced NF-kappa B activation by analysing the effect of specific inhibitors of these enzymes
Chen et al., Biochem Biophys Res Commun 2003 : Moreover, down-regulation of NKAP by antisense RNA significantly inhibited TNF- and IL-1 induced NF-kappaB activation ... Our findings suggest that NKAP is a novel nuclear regulator of TNF- and IL-1 induced NF-kappaB activation
Nakazato et al., Kidney Int 1998 : IL-1 treatment rapidly induced the binding activity of NF-kappa B ... In contrast, IL-4 did not affect basal and IL-1 induced NF-kappa B activities
Vakkila et al., J Immunol Methods 2004 : IFNgamma amplified IL-1 induced NF-kappaB responses
Funakoshi et al., Biochem Biophys Res Commun 2001 (Glioblastoma) : A MEK inhibitor, PD98059 enhances IL-1 induced NF-kappaB activation by the enhanced and sustained degradation of IkappaBalpha ... In a human glioblastoma cell line, T98G, IL-1 induced NF-kappaB activation was significantly augmented by the pretreatment of a specific MEK inhibitor, PD98059 ... In contrast, ectopic expression of a constitutive activated form of Raf ( v-Raf ) reduced IL-1 induced NF-kappaB activation , and this inhibition was completely reversed by PD98059 ... Interestingly, PD98059 sustained IL-1 induced NF-kappaB DNA binding activity by an electrophoretic mobility shift assay and also IkappaBalpha degradation, presumably by augmenting and sustaining the proteasome activation
Li et al., Molecular vision 2007 : Inhibition of NF-kappaB partially prevented the induction of IL-1alpha , IL-8, and ELAM-1, but not IL-6
Lim et al., Biol Reprod 2013 (Inflammation...) : As expected, IL1B induced NFKB transcriptional activity
Makarov et al., Gene Ther 1997 : In conditionally immortalized human endometrial stromal cells, overexpression of I kappa B alpha prevented both interleukin-1 (IL-1)-inducible degradation of endogenous I kappa B alpha protein and activation of NF-kappa B
Hattori et al., Cardiovasc Res 2002 : Both statins slightly modulated IL-1/IFN induced NF-kappaB activation, which was not associated with their effect on NO production
Bond et al., FEBS Lett 1998 (Inflammation) : NF-kappaB binding was rapidly induced by IL-1alpha or TNF-alpha but was neither induced nor potentiated by bFGF or PDGF
Kanakaraj et al., J Exp Med 1998 : Here we report that IL-1 mediated activation of JNK, p38, and NF-kappaB were all reduced in embryonic fibroblasts deficient in IRAK expression
Nakano et al., Proc Natl Acad Sci U S A 1998 : A previously identified NF-kappaB inducing kinase (NIK), which mediates NF-kappaB activation by TNFalpha and IL-1 , has been demonstrated to activate IKKalpha
Régnier et al., Cell 1997 : Activation of the transcription factor NF-kappaB by tumor necrosis factor (TNF) and interleukin-1 (IL-1) requires the NF-kappaB inducing kinase (NIK)
Lukita-Atmadja et al., Shock 2002 (Endotoxemia...) : Curcuminoids, derived from the plant Curcuma domestica Val., have been shown to be free radical scavengers that suppress the production of superoxide by macrophages and potent anti-inflammatory agents that inhibit the lipopolysacharide (LPS) induced production of tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta , and the activation of nuclear factor (NF)-kappaB in human monocytic derived cells
Lederer et al., J Immunol 1996 : We demonstrate that IL-1 and TNF induce rapid nuclear translocation of p65(RelA) in T cell clones, whereas TCR induced NF-Kappa B activation in Th1 cells is delayed and may be longer in duration
Bird et al., Cytokine 1992 : IL-1 induced NF-kappa B activation was, however, relatively insensitive to inhibition by K252a or quercetin
Weber et al., Am J Physiol Endocrinol Metab 2003 : In previous studies, we have correlated the inhibitory actions of PGJ ( 2 ) on inducible nitric oxide synthase (iNOS) expression and NF-kappaB activation in response to IL-1 with the increased expression of HSP70 ... Using overexpression and antisense depletion, we provide evidence that HSP70 does not mediate the inhibitory actions of PGJ ( 2 ) on IL-1 induced NF-kappaB or IFN-gamma induced STAT1 activation or cytokine stimulated iNOS expression by beta-cells
Rosa et al., Nitric Oxide 2008 (Osteoarthritis, Knee) : To elucidate the role of endogenous inducible nitric oxide ( NO ) on the regulation of NF-kappaB activity in human chondrocytes, we evaluated ( i ) the pattern of expression of the neuronal ( nNOS ) and inducible ( iNOS ) NO synthase isoforms and the basal NF-kappaB activity in normal and osteoarthritic ( OA ) human chondrocytes, ( ii ) the role of cytokines and growth factors in modulating the protein levels of the two NOS isoforms, and ( iii ) the effect of inhibiting endogenous inducible NO production on the ability of interleukin-1beta (IL-1) to induce NF-kappaB activation
Pinteaux et al., J Neurochem 2002 : In comparison, IL-1beta induced the release of PGE2, IL-6 and activated NF-kappaB , p38, JNK and ERK1/2 in mixed glial cultures, but failed to induce any of these responses in microglial cell cultures
Choi et al., Food Chem Toxicol 2010 (Sarcoma) : Moreover, IL-1beta induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) activation were inhibited by luteolin
Islam et al., Mol Endocrinol 2002 : A role for endogenous NF-kappaB in cAMP and IL-1 regulation of SP-A was suggested by findings that dominant negative forms of inhibitor of kappaB reduced binding of type II cell nuclear proteins to TBE and inhibited SP-A expression
Born et al., J Biol Chem 2000 : Neither receptor alone was able to mediate transcriptional activation of NF-kappaB in response to IL-1alpha, IL-1beta , or IL-18
Varga et al., Int Immunol 1999 : Interruption of TCR- or IL-1R stimulated ERK cascade by PD-98059, a specific inhibitor of MAP/ERK kinase (MEK), resulted in partial suppression of nuclear factor of activated T cells activation and in complete inhibition of IL-1 stimulated NFkappaB activation
Sawai et al., Med Sci Monit 2005 (Pancreatic Neoplasms) : EMSA confirmed that IL-1alpha increased DNA binding activity of AP-1 and NF-kappaB
Clifton et al., Int J Med Microbiol 2005 : Thus, while chemokine response early during the infection likely depends on the direct activation of NF-kappaB, subtle autocrine effects of newly synthesized IL-1alpha may contribute , in part, to the control of NF-kappaB activation and chemokine production at later times
Posadas et al., PloS one 2012 (Neuroblastoma) : AAP also induced NFkB p65 activation by phosphorylation and its translocation to the nucleus, where NFkB p65 increased IL-1ß production
Hartupee et al., J Biol Chem 2008 : Interleukin 1alpha induced NFkappaB activation and chemokine mRNA stabilization diverge at IRAK1
Lu et al., Exp Eye Res 2006 (Corneal Ulcer) : IL-1 induced the phosphorylation and degradation of IkappaB-alpha, the nuclear translocation and up-regulation of the DNA binding activity of the p65 subunit of NF-kappaB, and the activation of NF-kappaB in a manner sensitive to sulfasalazine
Jang et al., Biochem Biophys Res Commun 2004 (Adenocarcinoma) : Interestingly, IL-1beta induced nuclear factor-kappaB (NF-kappaB) activation in A549 cells, which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha ... Specifically, IL-1beta induced nuclear translocation of NF-kappaB was in part attenuated by LY294002, but not by GF109203X, SB203580, and SP600125, suggesting PI3K dependent nuclear translocation of NF-kappaB in response to IL-1beta
Wolf et al., Clin Cancer Res 2001 (Carcinoma, Squamous Cell...) : In this study, we examined the role of IL-1alpha in the activation of NFkappaB and AP-1, the expression of proangiogenic cytokine IL-8, and in the survival and proliferation of HNSCC cell lines
Huang et al., J Neurosci Res 2003 (Brain Ischemia...) : Our results demonstrate that NFkappaB phosphorylation is reduced in ICE KO mice, suggesting that ICE or IL-1 are involved in early NFkappaB phosphorylation
Lee et al., Nature 2009 (Alstrom Syndrome...) : Notably, the increased proliferation of basal keratinocytes is counterbalanced by the growth arrest of suprabasal keratinocytes in the stratified epidermis by IL1alpha dependent NFkappaB signalling
Shen et al., Biochem J 2000 : Taken together, these findings indicate that, by using a proteasome dependent mechanism, IL-1beta concomitantly induces NF-kappaB activation and dephosphorylates IL-6 activated STAT1 ; the latter might partly account for the inhibition by IL-1beta of the IL-6 dependent induction of type II acute-phase genes
Sebban-Benin et al., Hum Mol Genet 2007 (Incontinentia Pigmenti) : Mutation of all these ubiquitination sites severely impaired NF-kappaB activation induced by stimulation with IL-1 , LPS, Nod2/RICK or serum/LPA
Hauf et al., J Immunol 2003 (Inflammation) : As a consequence of NF-kappaB suppression, wild-type STEC induces significantly lower mRNA levels of IL-8, IL-6, and IL-1alpha upon prolonged infection periods compared with bacteria lacking EspB
Curran et al., J Biol Chem 2005 (Astrocytoma...) : Using this assay, R ( + ) WIN 55,212-2 strongly inhibited IL-1 activation of NFkappaB ... In addition electrophoretic mobility shift and chromatin immunoprecipitation assays showed that R ( + ) WIN 55,212-2 does not regulate the IL-1 induced nuclear translocation of NFkappaB or the ability of the latter to bind to promoters regulating expression of ICAM-1 and IL-8
Rogler et al., Scand J Gastroenterol 2001 (Colitis, Ulcerative...) : TNF and IL-1 induced NF-kappaB activation
Lee et al., J Immunol 2003 : In contrast, IL-1 beta induced NF-kappa B activity and I kappa B alpha degradation were not affected by BMP-7
Mengshol et al., Arthritis Rheum 2000 (MAP Kinase Signaling System) : We found that IL-1 induction of MMP-13 requires p38 activity, c-Jun N-terminal kinase (JNK) activity and NF-kappaB translocation ... These results suggest that both NF-kappaB and activator protein 1 transcription factors are necessary for IL-1 induction of MMP-13 ... These studies demonstrate, for the first time, that p38, JNK, and NF-kappaB are required for IL-1 induction of MMP-13
Li et al., Proc Natl Acad Sci U S A 2001 : IL-1 induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor associated kinase (IRAK) ... Both the N-terminal death domain and the C-terminal region of IRAK are required for IL-1 induced NFkappaB and JNK activation, whereas the N-proximal undetermined domain is required for the activation of NFkappaB but not JNK ... The phosphorylation and ubiquitination of IRAK deletion mutants correlate tightly with their ability to activate NFkappaB in response to IL-1 , but IRAK can mediate IL-1 induced JNK activation without being phosphorylated
Yang et al., J Cell Physiol 2010 (Arthritis, Rheumatoid) : Moreover, IL-1beta stimulated NF-kappaB p65 translocation was blocked by helenalin, but not by U0126 or SP600125, revealing that MAPKs and NF-kappaB pathways were independent on these responses
Morel et al., J Biol Chem 2002 (Arthritis, Rheumatoid...) : In an alternate pathway, inhibition of IL-1 receptor associated kinase-1 (IRAK) with AS ODN to IRAK reduced IL-18 induced expression of nuclear factor kappaB (NFkappaB)
Kamthong et al., Biochem J 2001 : We have recently reported that interleukin-1alpha (IL-1alpha) can induce human macrophage colony stimulating factor ( M-CSF ) expression through nuclear factor kappaB (NF-kappaB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated the NF-kappaB activation as well as M-CSF expression
Yanagisawa et al., Biochem J 2003 : These results also indicate that this novel variant may play roles in the activation of NF-kappaB and JNK by IL-1 and other ligands whose signal transduction is dependent on IRAK-1 under physiological conditions
Yamazaki et al., Science signaling 2009 : Although transforming growth factor-beta activated kinase 1 ( TAK1 ) and mitogen activated protein kinase ( MAPK ) kinase kinase 3 ( MEKK3 ) are both crucial for IL-1 dependent activation of NF-kappaB , their potential functional and physical interactions remain unclear
Koul et al., J Biol Chem 2001 : The ability of interleukin-1 (IL-1) to induce inhibitor ( IkappaB ) degradation or nuclear translocation of NFkappaB was, however, unaffected by MMAC/PTEN expression, suggesting that PI 3-kinase utilizes another equally important mechanism to control NFkappaB activation ... Moreover, IL-1 induced phosphorylation of p50 NFkappaB was potently inhibited in MMAC/PTEN expressing cells
Chaturvedi et al., Lymphokine Cytokine Res 1994 : Only TNF, LT, and IL-1 activated NF-kappa B
Tanaka et al., Curr Drug Metab 2010 : We found that either UVB, IL-1 or TNFalpha could induce NF-kappaB by activating its signal transduction pathway
Takii , Yakugaku Zasshi 2001 : This up-regulation leads to the increasing susceptibility of IL-1RI to IL-1, as the DNA binding of IL-1 induced NF-kappa B and the production of IL-1 induced IL-6 from the fibroblasts are augmented by pretreatment with IFNs
Kiss et al., J Neurochem 2005 : IL-1 activated NF-kappaB complexes consisted of p65 and p50, with p65 transiently phosphorylated on serine 536 in glial cells whereas more persistently in hepatic cells
Wilson et al., Gastroenterology 1999 : In contrast, IL-1beta induced NF-kappaB activation was associated with the disappearance of IkappaBalpha and was inhibited by ALLN but not staurosporine
Stalińska et al., J Physiol Pharmacol 2005 : We used human hepatoma ( HepG2 ) and human umbilical vein endothelial cells ( HUVEC ) as a model system : NF-kappaB and AP-1 were activated by the proinflammatory cytokine IL-1 in the absence or presence of 21 selected plant extracts and the effect was evaluated by the electrophoretic mobility shift assay ( EMSA ) ... In both types of cells activation of NF-kappaB by IL-1 was significantly inhibited by extracts from Scandix australis and Artemisia alba, whereas extracts from Amaranthus sp., Eryngium campestre, Thymus pulegioides and Reichardia picroides elicited cell-type dependent response
Wang et al., Am J Physiol Lung Cell Mol Physiol 2005 : As expected, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha were blocked by helenalin but not by U0126, SB-202190, or SP-600125
Nguyen et al., J Interferon Cytokine Res 2003 : Chemical inhibitors or dominant negative forms of signaling components required to activate NF-kappa B , ATF, or AP-1 in response to IL-1 do not affect the phosphorylation of Stat1 on serine
Burns et al., J Biol Chem 1998 : MyD88 induced NF-kappaB activation is inhibited by the dominant negative versions of TRAF6 and IRAK, which also inhibit IL-1 induced NF-kappaB activation ... Overexpression of MyD88-lpr or MyD88-Toll ( expressing only the Toll domain ) acted to inhibit IL-1 induced NF-kappaB and JNK activation in a 293 cell line overexpressing the IL-1RI
Mori et al., Blood 1996 (Bone Resorption...) : Moreover, deletion of either 5 ' or 3 ' NF-kappaB sites reduced IL-1alpha promoter activity in MT-2 cells and transactivation of the IL-1alpha promoter by exogenous NF-kappaB and Tax in Jurkat cells
Kang et al., Toxicol Appl Pharmacol 2001 : The objective of this study was to determine whether ZnTMPyP exhibited the ability to inhibit the production of reactive oxygen species ( ROS ), the activation of NF-kappaB , or the secretion of IL-1 in RAW 264.7 cells, and whether such inhibitory activity was related to the ROS scavenging ability of ZnTMPyP
Griffin et al., J Biol Chem 2006 (Astrocytoma...) : Persistent activation of the transcription factor is seen in numerous chronic inflammatory disease states, and we have previously demonstrated sustained activation of NFkappaB in human glial cells upon stimulation with interleukin (IL)-1beta ... These studies thus demonstrated that persistent IL-1 signaling causes sustained activation of NFkappaB in a promoter-specific manner in human glial cells, leading to prolonged induction of selective pro-inflammatory genes
Wang et al., Invest Ophthalmol Vis Sci 1999 : TNF-alpha, IL-1beta , and TII but not IFN-gamma alone caused degradation of I kappaB, Rel A nuclear translocation, and increased NF-kappaB DNA binding activity, effects that were blocked by pretreatment with MG-132
Gan et al., J Cell Sci 2009 : Here, we show that HSCARG is involved in the NF-kappaB signaling pathway and find that HSCARG suppresses TNF- and IL1 induced NF-kappaB activation in a dose dependent manner
Kidd et al., Neurogastroenterol Motil 2009 (Crohn Disease) : We examined whether interleukin (IL)1beta and Escherichia coli lipopolysaccharide (LPS) induced EC cell 5HT release through Toll-like/IL-1 (TIL) receptor activation, nuclear factor kappa B (NFkappaB) and mitogen activated protein kinase ( MAPK ) phosphorylation and evaluated whether somatostatin could inhibit this phenomenon
Brennan et al., Biochim Biophys Acta 1995 : The results from this study therefore suggest that the reactive oxygen model of NF kappa B activation may be restricted to certain cell types and that the presence of such a system is not required for the activation of NF kappa B by IL1 and TNF
Funakoshi-Tago et al., Eur J Biochem 2003 : We found that IL-1 mediated c-Src activation was required for AP-1 activation, but not for NF-kappa B activation and also revealed that c-Src induced AP-1 activation was enhanced synergistically by the coexpression of TNF receptor associated factor 6 (TRAF6)
Takahashi et al., Atherosclerosis 2002 : In addition, IL-1beta induced NF-kappaB activation in VSMC, an effect that was increased by the addition of beta-VLDL
Kayal et al., Mol Microbiol 2002 : Although a delayed kinetics of LLO dependent NF-kappaB activation suggests an autocrine or paracrine IL-1 dependent pathway, we found that LLO dependent NF-kappaB activation did not require the IL-1 protein synthesis nor the interaction with the IL-1RI specific receptor
Reddy et al., Proc Soc Exp Biol Med 1998 : These data reveal that collagenase gene expression can be regulated by the impairment of IL-1 stimulated NF-kappaB , STAT3, and AP-1 activities, and can highlight a possible molecular mechanism for the anti-inflammatory effects of glucocorticoids
Akhtar et al., BMC complementary and alternative medicine 2011 (Osteoarthritis) : The inhibitory effects of HLM were mediated by inhibiting the activation of nuclear factor (NF)-kB in human OA chondrocytes in presence of IL-1ß
Mifflin et al., Am J Physiol Cell Physiol 2002 (Colitis) : In contrast to what occurs in other cell types, including other myofibroblasts such as renal mesangial cells, PKC inhibition did not prevent IL-1 induced NF-kappaB or mitogen activated protein kinase/ stress activated protein kinase activation, suggesting a novel role for PKC isoforms during this process
Chabane et al., Osteoarthritis Cartilage 2008 : Finally, we demonstrate that the DNA binding activity of NF-kappaB , was induced by IL-1 , but was not affected by treatment with HDAC inhibitors
Cohen et al., Immunobiology 1995 : The LPS or IL-1 induced NF-kappa B binding activity was increased in the presence of MDP but not of MDP ( D, D )
Jimi et al., J Immunol 1999 : sODF, as well as IL-1 , activated NF-kappaB and c-Jun N-terminal protein kinase (JNK) in OCLs
Lee et al., Eur J Immunol 1998 : ROI have been implicated in the activation of NF-kappaB as well as c-Jun N-terminal kinase (JNK) in response to IL-1 and TNF-alpha stimulation
Lu et al., Mol Immunol 2008 : It thus activates downstream signaling events to activate transcription factor NF-kappaB , and induce the expression of IL-1 responsive genes such as TNF-alpha and GM-CSF
O'Neill , Int J Clin Lab Res 1995 : Attention has also been focussed in the activation of the transcription factor NF kappa B , which is rapidly activated by IL1
Cenni et al., Biochem J 2003 : We also demonstrate that Akt activity is necessary for IL-1 dependent NF-kappaB transactivation, since a kinase-defective mutant of Akt impairs IRAK2- and MyD88 dependent, but not IRAK1 dependent, NF-kappaB activity, as monitored by a gene reporter assay
Chen et al., J Biol Chem 2002 : In human embryonic kidney 293 cells, IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation, NF-kappaB transactivation, and weak Akt activation ... However, IL-1beta induced NF-kappaB activity is attenuated by increased intracellular calcium in response to ionomycin, UTP, or thapsigargin or by overexpression of CaMKKc and/or Akt
Chen et al., J Biol Chem 2009 : IL-1 stimulation of the individual IL-1R1 proteins resulted in the activation of NF-kappaB
Sharma et al., J Appl Physiol 2001 : Constitutive and interleukin (IL)-1beta stimulated NF-kappaB activation was significantly greater ( P < 0.05 ) in VSM cells from aged compared with young female rats
Sabolek et al., Stem Cells 2009 (MAP Kinase Signaling System) : Surprisingly, IL-1beta did not activate the NF-kappaB pathway or the transcription factor activating protein 1 (AP-1), but inhibition of nuclear translocation of NF-kappaB by SN50 facilitated IL-1beta induced Nurr1 expression and dopaminergic differentiation of mdNPCs
Roshak et al., J Pharmacol Exp Ther 1997 (Arthritis, Rheumatoid) : Direct action of hymenialdisine on IL-1 induced NFkappaB activation was demonstrated by a significant reduction ( approximately 80 % ) in NFkappaB binding to the classical kappaB consensus motif ( as assessed by electrophoretic mobility shift assay ) and inhibition of stimulated p65 migration from the cytosol of treated cells ( as assessed by Western analysis )
Jimi et al., J Biol Chem 1998 : An electrophoretic mobility shift assay showed that IL-1 transiently activated NF-kappaB in the nuclei of the OCLs, and the maximal activation occurred at 30 min ... The pretreatment of purified OCLs with proteasome inhibitors suppressed the IL-1 induced activation of NF-kappaB and prevented the survival of OCLs supported by IL-1
Shin et al., J Biol Chem 1996 : .NO donors had no inhibitory effect on IRF-1 activation but did inhibit basal and IL-1 alpha stimulated NF-kappa B activation
Bomsztyk et al., J Biol Chem 1990 : Although Bt2cAMP or PGE2 when used alone had no effect, they did consistently modify the level of NF-kappa B activity induced by IL-1 alpha ... Such a regulatory role is supported by the observation that cAMP modulates the IL-1 alpha induced NF-kappa B activity
Zhang et al., Molecular vision 2009 : Furthermore, BOL-303242-X inhibited IL-1ss induced decreases in IkappaB-alpha levels, as well as IL-1ss induced phosphorylation of NFkappaB , p38, and c-Jun-N-terminal kinase (JNK) MAPKs in HCEpiCs
Peters et al., Mol Cell 2000 : A dominant negative mutant of IKKepsilon blocks induction of NF-kappaB by both PMA and activation of the T cell receptor but has no effect on the activation of NF-KB by TNFalpha or IL-1
Dreikhausen et al., Eur J Immunol 2001 (MAP Kinase Signaling System) : UDP-monoglucosylation and concomitant inactivation of Rho A and of Rac-2 by Clostridium difficile toxin B also inhibited IL-1 induced activation of JNK and p38 MAPK, but additionally inhibited activation of the extracellular-regulated-kinase pathway and DNA binding of the transcription factor NFkappaB
Schwenger et al., Mol Cell Biol 1998 : Activation of NF-kappaB by TNF and IL-1 is initiated by the phosphorylation of the inhibitory subunit, IkappaB, which targets IkappaB for degradation and leads to the release of active NF-kappaB
Tanaka et al., J Pharmacol Exp Ther 2005 : We found that UVB, IL-1 , and TNFalpha induced NF-kappaB activation and then produced MMP-1 and bFGF in HaCaT keratinocytes and skin fibroblasts
Jones et al., J Immunol 2005 (Pneumonia, Pneumococcal) : Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia
Frobøse et al., Mol Endocrinol 2006 : Although a great deal is known about the mechanism of activation of NFkappaB and MAPKs by IL-1 , much less is known about the down-regulation of this pathway ... Suppressor of cytokine signaling (SOCS)-3 was shown to inhibit IL-1 induced transcription and activation of NFkappaB and the MAPKs JNK and p38, but the mechanism is unknown
Kuno et al., Int Immunol 1994 (Niemann-Pick Diseases) : Furthermore, activation of NFkB was also induced in NPD type A fibroblasts in response to IL-1 alpha and TNF-alpha stimulation to a similar extent as in normal fibroblasts
Sanz et al., EMBO J 2000 : Here we demonstrate that the inhibition of the aPKCs or the down-regulation of p62 severely abrogates NF-kappaB activation by IL-1 and TRAF6, suggesting that both proteins are critical intermediaries in this pathway
Kanamori et al., FEBS Lett 2002 : Act1 mediated NF-kappaB activation was inhibited by a dominant negative mutant of TRAF6 in a dose dependent manner, and IL-1 induced NF-kappaB activation was inhibited by a high level of Act1 expression
Chen et al., Oncogene 2006 (Multiple Myeloma) : We found that siRNA targeting the TRAF6 C-terminal ( siTRAF6C ) receptor interaction domain specifically reduced only TRAF6 protein expression, without affecting TRAF2 or 5 levels, and substantially interfered with IL-1 induced NF-kappaB and c-Jun/AP-1 activation
Carroll et al., J Immunol 2005 (Inflammation) : In contrast, only MyD88delta was found to inhibit IL-1 induced NF-kappaB reporter activity
Hong et al., FEBS Lett 2001 : CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1 induced NF-kappaB activation
Choi et al., Int Immunopharmacol 2006 : Gel shift assays showed that LY294002 ( LY29 ) potently increased interleukin (IL)-1 induced NF-kappaB DNA binding in human monocytic THP-1 cells ... Moreover, another PI3K inhibitor 3-methyladenine also strongly enhanced IL-1 induced NF-kappaB DNA binding, while LY303511, an inactive analogue of LY29, did not increase the NF-kappaB DNA binding
Luo et al., Toxicol Appl Pharmacol 2009 (Second Messenger Systems) : Moreover, IL-1beta stimulated NF-kappaB and CaMKII phosphorylation through MyD88 dependent PI-PLC/PKCalpha/c-Src/ROS and PI-PLC/Ca2+/CaM pathways, respectively
Joshi-Barve et al., J Biol Chem 1993 (Melanoma) : Using gel retardation and transient expression assays, we show that IL-1 causes protein tyrosine phosphorylation dependent activation of NF-kappa B enhancer binding protein, which then induces transcription of the gro-genes via an NF-kappa B site located 76 base pairs upstream from the cap site
Rameshwar et al., J Immunol 2000 (Primary Myelofibrosis) : The results indicate that IL-1 is necessary for TGF-beta production in IMF monocytes, but NF-kappaB activation is required for the production of endogenous IL-1
Feng et al., Mol Cell Biol 2005 : A prominent function of p62 is the regulation of NF-kappaB activation in response to interleukin-1 (IL-1) and tumor necrosis factor signaling through the formation of an aPKC/p62/TRAF6 multiprotein signaling complex ... Ajuba null mouse embryonic fibroblasts ( MEFs ) and lungs were defective in NF-kappaB activation following IL-1 stimulation, and in lung IKK activity was inhibited ... We propose that Ajuba is a new cytosolic component of the IL-1 signaling pathway modulating IL-1 induced NF-kappaB activation by influencing the assembly and activity of the aPKC/p62/TRAF6 multiprotein signaling complex
Tian et al., J Biol Chem 2007 : The NZF domains of TAB2/3 are critical for TAB2/3 to bind to Lys ( 63 ) -linked polyubiquitin chains of other adaptor proteins, such as receptor interacting protein and TRAF6, which are two signaling proteins essential for TNF- and IL-1 induced NF-kappaB activation, respectively ... Overexpression of RBCK1 negatively regulates TAB2/3 mediated and TNF- and IL-1 induced NF-kappaB activation, whereas knockdown of RBCK1 by RNA interference potentiates TNF- and IL-1 induced NF-kappaB activation
Shimada et al., J Pharmacol Exp Ther 1999 : NF-kappaB activation in response to TNF-alpha, IL-1beta , phorbol ester, and H ( 2 ) O ( 2 ) was down-regulated by polaprezinc
Matthews et al., Cytokine 1999 (Thymoma...) : Neither PD98059 nor SB203580 had an inhibitory effect on NFkappaB-driven reporter gene expression in response to IL-1
Liang et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : Furthermore, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha was blocked by helenalin
Hu et al., J Neurochem 2005 (Disease Models, Animal...) : We used a 7-day-old rat model to elucidate the role of nuclear factor-kappaB (NF-kappaB) activation in HI stimulation of IL-1 signaling ... The observed increase in cytoplasmic phosphorylated inhibitor kappaBalpha ( IkappaBalpha ) and nuclear translocation of Bcl-3 24 h after HI was also significantly attenuated by IL-1Ra blockade, suggesting that HI-induced IL-1 activation of NF-kappaB is via both the degradation of IkappaBalpha and the nuclear translocation of Bcl-3
Mamidipudi et al., J Biol Chem 2004 : Mutation of Thr66 to Ala impaired the autokinase activity of IRAK and reduced its association with iota PKC but not TRAF6, resulting in impaired NGF- as well as IL-1 induced NF-kappaB activation
Mendes et al., Inflamm Res 2002 : SNAP inhibited IL-I induced NF-kappaB activation and NOS II expression
Guo et al., Acta Pharmacol Sin 2000 : To study the inhibitory effects of antisense interleukin-1 receptor associated kinase-2 ( IRAK-2 ) oligodeoxynucleotide ( ODN ) on interleukin-1 (IL-1) stimulated nuclear factor-kappa B (NF-kappa B) activation ... ( 2 ) Antisense IRAK-2 ODN inhibited IL-1 induced NF-kappa B activation in a concentration ( 1-8 micrograms ) - and time ( 5-24 h ) -dependent manner ... Antisense IRAK-2 ODN inhibited IL-1 induced NF-kappa B activation
Islam et al., Mol Cell Biol 2006 : Interleukin-1 (IL-1) stimulation of SP-A expression is mediated by NF-kappaB ( p65/p50 ) activation and increased binding to the TBE
Bond et al., Cardiovasc Res 2001 : IL-1alpha potently activated NF-kappa B in VSMCs and acted synergistically with growth factors to upregulate expression of MMP-1, -3 and -9
Kamthong et al., Biochem J 2000 : Electromobility shift assays showed that IL-1alpha predominantly activated nuclear factor kappaB (NF-kappaB) , while PMA preferentially activated activator protein-1 (AP-1)
Bergmann et al., J Biol Chem 1998 : However, IL-1beta induced IkappaBalpha degradation as well as NF-kappaB nuclear translocation and DNA binding, as determined by Western blot and electro-mobility shift assay, respectively, are not affected by these inhibitors
Mendes et al., Nitric Oxide 2002 : Role of mitogen activated protein kinases and tyrosine kinases on IL-1 Induced NF-kappaB activation and iNOS expression in bovine articular chondrocytes ... These responses to IL-1 were also inhibited by treatment of the cells with the tyrosine kinase inhibitors, genistein and tyrphostin B42, which also prevented IL-1 induced NF-kappaB activation ... The p38MAPK inhibitor, SB 203580, had no effect on IL-1 induced NF-kappaB activation ... In conclusion, this study shows that ( 1 ) PTK are part of the signaling pathway that leads to IL-1 induced NF-kappaB activation and iNOS expression ; ( 2 ) the p38MAPK cascade is required for IL-1 induced iNOS expression ; ( 3 ) the p42/44MAPK and AP-1 are not involved in IL-1 induced iNOS expression ; and ( 4 ) NF-kappaB and the p38MAPK lie on two distinct pathways that seem to be independently required for IL-1 induced iNOS expression
Heyninck et al., FEBS Lett 1999 : The cytokine-inducible zinc finger protein A20 inhibits IL-1 induced NF-kappaB activation at the level of TRAF6 ... Expression of A20 potently inhibits IL-1 induced NF-kappaB activation by an unknown mechanism ... Inhibition of IL-1 induced NF-kappaB activation was found to be mediated by the C-terminal zinc finger containing domain of A20 ... More importantly, we present evidence that A20 interferes with IL-1 induced NF-kappaB activation at the level of TRAF6, upstream of NIK
Gross et al., J Clin Immunol 1993 (Carcinoma, Squamous Cell...) : In contrast, NF-kB was increased by both IL-1 and PMA, but only the effect of PMA, and not that of IL-1, was inhibited by staurosporine
Morelock et al., Assay Drug Dev Technol 2005 : The NF kappaB antagonist assay ( inhibition of IL-1- induced NF kappaB translocation ) data were collected on a Q3DM ( San Diego, CA ) EIDAQtrade mark 100 high throughput microscopy system
Barchowsky et al., Cytokine 2000 (MAP Kinase Signaling System) : Although both IL-1 and TNF activate NF-kappaB in these cells, only IL-1 induces collagenase-1 transcription
Peng et al., Zhonghua Gan Zang Bing Za Zhi 2005 (Reperfusion Injury) : Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of CD14 and NF-kappa B binding activity in Kupffer cells and inhibiting the productions of TNF alpha and IL-1
Rudolph et al., Genes Dev 2000 (Fetal Death) : NEMO/IKKgamma-deficient primary murine embryonic fibroblasts ( MEFs ) lack detectable NF-kappaB DNA binding activity in response to TNFalpha, IL-1 , LPS, and Poly ( IC ) and do not show stimulus dependent IkappaB kinase activity, which correlates with a lack of phosphorylation and degradation of IkappaBalpha
Raes et al., C R Seances Soc Biol Fil 1995 (Second Messenger Systems) : However several questions regarding the molecular mechanisms involved in particular steps of these cascades remain largely unresolved : how and at which subcellular level, do the cells produce these reactive oxygen intermediates that will contribute to NF kappa B activation in response to IL-1 or TNF-alpha ?
Cooke et al., Biochem J 2001 : The interleukin-1 (IL-1)-receptor associated kinase ( IRAK-1 ) is essential for IL-1 stimulated nuclear factor kappa B (NF-kappa B) activation
Ray et al., Agents Actions 1993 : Activation of the transcription factor NF kappa B by the proinflammatory cytokine interleukin-1 (IL-1) has been investigated in the human lung epithelial cell line ( A549 ) ... Activation of NF kappa B by IL-1 ( 1 pM ) was prevented when incubations were performed in the presence of the IL-1 receptor antagonist protein ( 1 nM ) ... The results suggest that a novel kinase pathway may be involved in the activation of NF kappa B by IL-1 in these cells
Croston et al., J Biol Chem 1995 : NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor associated protein kinase activity ... By receptor mutagenesis studies, we have identified a region of the cytoplasmic domain of IL-1RI that is required for both IL-1 mediated NF-kappa B activation and IL-1 dependent activation of a receptor associated protein kinase activity we term IRAK ... Therefore, we propose that IRAK activation is a necessary step in the activation of NF-kappa B by IL-1
Bonizzi et al., Eur J Biochem 1996 : In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha, while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105
Kothny-Wilkes et al., J Biol Chem 1998 : IL-1 significantly induced activation of the transcription factor NFkappaB in transformed keratinocytes ... Moreover, the proteasome inhibitor MG132, which inhibits IL-1 induced NFkappaB activation, completely prevented the protective effect of IL-1
Gautam et al., Blood 1995 : Furthermore, IL-1 alpha induces activation of transcription factor nuclear factor (NF)-kB , and sodium salicylate suppresses it in a dose dependent manner
Funakoshi et al., Int Immunopharmacol 2001 : We used two specific inhibitors, SB203580 which selectively inhibits p38 MAP kinase and LY294002 which inhibits PI3-kinase, respectively, to explore the involvement of these kinases in the IL-1 induced NF-kappa B activation, using a human glioblastoma cell line, T98G ... In this context, pretreatment of LY294002, but not SB203580, inhibited IL-1 induced NF-kappa B activation significantly ... These observations were prominent particularly in the TRAF6 transfection system, in which overexpression of wild type TRAF6 augmented the IL-1 mediated NF-kappa B and AP-1 activation, while dominant negative TRAF6 construct ( delta TRAF6 ) suppressed these activation ... Namely, LY294002 inhibited TRAF6 mediated IL-1 induced NF-kappa B and AP-1 activation markedly, while SB203580 inhibited TRAF6 induced AP-1 activation but not NF-kappa B activation ... Above results indicated that both PI3-kinase and p38 MAP kinase are differentially involved in IL-1 induced NF-kappa B and AP-1 activation
Jensen et al., J Immunol 2000 (Carcinoma, Hepatocellular) : The proinflammatory cytokine IL-1 induces the biosynthesis of a number of immunologically important proteins during infection, tissue damage, and/or stress, in part through the activation of the transcription factor NF-kappaB ... Overexpression of a membrane anchored fusion protein of sIL-1RAcP and MHC in HepG2 cells inhibits IL-1 mediated NF-kappaB activation, whereas coexpression of IL-1RI with membrane anchored sIL-1RAcP restores the capacity of the cells to respond to IL-1
Riis et al., Arch Dermatol Res 2004 : In unstimulated keratinocytes no NF-kappaB binding to the IL-8 kappaB binding sequence was detectable, whereas stimulation with IL-1alpha ( 10 ng/ml ) led to a significant ( P < 0.05 ) induction of NF-kappaB binding
Ali et al., Int J Biochem Cell Biol 2010 : IL-1 induced NF-kappaB DNA binding and activation by this transcription factor and this was attenuated by curcumin and apigenin
Sugioka et al., J Orthop Res 2010 : The transfection rate was assessed by counting FITC positive cells, and IL-1 induced NF-kappaB activation in the cells was assessed ... IL-1 induced NF-kappaB activation was significantly inhibited by pretreatment of the cells with NF-kappaB decoy combined with radial shock wave exposure
Bourke et al., J Immunol 1999 (Astrocytoma...) : However, dexamethasone failed to induce I kappa B or inhibit activation of NF-kappa B by IL-1 in the two cell types
Kim et al., Infect Immun 2004 (Enteritis...) : These cells do not signal through Toll-like receptor 4 (TLR4) or respond to bacterial lipopolysaccharide, but they express functional TLR5 and interleukin 1 (IL-1) receptors that signal the activation of NF-kappaB in response to bacterial flagellin or IL-1 stimulation
Song et al., Proc Natl Acad Sci U S A 2006 : Because IRAK1 is upstream of TRAF6 in IL-1 activation of NF-kappaB , the potential role of IRAK1 in LMP1 mediated NF-kappaB activation through TRAF6 and inhibitor of kappaB (IkappaB) kinase ( IKK ) was initially investigated
Bonizzi et al., Biochem Pharmacol 1999 : The PKC inhibitor calphostin C inhibited NF-kappaB activation by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta in Jurkat or NIH3T3 cells but not in MCF7 A/Z cells
Yu et al., J Biol Chem 2008 : Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1 mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression ... Consistently, TAK1 mutant with alanine substitution of these two residues severely inhibits IL-1 induced NFkappaB and AP-1 activities, whereas TAK1 mutant with replacement of these two sites with acidic residues slightly enhances IL-1 induced NFkappaB and AP-1 activities compared with the TAK1 wild-type
LaVallie et al., J Biol Chem 2006 (Osteoarthritis) : Chondrocyte cell based assays were used to evaluate the contribution of PKCzeta activity in NF-kappaB activation and extracellular matrix degradation mediated by IL-1 , TNF, or sphingomyelinase ... In primary chondrocytes, IL-1 and TNF-alpha caused an increase in NF-kappaB activity resulting in induction of aggrecanase-1 and aggrecanase-2 expression, with consequent increased proteoglycan degradation
Neves et al., Planta Med 2010 : Screening of five essential oils for identification of potential inhibitors of IL-1 induced Nf-kappaB activation and NO production in human chondrocytes : characterization of the inhibitory activity of alpha-pinene ... The ability of the alpha-pinene containing fraction to reduce IL-1 induced NF-kappaB activation and NO production warrants further studies to demonstrate the usefulness of alpha-pinene in the treatment of arthritic diseases and other conditions in which NF-kappaB and NO play pathological roles
Chan et al., J Rheumatol 2006 : The GLN and CS combination abrogated IL-1 induced gene expression of iNOS, COX-2, mPGEs1, and NF-kB at all timepoints
Yoshida et al., Neurotoxicology 2007 : DNA binding activities of NF-kappaB in these cells induced by interleukin (IL)-1 or LPS were inhibited by 1-BP
Birkenkamp et al., Leukemia 2004 (Acute Disease...) : The constitutive NF-kappaB activity could so far not be ascribed to the autocrine production of growth factors or to mutations in the Flt3 receptor, since anti-GM-CSF, -IL-1 , -IL6, -TNFalpha or the tyrosine kinase inhibitor AG1296 did not affect the NF-kappaB DNA binding activity
Itoh et al., Biol Pharm Bull 2007 (Arthritis, Rheumatoid) : These results suggest that DHT inhibits the TNFalpha induced IL-1alpha mRNA expression by inhibiting NF-kappaB activation, and contributes to the gender differences of the disease
Boyce et al., Bone 1999 : IL-1 and tumor necrosis factor in turn also regulate the expression of NF-kappaB
Brigelius-Flohé et al., Biochem J 1997 : To test the involvement of hydroperoxides we investigated whether IL-1 induced NF kappa B activation could be influenced by glutathione peroxidases ( GPx ) ... IL-1 induced NF kappa B activation was inhibited by selenium supplementation in control cells ... In ECVPHGPx+SelD+ under conditions of selenium restriction, IL-1 induced NF kappa B activation only to a similar extent as under conditions of selenium supplementation in controls, and activation was abolished with 50 nM sodium selenite ... These results show that overexpressed PHGPx is sufficient to inhibit NF kappa B activation, and suggests that NF kappa B activation by IL-1 is mediated by a preferential substrate of PHGPx, such as a fatty acid hydroperoxide, rather than by H2O2, the preferred substrate of the more abundant cytosolic GPx
Robinson et al., Immunity 1997 : IL-1alpha had no effect on proliferation, cytokine production, or NFkappaB activation in Th1 cells but activated NFkappaB and proliferation in Th2 cells
Stylianou et al., J Biol Chem 1992 (Thymoma...) : IL1 induction of NF-kappa B was rapid ( optimal at 15-30 min ) and transient in both cell types ... The IL1 receptor antagonist (IL1ra) , which binds strongly to the type I receptor, inhibited the NF-kappa B response in both cell lines ... The type I receptor mediates the induction of NF-kappa B in response to IL1 via a signaling mechanism that still remains to be identified
Fraczek et al., J Biol Chem 2008 : IRAK4 kinase-inactive mutant failed to mediate the IL-1R-TLR induced TAK1 dependent NFkappaB activation pathway, but mediated IL-1 induced TAK1 independent NFkappaB activation and retained the ability to activate substantial gene expression, indicating a structural role of IRAK4 in mediating this alternative NFkappaB activation pathway
Guo et al., Inflammation 2000 : As a result, antisense IRAK-2 ODN or antisense p110 PI 3-kinase ODN inhibited IL-1 induced NF-kappaB and AP-1 activation in HepG2 cells
Lindström et al., Mol Pharmacol 2008 : Short-term exposure to HDACi enhanced interleukin (IL)-1beta induced NF-kappaB activity as a result of potentiating IkappaB kinase (IKK)beta activity, thereby leading to persistent turnover of IkappaBalpha/epsilon proteins and prolonging NF-kappaB phosphorylation, nuclear localization, and DNA binding
Liu et al., Zhonghua Yan Ke Za Zhi 2002 : To evaluate the inductive role of interleukin (IL)-1 beta and the inhibitory role of pyrrolidine dithiocarbamate ( PDTC ) on the activation of nuclear factor (NF)-kappaB in the rat retina
Klingenberg et al., Eur J Immunol 2005 (Acute Disease) : IL-1alpha and TNF-alpha induced ICOSL in an NF-kappaB dependent manner on human umbilical vein endothelial cells ( HUVEC )
Wu et al., J Neurochem 2004 (Translocation, Genetic) : Consistently, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of inhibitory kappa B-alpha ( IkappaB-alpha ) was revealed by western blotting and immunofluorescence staining, which was blocked by helenalin, but not by U0126, SB202190, or SP600125
Burns et al., J Exp Med 2003 : In contrast, expression of MyD88 short (MyD88s), an alternatively spliced form of MyD88 that lacks only the short intermediate domain separating the DD and TIR domains, leads to a shutdown of IL-1/lipopolysaccharide induced NF-kappaB activation
Das et al., Mol Cell Biochem 1995 (Adenocarcinoma...) : Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B ... TNF alpha and IL-1 each can activate NF-kappa B and induce gene expression of manganese superoxide dismutase ( MnSOD ), a mitochondrial matrix enzyme which can provide critical protection against hyperoxic lung injury
You et al., J Exp Med 2001 : In contrast, IL-1/TNF stimulated nuclear factor (NF)-kappa B DNA binding activity and inhibitor of kappa B ( I kappa B ) phosphorylation was dramatically decreased in Shp-2 ( -/ ) - cells, while the expression and activity of NF-kappa B-inducing kinase (NIK), Akt, and I kappa B kinase (IKK) were not changed
Werman et al., Proc Natl Acad Sci U S A 2004 (Inflammation) : Under conditions of IL-1 receptor blockade, intracellular overexpression of the precursor and propiece forms of IL-1alpha were sufficient to activate NF-kappaB and AP-1
Sasu et al., Am J Physiol Heart Circ Physiol 2000 : Because the proliferative effect of IL-1 is additive with that of serum, the present studies assessed the role of IkappaB kinases ( IKKs ) and NF-kappaB in both IL-1- and serum induced VSMC proliferation ... Electrophoretic mobility shift assay and supershift analysis indicated that IL-1 induced NF-kappaB complexes consisted of p65/p50 heterodimers and p50 homodimers
Melisi et al., Mol Cancer Res 2009 (Neoplasm Metastasis...) : Our results showed that the secretion of IL-1alpha in MiaPaCa-2 cells constitutively activated NF-kappaB and increased the expression of NF-kappaB downstream genes involved in the different steps of the metastatic cascade, such as urokinase-type plasminogen activator, vascular endothelial growth factor, and IL-8
Homaidan et al., Mediators Inflamm 2003 (Enteritis) : IL-1 and ceramide, which have been shown to partially mediate IL-1 effects on IEC, activated NF-kappaB levels significantly
Ruiz-Deya et al., J Endourol 2002 (Inflammation...) : Stimulation of the human urothelial cells by hypoxia, known to activate NF-kappa B, resulted in an increase in the levels of IL-1 and IL-6 transcripts compared with hypoxia exposed cells in the presence of NF-kappa B inhibitors
Reddy et al., J Biol Chem 1997 : Furthermore, two PI 3-kinase-specific inhibitors, wortmannin and a dominant negative mutant of the p85 subunit, inhibited IL-1 induced activation of both NFkappaB and AP-1
Luo et al., Nephrol Dial Transplant 2009 : IL-1 induced the rapid activation of NF-kappaB in PTC ... NF-kappaB activation by IL-1 was transient, with a change from p65/p50 heterodimer to p50/p50 homodimer formation by 24 h and a switch to enhanced Smad signalling response to TGF beta
Born et al., J Biol Chem 1998 : In transient transfection assays, we were unable to demonstrate a role for AcPL in IL-1 induced activation of NFkappaB
Kuno et al., J Leukoc Biol 1994 : However, our recent study showed that the NF-kappa B activation is induced by IL-1/TNF in fibroblasts from patients with type A Niemann-Pick disease, with acid SMase deficiency ... This finding implies that acid SMase activity is not essential for the activation of NF-kappa B by IL-1/TNF at least in fibroblasts
Kwon et al., Endocrinology 1995 (Insulinoma...) : IL-1 induces a time dependent translocation of NFkappaB from cytosol to nucleus, with maximal translocation observed approximately 15-30 min after IL-1 treatment, as determined by electrophoretic mobility shift assays ... IL-1 induced translocation of NF kappa B was blocked by 100 microns 100 microM diethyldithiocarbamate or 100 microM pyrrolidine dithiocarbamate, further establishing a critical role for NF kappa B in the induction of iNOS by IL-1 in rat pancreatic beta-cells ... Activation of tyrosine kinase appears to precede NF kappa B activation, as the tyrosine kinase inhibitor genistein ( 100 microM ) blocks IL-1 induced translocation of NF kappa B
Loukinova et al., Int J Cancer 2001 (Carcinoma, Squamous Cell...) : In our study, we investigated the effect of the regulatory cytokines, IL-1alpha , EGF and TGF-beta1 on activation of NF-kappaB and Gro1 in primary and metastatic sublines of the murine SCC Pam 212
Carpentier et al., FEBS Lett 1999 : Interestingly, overexpression of TRAF1 in HEK293T completely prevented NF-kappaB activation induced by TNF, IL-1 , or overexpression of TRAF2 or TRAF6
Zhu et al., Biochem J 1998 : Cells on fibronectin showed a 1.5-2-fold enhancement in IL-1 induced NF-kappaB activity compared with levels in cells on poly ( l-lysine ) or bare tissue culture plates ... IL-1 induced NF-kappaB activity showed a successive, substratum independent increase during 4 h of attachment and spreading, whereas the inhibitory effect of fibronectin on the SAPK pathway was induced at the initial stages of attachment ... Thus fibronectin attachment causes an up-regulation of NF-kappaB activity in the presence of IL-1 , whereas in contrast it results in a pronounced decrease in IL-1 induced SAPK activity
Ishitani et al., EMBO J 2003 (Inflammation) : TAB2, a TAK1 binding protein, is involved in IL-1 induced NF-kappaB activation by physically linking TAK1 to TRAF6 ... However, IL-1 induced activation of NF-kappaB is not impaired in TAB2-deficient embryonic fibroblasts
Vakkila et al., Drug Discov Today 2005 : IFNgamma amplified IL-1 induced NF-kappaB responses
Novak et al., Nucleic Acids Res 1991 : Our results suggest that maximal transcriptional activation of the uPA gene by PMA, IL-1 and TNF alpha requires the induction of NFkB activity and the decay of a short lived repressor protein, possibly IkB
Pindolia et al., Hematopathol Mol Hematol 1996 : Furthermore, while unable to induce the activation of NF-kB alone, IL-4 enhanced the activation of NF-kB by IL-1
Sakoda et al., J Dent Res 2006 : Dominant negative Rac1 severely inhibited interleukin-1alpha induced NF-kappaB and AP-1 promoter activity
Li et al., Genes Dev 1999 (Skin Abnormalities) : NF-kappaB activation mediated by TNFalpha and IL-1 is diminished in IKK1-deficient mouse embryonic fibroblast (MEF) cells
Miyazaki et al., J Cell Biol 2000 : Interleukin 1alpha (IL-1alpha) strongly induced ERK activation as well as NF-kappaB activation
Marmiroli et al., FEBS Lett 1998 (Osteosarcoma) : The C-terminal portion of the type I IL-1 receptor ( IL-IRI ) is essential for IL-1 signalling and for IL-1 dependent activation of NF-kappaB
Song et al., Proc Natl Acad Sci U S A 1996 : A20 also inhibited TNF and IL-1 induced NF-kappaB activation, suggesting that it may inhibit NF-kappaB activation signaled by diverse stimuli
Tewes et al., Eur J Immunol 1997 (Thymoma...) : We therefore investigated whether the activation of the IL-1RI associated protein kinase could be a target for redox regulation and whether an altered activity of the kinase could influence IL-1 mediated NF-kappa B activation
Wald et al., Eur J Immunol 2001 : In this line which has low or no expression of the other known IRAK family members, we find that the IL-1 receptor associated kinase (IRAK) is essential for the activation of NFkappaB and JNK in response to IL-18
De Caterina et al., Arterioscler Thromb Vasc Biol 2001 : Electrophoretic mobility shift assays and immunoblotting of nuclear extracts showed that IFN-gamma activated signal transducers and activators of transcription ( STAT ) -1alpha and interferon regulatory factor (IRF)-1 but not NF-kappaB, whereas LC IL-1alpha activated NF-kappaB but not STAT-1alpha or IRF-1
Takehana et al., Biochem Biophys Res Commun 2002 : Despite having a strong inhibitory effect on the NF-kappaB dependent transcriptional activation, APC0576 does not inhibit the IL-1 induced DNA binding of NF-kappaB , degradation of I-kappaB-alpha, or phosphorylation of RelA ( p65 )
Oda et al., J Immunol 2002 : These results show that the inhibition of IL-1alpha mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha mediated activation of NF-kappaB ( p50/p65 ) or AP-1 ( c-Jun/c-Fos ) binding to the IL-8 promoter region
Weber et al., Am J Physiol Endocrinol Metab 2004 : In addition, these ligands impair IL-1 induced NF-kappaB and MAPK as well as IFN-gamma stimulated signal transducer and activator of transcription ( STAT ) 1 activation in beta-cells
Shattuck et al., Mol Cell Biol 1994 (Melanoma) : The effect of deletion or mutation of the MGSA/GRO alpha NF-kappa B element, combined with data from gel mobility shift analyses, indicates that the NF-kappa B p50/p65 heterodimer in RPE cells plays an important role in IL-1- and TNF alpha enhanced gene transcription ... In Hs294T cells, gel shift analyses indicate that IL-1 and TNF alpha induce NF-kappa B complex formation ; however, transactivation does not occur, suggesting that subtle differences in the NF-kappa B complexes may result in the inability of the cytokines IL-1 and TNF alpha to activate transcription of the MGSA/GRO genes
Hua et al., J Neuroimmunol 2002 : Electrophoretic mobility shift assay ( EMSA ) showed that IL-1 induced NF-kappaB and AP-1 DNA complex formation in astrocytes, and that SB203580 inhibited AP-1 complex formation
Granowitz et al., Mol Med 1995 (HIV Seropositivity...) : The effects of IL-1 and IL-1Ra on nuclear factor-kappa B (NF-kappa B) DNA binding activity, as measured by electrophoretic mobility shift assays, were also determined ... IL-1 increased NF-kappa B DNA binding activity and IL-1Ra blocked this effect ... IL-1 induces HIV-1 expression ( via the IL-1RI ) and NF-kappa B activity in U1 cells
McKean et al., Int Immunol 1995 : Gel shift analyses demonstrate that NF-kappa B nuclear translocation is stimulated primarily by IL-1 rather than by antigen receptor signals ... These results suggest that IL-1 induces both NF-kappa B nuclear translocation and the synthesis of a protein ( s ) responsible for terminating NF-kappa B-DNA interaction in the nucleus ... Antigen receptor signals prolong NF-kappa B-DNA interaction, probably by functionally antagonizing the IL-1 induced synthesis of a protein ( s ) responsible for the transient NF-kappa B-DNA interaction and consequently synergistically enhance IL-1 induced NF-kappa B-dependent gene transcription
Andoh et al., Pancreas 2000 (Pancreatic Neoplasms) : In PANC-1 cells, IL-1beta and TNF-alpha induced a rapid activation of nuclear factor (NF)-kappaB , and TGF-beta1 enhanced this activation slightly
Gabay et al., Blood 1999 (Liver Neoplasms) : Gel retardation assays showed that IL-4 induced the formation of a STAT6-DNA complex with a STAT6 binding element within the sIL-1Ra promoter, but had no effect on IL-1 induced NF-kappaB binding activity
Lin et al., J Biomed Sci 2004 : Furthermore, IL-1beta induced activation of nuclear factor-kappaB (NF-kappaB) was inversely correlated with the degradation of IkappaB-alpha in HTSMCs. IL-1beta induced COX-2 expression and PGE ( 2 ) synthesis were inhibited by the NF-kappaB inhibitor pyrrolidinedithiocarbamate
Matsumura et al., J Leukoc Biol 2004 : TLR2 promoter activity and nuclear factor (NF)-kappaB activation by IL-1alpha were inhibited by TGF-beta treatment ... Pretreatment with TGF-beta strongly suppressed IL-1alpha induced TLR2 promoter activity and NF-kappaB activation, which was consistent with the down-regulation of type I IL-1 receptor ( IL-1RI ) mRNA expression
Kalli et al., Mol Cell Biol 1998 : IL-1 alone stimulates an acute but transient NF-kappaB nuclear localization and a suboptimal NF-kappaB transcriptional response ... Together, these results suggest a mechanism by which signals from the T-cell antigen receptor and either CD28 or IL-1 synergistically regulate IL-2 gene transcription by modulating NF-kappaB nuclear translocation
Pousset et al., Eur Cytokine Netw 2000 : All these findings point to an interaction between Akt and NFkappaB dependent IL-1 signaling in the primary culture of astrocytes
Fredericks et al., Protein Eng Des Sel 2004 : The ease of producing antibodies in the scFv-Fc format permitted rapid identification of four lead clones ( C10, C13, C14, C15 ) that inhibit NF-kappaB nuclear translocation induced by IL-1
Lee et al., J Immunol 2002 : In WT cells, Vit D and IL-1 stimulated receptor activator of NF-kappaB ligand mRNA expression by 3- and 4-fold, respectively, and their combination produced a 7-fold increase
Huang et al., Proc Natl Acad Sci U S A 1997 : Overexpression of an IL-1RAcP mutant lacking its intracellular domain, the IRAK binding domain, prevented the recruitment of IRAK to the receptor complex and blocked IL-1 induced NF-kappaB activation
Thomassen et al., Cytokine 1999 : It failed to bind to the known IL-1-family members and, when co-expressed with the IL-1RI, had no effect on the binding of IL-1 and on subsequent nuclear factor kappaB (NFkappaB) activation
Liacini et al., Matrix Biol 2002 (Osteoarthritis, Hip) : These results suggest the involvement of MAPKs, AP-1 and NF-kappa B transcription factors in the IL-1 induction of MMPs in chondrocytes
Busik et al., Diabetes 2008 (Diabetic Retinopathy...) : Exposure of HRECs to 25 mmol/l glucose did not stimulate endogenous ROS production, activation of nuclear factor-kappaB (NF-kappaB) , extracellular signal related kinase ( ERK ), p38 and Jun NH ( 2 ) -terminal kinase ( JNK ), tyrosine phosphorylation, interleukin (IL)-1beta , or tumor necrosis factor-alpha (TNF-alpha) production and only slightly affected apoptotic cell death pathways compared with normal glucose ( 5 mmol/l )
Tago et al., Eur J Biochem 2001 : Presence of a genistein-responsive inhibitory mechanism on interleukin-1alpha induced NF-kappaB activation ... In the present study, we found that genistein, a tyrosine kinase inhibitor, augmented IL-1alpha dependent NF-kappaB activation, suggesting the presence of a tyrosine kinase mediating a suppression signal on NF-kappaB ... As determined by luciferase reporter gene assay using kappaB-responsive element, genistein enhanced IL-1alpha induced NF-kappaB activation
Anthonsen et al., J Biol Chem 2001 : Tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta are potent activators of the transcription factor NF-kappaB , induced during inflammatory conditions
Mendes et al., Mediators Inflamm 2001 : We also studied the ability of DPI to prevent IL-1 induced NF-kappaB activation and reactive oxygen species ( ROS ) production ... These results also support the involvement of reactive oxygen species in IL-1 induced NF-kappaB activation and expression of NF-kappaB dependent genes, such as iNOS
Sanjo et al., Mol Cell Biol 2003 (Fetal Death...) : Recently, serine/threonine kinase TAK1 and TAK1 binding protein 1 and 2 (TAB1/2) have been identified as molecules involved in IL-1 induced TRAF6 mediated activation of AP-1 and NF-kappa B via mitogen activated protein ( MAP ) kinases and I kappa B kinases, respectively ... However, the IL-1 induced activation of NF-kappa B and MAP kinases was not impaired in TAB2-deficient embryonic fibroblasts
Kutuk et al., Cytokine 2004 : Aspirin inhibits TNFalpha- and IL-1 induced NF-kappaB activation and sensitizes HeLa cells to apoptosis ... TNFalpha- and IL-1 induced NF-kappaB activation pathways mainly involve the phosphorylation and degradation of IkappaBalpha by a signalsome complex followed by nuclear translocation of NF-kappaB and target gene expression ... Our studies reveal that acetylsalicylic acid ( aspirin ) prevents TNFalpha- and IL-1 induced NF-kappaB activation in a dose dependent manner through inhibition of phosphorylation and degradation of IkappaBalpha and IkappaBbeta
Bi et al., Zhonghua Yi Xue Za Zhi 2008 (Diabetes Mellitus, Experimental...) : In the DM rats the IkappaBalpha protein expression in the skeletal muscle was significantly lower ( P < 0.05 ) and the NF-kappaB P65 DNA binding activity increased, and TNF-alpha, IL-1B , and IL-6 expression levels were up-regulated in comparison with the normal control group
Ding et al., J Biol Chem 1998 : A new quantitative cytometric technique, termed the ArrayScanTM, is described and used to measure NF-kappaB nuclear translocation induced by interleukin (IL)-1 and tumor necrosis factor-alpha (TNFalpha)
Renard et al., Antioxid Redox Signal 2001 : Using various antioxidants, including pyrrolidine dithiocarbamate and curcumin, we were unable to show a direct relationship between this IL-1 induced glutathione oxidation and NF-kappaB activation
Li et al., J Cell Sci 2005 : Overexpression of TRIP6 potentiates NF-kappaB activation by TNF, IL-1, TLR2 or Nod1, whereas a dominant negative mutant or RNA-interference construct of TRIP6 inhibits NF-kappaB activation by TNF, IL-1 , TLR2 or Nod1
Vig et al., J Biol Chem 1999 : However, it is currently unknown whether mPLK/IRAK catalytic activity is required for IL-1 dependent NF-kappaB activation
Gao et al., Biol Pharm Bull 2009 (Brain Ischemia...) : We also determined expression of TLR4 mRNA and MyD88 mRNA by in situ hybridization ( ISH ), activation of nuclear factor (NF)-kappaB by electrophoretic mobility-shift analysis ( EMSA ), and expression of interrleukin (IL)-1beta protein by Western blot
Wang et al., Toxicol Lett 2010 (Osteoarthritis, Knee) : In primary chondrocytes, modest concentrations of E2 reduced interleukin (IL)-1beta dependent NF-kappaB activation and MMP-1 expression
Kim et al., Exp Mol Med 2008 (Asthma...) : The stimulation of lymphoid cells with TNF-alpha, IL-1beta , and LPS resulted in significant ROS production and NF-kappaB activation
Chen et al., J Cell Biochem 2003 : Our results suggest that NF-kappaB activation in PIMs followed by phagocytizing lipopolysaccharide resulted in the up-regulation of TNF-alpha, IL-1beta , IL-6, IL-8, and COX-2, which could be alleviated by dexamethasone
Kanakaraj et al., J Exp Med 1999 (Cytomegalovirus Infections) : Interleukin (IL)-18 is functionally similar to IL-12 in mediating T helper cell type 1 ( Th1 ) response and natural killer ( NK ) cell activity but is related to IL-1 in protein structure and signaling, including recruitment of IL-1 receptor associated kinase (IRAK) to the receptor and activation of c-Jun NH2-terminal kinase (JNK) and nuclear factor (NF)-kappaB
Yang et al., Life Sci 2002 : Furthermore, IL-1beta induced NF-kappaB-specific DNA-protein complex formation in the nucleus was partially inhibited by sphondin ( 50 microM ) or PDTC ( 50 microM )