Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Iimuro et al., J Gastroenterol Hepatol 2007 : In Myd88 ( -/- ) mice after PH, induction of expression of immediate early genes involved in hepatocyte replication and phosphorylation of signal transducer and activators of transcription 3 ( STAT3 ) in the liver, and production of TNF-alpha/IL-6 by and activation of NF-kappaB in the Kupffer cells were grossly subnormal and were associated with impaired liver regeneration, while TLR2, 4 and 9, which recognize Gram negative and -positive bacterial products, are not essential for NF-kappaB activation and IL-6 production after PH
Zhang et al., Cell Biol Int 2006 : The present study has clearly demonstrated the ability of Hcy to elicit an inflammatory response in rat VSMCs by stimulation of IL-6 production and activation of NF-kappaB
Parikh et al., J Surg Res 1997 : In other reports, the nuclear factor-kappa B (NF-kappa B) regulated IL-6 production in certain cell types ... The inhibition of IL-6 production by the NF-kappa B inhibitors indicates that the IL-6 production is regulated by NF-kappa B , although further experiments are needed to test that hypothesis
Mitsiades et al., Oncogene 2002 (Multiple Myeloma) : In contrast, IL-6 does not cause sustained NF-kappaB activation, induces less pronounced Akt activation and FKHRL-1 phosphorylation than IGF-1, and increases the expression of only survivin
Takeda et al., Science 1999 (Limb Deformities, Congenital...) : In contrast, there was no impairment of NF-kappaB activation induced by either interleukin-1 or tumor necrosis factor-alpha in IKKalpha-deficient embryonic fibroblasts and thymocytes, indicating that IKKalpha is not essential for cytokine induced activation of NF-kappaB
Kogut et al., Innate Immun 2008 : Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2 dependent activation of AP-1 and NF-kappaB signaling pathways
Lee et al., Inflammation 2009 (Colitis) : The TNBS treatment caused colon shortening, increased myeloperoxidase activity, induced IL-1beta, TNF-alpha, and IL-6 expression in the colon, activated NF-kappaB , and potentiated the GAG degrading activities of intestinal microflora
Abbott et al., Mol Pharmacol 2000 : These findings suggest that NFAT is among the cofactors involved in NFkappaB dependent IL-6 gene induction by Ca ( 2+ ) -mobilizing receptors in vascular smooth muscle cells
Rafiee et al., Am J Physiol Gastrointest Liver Physiol 2009 : Together, these data demonstrate that 1 ) acid is a potent inducer of IL-6 and IL-8 production in HET-1A cells ; 2 ) MAPK and PKC signaling play a key regulatory role in acid mediated IL-6 and IL-8 expression via NF-kappaB activation ; and 3 ) the anti-inflammatory plant compound curcumin inhibits esophageal activation in response to acid
Gao et al., Cell Mol Life Sci 2009 : Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the activation of NF-kappaB by tumor necrosis factor ( TNFalpha ), interleukin-1beta (IL-1beta) and TLR ligands
Thirunavukkarasu et al., Hepatology 2006 (Disease Models, Animal...) : Inhibition of p38 and NF-kappaB activation by SB203580 and pyrrolidine dithiocarbamate, respectively, blocked endotoxin induced H ( 2 ) O ( 2 ), NO, TNF-alpha, and IL-6 synthesis ... In conclusion, endotoxin induced synthesis of NO, TNF-alpha, and IL-6 in HSCs is mediated by p38 and NF-kappaB , with involvement of H ( 2 ) O ( 2 ) in TNF-alpha production
Lewis et al., Mol Cell Biol 1994 : Mutational analysis of the -127/-118 NF-kappa B site indicates that both NF-kappa B and HMG-I(Y) binding at this site are essential for interleukin-1 induction of the promoter
Yang et al., J Mol Cell Cardiol 2007 (Disease Models, Animal...) : Thus, IL-6 mediated up-regulation of cardiac NF-kappaB , ICAM-1, CINC-1, -3, and MPO activity likely contributes to altered cardiac function following trauma-hemorrhage
Wang et al., Am J Surg 2010 (Blood Coagulation Disorders...) : Intra-abdominal sepsis led to significant decreases in colonic anastomotic bursting pressures, perianastomotic tissue HP contents, GSH levels, and plasma levels of PC, along with increases in perianastomotic tissue MPO activity, MDA levels, NF-kappaB activation , and plasma levels of TNF-alpha, IL-6 , and d-dimer
Sun et al., Acta Anaesthesiol Scand 2004 : Endotoxin caused transient production of TNF-alpha and IL-6 and activation of NF-kappaB in the intestine at peak times of 1, 4 and 1 h, respectively
Hellerbrand et al., Hepatology 1998 (Liver Cirrhosis, Experimental) : Cytokines induce NFkappaB activity in activated but not in quiescent HSCs with subsequent expression of NFkappaB-responsive genes, such as intercellular adhesion molecule (ICAM)-1 and interleukin (IL)-6
Ivanov et al., Cell Signal 2010 : The NF-kappaB dependent gene expression of IL8, IL6 , PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 ( PGE2 ) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB dependent gene expression in bystander cells
Kwon et al., Biochem Biophys Res Commun 2000 (Psoriasis) : To investigate the inducing mechanism of IL-6 by IGF-II, we examined the promoter activity of IL-6 and the DNA binding activity of NFkappaB , a strong regulator of IL-6 ... Therefore, these results suggest a novel role of IGF-II in psoriasis possibly by inducing IL-6 through the activation of NFkappaB mediated by downregulation of IkappaB
Wang et al., J Huazhong Univ Sci Technolog Med Sci 2005 (Shock, Septic) : 1 h, 2 h, 4 h and 6 h after LPS injection, the activation of NF-kappaB in blood mononuclear cells and the content of TNF-alpha and IL-6 in plasma was detected by enzyme linked immunoadsordent assay ( ELISA )
Quay et al., Am J Respir Cell Mol Biol 1998 : To investigate the role of NF-kappaB in the particulate induced IL-6 response, we exposed human airway epithelial cells ( BEAS-2B ) to ROFA in vitro
Alberti et al., Oncogene 2012 (Neoplasms, Glandular and Epithelial...) : In vitro analysis of EOC cell lines revealed that ligand stimulated EGFR activated NFkB dependent transcription and induced secretion of IL-6 and plasminogen activator inhibitor ( PAI-1 )
Greene et al., Biochim Biophys Acta 1999 : Interleukin-1 receptor associated kinase, IRAK, has been shown to activate NFkappaB in response to interleukin-1
Kurebayashi et al., J Steroid Biochem Mol Biol 1997 : These findings suggested that estrogens inhibit IL-6 production by interfering with the function of NF-kappaB rather than that of NF-IL6
Zhao et al., Am J Respir Cell Mol Biol 2009 : Exposure of HBEpCs to PM stimulated phosphorylation of NF-kappaB and C/EBPbeta, while the NF-kappaB inhibitor, Bay11-7082, or C/EBPbeta siRNA attenuated PM-induced COX-2 expression and IL-6 release
Schulze-Osthoff et al., EMBO J 1993 : This depletion of the mitochondrial oxidative metabolism resulted in resistance towards TNF cytotoxicity, as well as in inhibition of NF kappa B activation and interleukin-6 gene induction by TNF
Egan et al., J Biol Chem 1999 : Inhibition of interleukin-1 stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
Hideshima et al., Semin Oncol 2001 (Multiple Myeloma...) : PS-341 blocks the paracrine growth of human MM cells by decreasing their adherence to BMSCs and related NF-kappaB dependent induction of IL-6 secretion in BMSCs
Adams , Semin Oncol 2001 (Hematologic Neoplasms...) : Myeloma cells depend on NF-kappaB mediated transcription of cytokine growth factor interleukin-6 , angiogenesis through vascular endothelial growth factor, and the cell adhesion molecule VCAM-1 for adherence of the plasma cells to the stromal tissue in bone marrow
Creely et al., Am J Physiol Endocrinol Metab 2007 (Diabetes Mellitus, Type 2...) : NF-kappaB inhibitor reduced IL-6 in AbdSc adipocytes ( Control : 2.7+/-0.5 vs. NF-kappaB inhibitor : 2.1+/-0.4 ng/ml ; P < 0.001 )
Miyazawa et al., Am J Pathol 1998 (Arthritis, Rheumatoid...) : Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes : spontaneous activation of NF-kappaB and CBF1 ... Electrophoretic mobility shift assays revealed that the binding activity of p50 and p65 NF-kappaB subunits and CBF1 was significantly enhanced in the IL-6 high producing clones compared with that of IL-6 low producing clones and cultured sarcoma cells, suggesting that spontaneous activation of NF-kappaB and CBF1 may lead to the constitutive transcription of the IL-6 gene by rheumatoid FLSs
Son et al., J Cardiovasc Pharmacol 2008 : Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells
Holden et al., Br J Pharmacol 2007 : Using BEAS-2B bronchial epithelial cells, NF-kappaB dependent transcription and both release and mRNA expression of IL-6 and IL-8 were examined by reporter assay, ELISA and quantitative RT-PCR ... Similarly, H ( 3 ) and H ( 4 ) receptor agonists did not affect TNFalpha induced NF-kappaB dependent transcription, or IL-6 and IL-8 release at concentrations below 10 microM ... The anti-inflammatory glucocorticoid, dexamethasone, inhibited the histamine enhanced NF-kappaB dependent transcription and IL-6 and IL-8 release
Chauhan et al., Blood 1996 (Multiple Myeloma) : Multiple myeloma cell adhesion induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B
Muraoka et al., J Clin Invest 1996 : We further show that FK506 induces NF-kappaB regulated IL-6 production in vitro and in vivo, in particular in kidney
Jeong et al., Cytokine 2002 : Expression of TNF-alpha and IL-6 was regulated by a transcription factor, nuclear factor (NF)-kappaB
Shishodia et al., J Biol Chem 2004 (Inflammation...) : Guggulsterone suppressed DNA binding of NF-kappaB induced by tumor necrosis factor (TNF), phorbol ester, okadaic acid, cigarette smoke condensate, hydrogen peroxide, and interleukin-1
Cogswell et al., J Biol Chem 2003 : Stimulation of cells with inflammatory cytokines such as tumor necrosis factor alpha or interleukin-1 induces the degradation of I kappa B, the inhibitor of NF-kappa B , allowing nuclear accumulation of NF-kappa B and regulation of specific gene expression
Franchimont et al., J Clin Invest 1997 (Bone Resorption) : 5 ' deletions of the IL-6 promoter and targeted mutations of the multiple response element ( MRE ) /cAMP responsive element ( CRE ), the nuclear factor for IL-6 ( NF-IL-6 ), and the nuclear factor-kappaB (NF-kappaB) binding sites indicated that NF-IL-6 and NF-kappaB , in combination with MRE/CRE, binding sites are required for the induction of the IL-6 promoter by IL-6
Jewett et al., Cancer Immunol Immunother 2006 (Laryngeal Neoplasms...) : Moreover, NFkappaB mediated increase in IL-6 secretion by oral tumors may in part be responsible for the observed inactivation and death of the immune effectors
Li et al., J Exp Med 1999 : Accordingly, IKKbeta-deficient cells are defective in activation of IKK and NF-kappaB in response to either tumor necrosis factor alpha or interleukin 1
Wijagkanalan et al., Mol Pharmacol 2008 (Pneumonia) : DPML significantly inhibited tumor necrosis factor alpha, interleukin-1beta , and cytokine induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and inhibited NFkappaB and p38 mitogen activated protein kinase activation in the lung
Kim et al., J Immunol 2000 : We evaluated the role of NF-kappaB in HRV-16 induced IL-8 and IL-6 production by EMSA using oligonucleotides corresponding to the binding sites for NF-kappaB in the IL-6 and IL-8 gene promoters ... Thus, HRV-16 induces epithelial expression of IL-8 and IL-6 by an NF-kappaB independent pathway, whereas induction of GM-CSF is at least partially dependent upon NF-kappaB activation
Li et al., Biochem Biophys Res Commun 2009 (Herpes Genitalis) : More importantly, our data provide direct evidence that the activation of NF-kappaB is required for the production of both IL-6 and IFN-beta induced by HSV-2 in HCE cells
Vanden Berghe et al., Biochem Pharmacol 2000 : Furthermore, the enhanceosome displays histone acetylation activity, which turned out to be essential for IL-6 gene activation via NF-kappa B ... However, activation of NF-kappa B alone is not sufficient for IL-6 gene induction in response to TNF, as inhibition of the coactivated extracellular signal regulated kinase and p38 MAPK pathways blocks TNF mediated gene expression
Liu et al., Ann Clin Lab Sci 2001 (Cholestasis...) : NF-KB , in turn, initiates the transcription of cytokine genes ( eg, IL-6 , IL-8, TNF-alpha ), which triggers hepatic injury, at least in part, by a free radical mediated apoptotic mechanism
Brach et al., J Biol Chem 1993 : Analysis of deleted fragments of the IL-6 promoter indicated that transcriptional activation of the IL-6 promoter was due to enhanced binding activity of the transcription factor nuclear factor (NF)-kappa B
Kwon et al., Mol Cell Biol 2004 : Signaling molecule that interacts with mouse pelle-like kinase ( SIMPL ) is a signaling component required for tumor necrosis factor alpha (TNF-alpha) dependent but not interleukin-1 dependent NF-kappaB activation
Lentschat et al., J Immunol 2005 : Using the wasp venom derived peptide, mastoparan, to disrupt G protein coupled signaling, we identified a G protein dependent signaling pathway in HMEC stimulated with TLR4 agonists that is necessary for the activation of p38 phosphorylation and kinase activity, NF-kappaB and IL-6 transactivation , and IL-6 secretion
Ohishi et al., J Immunol 2005 (Bone Resorption) : In SOCS3-deficient BMMs, expression levels of TNF-receptor associated factor-6 and IkappaB were drastically reduced and receptor activator of the NF-kappaB ligand induced IkappaB phosphorylation was severely impaired in the presence of IL-6
Weiss et al., J Immunol 1997 : TNFR80 induces no cytotoxicity on its own, but is functional in these transfectants, as selective stimulation activates nuclear factor-kappaB (NF-kappaB) and induces NF-kappaB dependent cellular responses ( IL-6 and manganese superoxide dismutase )
Stewart et al., Proc Natl Acad Sci U S A 2004 (Nasopharyngeal Neoplasms) : The LMP2A mediated suppression of IL-6 was a consequence of NF-kappaB inhibition
Hara et al., Molecular vision 2009 : Hypoxia also attenuated both the LPS induced expression of IL-6 and IL-8, and the activation of NFkappaB in SV40-HCECs
Zhang et al., Curr Eye Res 2005 : Presence of the NF-kappaB inhibitor kamebakaurin in culture medium blocked P. aeruginosa induced NF-kappaB activation and inhibited IL-6 , IL-8, and TNF-alpha expression and secretion
Huang , Mediators Inflamm 2009 (MAP Kinase Signaling System) : Upregulation of Salmonella induced IL-6 production in Caco-2 cells by PJ-34, PARP-1 inhibitor : involvement of PI3K, p38 MAPK, ERK, JNK, and NF-kappaB
Kim et al., Mol Pharmacol 2008 (Inflammation...) : BOT-64 attenuates NF-kappaB regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL)-1beta , and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages ... BOT-64 attenuates NF-kappaB regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages
Rui et al., J Immunol 2007 : In this study, we demonstrate that PECAM-1 ligation with CD38-Fc fusion protein negatively regulates LPS induced proinflammatory cytokine TNF-alpha, IL-6 , and IFN-beta production by inhibiting JNK, NF-kappaB , and IFN regulatory factor 3 activation in macrophages
Qian et al., J Biol Chem 2001 : IRAK mediated translocation of TRAF6 and TAB2 in the interleukin-1 induced activation of NFkappa B
Tang et al., J Immunol 2007 : Leptin induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB , and p300 pathway in microglia ... Leptin mediated IL-6 production was attenuated by OBRl receptor antisense oligonucleotide, PI3K inhibitor ( Ly294002 and wortmannin ), Akt inhibitor ( 1L-6-hydroxymethyl-chiro-inositol-2- ( ( R ) -2-O-methyl-3-O-octadecylcarbonate ) ), NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), IkappaB protease inhibitor ( L-1-tosylamido-2-phenylenylethyl chloromethyl ketone ), IkappaBalpha phosphorylation inhibitor ( Bay 117082 ), or NF-kappaB inhibitor peptide
Brasier et al., Kidney Int 1994 (Acute-Phase Reaction) : NF-IL6 , a less potent transactivator, attenuates NF-kappa B mediated transcription late in the evolution of the acute-phase response
Manna et al., Clin Cancer Res 2007 (Inflammation...) : We showed by DNA binding assay that NF-kappaB activation induced by tumor necrosis factor (TNF), phorbol 12-myristate 13-acetate, lipopolysaccharide, ceramide, interleukin-1 , and H ( 2 ) O ( 2 ) was suppressed by morin ; the suppression was not cell type specific
Jennings-Gee et al., J Biol Chem 2006 : Because NF-kappaB plays a role in cytokine dependent induction of MnSOD, IL-6 , and FH, we assessed the effect of E1A on NF-kappaB in cells treated with TNF
Wang et al., Brain Res 2006 (Reperfusion Injury) : The purpose of this study is to investigate the role of nuclear factor kappa-B (NF-kappaB) in regulating IL-6 expression after ischemia
Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Li et al., Chin Med J (Engl) 2003 : mRNA expression of proinflammatory cytokines ( IL-1 beta, IL-6 , TNF-alpha, and MCP-1 ) and activation of NF-kappa B of HMC were measured using Reverse transcription-polymerase chain reaction ( RT-PCR ) and electrophoretic mobility shift assay ( EMSA ) respectively
Yamashiro et al., Biochem Biophys Res Commun 2010 : In addition to Ca2+ mobilization through the IP3-receptor, TRPV2 mediated intracellular Ca2+ mobilization is involved in NFkappaB dependent TNFalpha and IL-6 expression, while extracellular Ca2+ entry is involved in NFkappaB independent IL-6 production
Takeuchi et al., Antioxid Redox Signal 2000 : Thioredoxin inhibits tumor necrosis factor- or interleukin-1 induced NF-kappaB activation at a level upstream of NF-kappaB inducing kinase
Maeda et al., Biochem Biophys Res Commun 2007 (Colitis...) : LPS induced a small amount of HMGB1 in macrophages, but macrophages incubated with supernatant prepared from necrotic cells and containing large amounts of HMGB1 activated NF-kappaB and induced IL-6
Pinteaux et al., J Neurochem 2002 : Bacterial lipopolysaccharide (LPS) caused increased expression of IL-1RI, IL-1RII and IL-1RAcP mRNAs, induced the release of IL-1beta, IL-6 and prostaglandin-E2 ( PGE2 ), and activated nuclear factor kappaB (NF-kappaB) and the mitogen activated protein kinases ( MAPKs ) p38, and extracellular signal regulated protein kinase ( ERK1/2 ), but not c-Jun N-terminal kinase (JNK) in microglial cultures
Han et al., Circ Res 1999 : Pretreatment with a potent inhibitor of IkappaBalpha proteolysis, TPCK, completely blocked Sar1 Ang IIAng II-induced NF-kappaB activation and induction of endogenous IL-6 gene expression, which indicated the essential role of NF-kappaB in mediating IL-6 expression
Wang et al., Virus Res 2007 : Further experiments showed that IL-6 and TNF-alpha production were dependent on NF-kappaB , which was activated through I-kappaBalpha degradation
Farley et al., J Invest Dermatol 2006 (Dermatitis...) : In HaCaT cells and in reconstructed human epidermis ( RHE ), FasL triggered a NF-kappaB dependent mRNA accumulation of inflammatory cytokines ( tumor necrosis factor-alpha, IL-6 , and IL-1beta ), chemokines ( CCL2/MCP-1, CXCL1/GROalpha, CXCL3/GROgamma, and CXCL8/IL-8 ), and the adhesion molecule ICAM-1
Wang et al., J Immunol 2003 : IL-6 induces NF-kappa B activation in the intestinal epithelia ... Given the crucial role of IL-6 in the pathogenesis of chronic intestinal inflammation, it is not known whether IL-6 activates NF-kappaB , a central mediator of intestinal inflammation ... Basolateral IL-6 stimulation results in a maximal induction of NF-kappaB activation and NF-kappaB nuclear translocation at 2 h. IL-6 induces polarized expression of ICAM-1, an adhesion molecule shown to be important in the neutrophil-epithelial interactions in IBD ... Using various deletion constructs of ICAM-1 promoter, we show that ICAM-1 induction by IL-6 requires the activation of NF-kappaB ... We also demonstrate that overexpression of SOCS-3, a protein known to inhibit STAT activation in response to IL-6, down-regulates IL-6 induced NF-kappaB activation and ICAM-1 expression ... In summary, we demonstrate the activation of NF-kappaB by IL-6 in intestinal epithelia and the down-regulation of NF-kappaB induction by SOCS-3
Neff et al., Cell Microbiol 2001 (Arthritis, Rheumatoid...) : Our experiments also indicated that stimulation of FLSs with protein I/II induces nuclear translocation of NF-kappaB, AP-1 binding activity and that NF-kappaB plays a major role in IL-6 and IL-8 secretion from activated cells
Frey et al., Ann Rheum Dis 2013 (Arthritis, Psoriatic...) : Functionally, IL-36a induced the expression of IL-6 and IL-8 in FLS through p38/NFkB activation
Wullaert et al., J Biol Chem 2007 : Similar to the other ABINs, ABIN-3 binds to A20 and inhibits NF-kappaB activation induced by tumor necrosis factor, interleukin-1 , and 12-O-tetradecanoylphorbol-13-acetate
Ichiyama et al., Brain Res 2000 : Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB
Friedman et al., J Virol 2002 : We demonstrate here that the E3 region of Ad inhibits the activation of NF-kappa B induced by tumor necrosis factor alpha (TNF-alpha) and interleukin-1
Krasnow et al., Cytokine 1991 (Lymphoma, T-Cell) : Tumor necrosis factor-alpha, interleukin 1, and phorbol myristate acetate are independent activators of NF-kappa B which differentially activate T cells
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
de Wit et al., Leukemia 1998 (Inflammation) : In transient transfection assays we demonstrated that p100 has an inhibitory effect on the NF-kappaB dependent IL-6 promoter activity
Shin et al., Immunopharmacol Immunotoxicol 2009 (Inflammation) : MW inhibited secretion of TNF-alpha, IL-6 , and IL-8 possibly by inhibiting NF-kappaB activation
Sudo et al., Biochim Biophys Acta 2008 : In conclusion, The TNF-alpha and IL-6 signals from the blood are necessary for liver regeneration and NF-kappaB and STAT3 binding are activated via TNF-alpha and IL-6 signal pathways
Lin et al., J Am Soc Nephrol 2008 (Acute Kidney Injury...) : Measures of inflammation ( number of infiltrating neutrophils, myeloperoxidase activity, and induction of IL-6 and P-selectin ) and activation of NF-kappaB were lower in GC-G ( -/- ) mice compared with wild-type mice
Nakazato et al., Kidney Int 1998 : These results suggest that simultaneous activation of NF-kappa B and NF-IL6 is essential for IL-6 gene expression and that IL-1 and IL-4 cooperatively stimulate MC IL-6 production through their synergistic activation of NF-IL6
Guo et al., Free Radic Biol Med 2008 : CH3-Avn-c, a synthetically prepared methyl ester derivative of Avn-c with a high biological potency, significantly and dose dependently decreased mRNA expression and secretion of IL-6 , IL-8, and MCP-1 by HAEC as determined by real-time RT-PCR and ELISA, and it inhibited IL-1beta- and TNFalpha stimulated NF-kappaB activation as determined by a NF-kappaB DNA binding assay and a NF-kappaB luciferase reporter assay
Hauf et al., J Immunol 2003 (Inflammation) : As a consequence of NF-kappaB suppression, wild-type STEC induces significantly lower mRNA levels of IL-8, IL-6 , and IL-1alpha upon prolonged infection periods compared with bacteria lacking EspB
Cai et al., Exp Eye Res 2008 (Translocation, Genetic) : Induction of interleukin-6 in human retinal epithelial cells by an attenuated Herpes simplex virus vector requires viral replication and NFkappaB activation ... Inhibition of NF-kappaB translocation by an Adenovirus vector expressing a dominant negative IkappaB ( AdIkappaBam ) inhibited IL-6 up-regulation, indicating that NF-kappaB plays a role in increasing IL-6 expression in APRE-19 cells
Zhang et al., EMBO Rep 2005 : Using IKK(beta)-deficient bone-marrow derived macrophages and mouse embryo fibroblasts ( MEFs ), we show that IKK(beta) is essential for IKK and NF-(kappa)B activation as well as efficient IL-6 induction
de Rossi et al., Anesth Analg 2004 : LPS induced production of TNF-alpha and IL-6 as well as activation of NF-kappaB were significantly increased in the presence of xenon compared with controls
Ma et al., J Immunol 2010 : The NF-kappaB pathway inhibitor BAY-11, JNK inhibitor JNKi II, and p38 inhibitor SB203580 suppressed the synergistic effect of IL-6 and IL-17 on IL-6 expression
Chiang et al., Genetics and molecular biology 2009 : The results showed that, with a 36 % inhibition of NF-kB 1 expression, gene expression of both Toll-like receptor (TLR) 4 and interleukin (IL)-6 was consistently and significantly increased at both 1 h and 4 h following SE challenge, whereas the gene expression of MyD88 and IL-1ß was increased at 1 h and 4 h, respectively
Hierholzer et al., Arch Orthop Trauma Surg 2003 (Shock, Hemorrhagic) : Shock animals demonstrated increased mRNA levels of interleukin (IL)-6 and intercellular adhesion molecule (ICAM)-1 and increased activation of the transcription factors nuclear factor kappa B (NF-kappa B) and signal transducers and activators of transcription 3 ( Stat3 )
Viedt et al., Arterioscler Thromb Vasc Biol 2002 (Inflammation) : As demonstrated by cis element double stranded ( decoy ) oligodeoxynucleotides, NF-kappaB was involved in IL-6 release by MCP-1, whereas proliferation was dependent on AP-1
Sidell et al., Ann N Y Acad Sci 2002 (Endometriosis) : Our studies include a number of relevant findings : ( 1 ) RU486, acting as an antioxidant, can suppress activation of NFkappaB , a nuclear transcription factor that affects the expression of several inflammatory genes such as those for MCP-1, GM-CSF, CSF-1, and various adhesion molecules ; ( 2 ) IL-6 secretion from a variety of cell types including endometrial cells is inhibited by retinoic acid ; and ( 3 ) retinoids and PPARgamma ligands can upregulate the expression of scavenger receptors in cells of the monocyte/macrophage lineage
De Valck et al., Biochem Biophys Res Commun 1997 : However, A20 mutants that no longer associated with 14-3-3 proteins could still fully inhibit NF-kappaB activation induced by tumor necrosis factor, interleukin-1beta or phorbol 12-myristate 13-acetate, thus excluding a crucial role for 14-3-3 interaction in this A20 function
Xiao et al., Cancer Biol Ther 2004 (Multiple Myeloma) : NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple myeloma cells ... The mechanism of NF-kappaB activation of IL-6 appears to occur through the cooperation with c-Jun protein, that constitutively occupies the IL6-AP1 site, and this indicates a novel transcriptional mechanism for NF-kappaB in the activation of NF-kappaB-driven genes
An et al., Int Immunopharmacol 2002 : Catalposide, the major iridoid glycoside isolated from the stem bark of Catalpa ovata G. Don ( Bignoniaceae ), was found to inhibit the productions of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) , and the activation of nuclear factor kappaB (NF-kappaB) in RAW 264.7 macrophages activated with lipopolysaccharide (LPS)
Liu et al., Cytokine 2005 : Taken together, these results suggest that the disruption of NF-kappaB mediated transactivation plays a significant role in ER inhibition of IL-6 gene expression
Quiles-Perez et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : Furthermore, the results obtained in mice treated with DEN to induce hepatocarcinogenesis showed, after treatment with a PARP inhibitor ( DPQ ), a significant reduction both in preneoplastic foci and in the expression of preneoplastic markers and proinflammatory genes ( Gstm3, Vegf, Spp1 [ Opn ], IL6 , IL1b, and Tnf ), bromodeoxyuridine incorporation, and NF-kappaB activation in the initial steps of carcinogenesis ( P < 0.05 )
Moffatt et al., J Virol 1998 : Furthermore, using pentoxifylline, an inhibitor of NF-kappaB activation, we demonstrate that the NF-kappaB mediated IL-6 activation by NS1 is uncoupled from the apoptotic pathway
Chae et al., Immunopharmacol Immunotoxicol 2007 (Second Messenger Systems) : However, SB203580 had no effect on the IL-6 induced activation of NF-kappaB , and neither of the NF-kappaB inhibitors decreased the level of p38 MAPK activation in the IL-6 stimulated osteoblasts
Feng et al., Int Immunopharmacol 2010 (Disease Models, Animal...) : Meanwhile, HES could significantly reduce TNF-alpha, IL-6 , and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain
Nomi et al., Invest Ophthalmol Vis Sci 2010 : The zymosan induced release of IL-6 and IL-8 was attenuated by inhibitors of ERK, p38, JNK, and NF-kappaB signaling
Leung et al., Nephrol Dial Transplant 2008 : Furthermore, the increased synthesis of IL-6 and TNF-alpha by anionic pIgA in HMC was significantly diminished ( P < 0.01 ) in the presence of NF-kappaB inhibitor pyrrolidine dithiocarbamate and NF-kappaB blocking permeable peptides SN50 ( P < 0.01 )
Kim et al., J Cell Physiol 2009 (Calcium Signaling...) : Indeed, NECA induced increase of IL-6 protein expression and secretion was blocked by NF-kappaB inhibitors
Kim et al., Cytokine 2007 : Quercetin 3-O-beta- ( 2''-galloyl ) -glucopyranoside inhibits endotoxin LPS induced IL-6 expression and NF-kappa B activation in macrophages ... Taken together, QG-32 could inhibit NF-kappaB dependent IL-6 expression, targeting nuclear translocation of NF-kappaB complex downstream IkappaB degradation
Jeon et al., Biochem Mol Biol Int 1998 : Treatment of DEX to RAW 264.7 cells induced a dose related inhibition of NF-kappa B/Rel in chloramphenicol acetyltransferase activity, while NF-IL6 or Oct activation was not affected by DEX
Jensen et al., Environmental health : a global access science source 2003 : This suppression occurs at least at the level of IL-6 gene transcription and may be regulated by NF-kappaB
Takada et al., J Biol Chem 2004 : PTD-p65-P1 suppressed NF-kappaB activation induced by lipopolysaccharide, interleukin-1 , okadaic acid, phorbol 12-myristate 13-acetate, H ( 2 ) O ( 2 ), and cigarette smoke condensate as well as that induced by TNF
Baccam et al., Eur J Immunol 1999 : Thus, CD40 mediated IL-6 induction is independent of NF-kappaB activation and the binding of TRAF2 and -3, but CD40 must be engaged by trimeric CD154 on cell membranes to activate production of IL-6
Schwager et al., Vet Immunol Immunopathol 1998 (Ascorbic Acid Deficiency...) : The results suggest that ascorbate levels exert an early effect on immune homeostasis via reactive oxygen intermediates ( ROI ) -dependent expression of interleukin genes, since the transcription factor NF-kappa B is sensitive to ROI and regulates the expression of interleukin genes
Myskiw et al., J Virol 2009 : IL-6 induction is regulated by NF-kappaB , while IFN-beta induction is mediated by IFN-beta promoter stimulator 1 and IFN regulatory factor 3/NF-kappaB
Bradbury et al., Cancer Res 2001 : Recently, it also has been demonstrated that nonsteroidal anti-inflammatory agents inhibit tumor necrosis factor and interleukin-1 induced NF-kappaB activation and act as radiosensitizing agents
Lu et al., Mol Biol Cell 2005 (Helicobacter Infections) : Luciferase reporter gene assays and electrophoretic mobility shift assays showed that full IL-6 transcription required binding sites for nuclear factor-kappaB (NF-kappaB) , cAMP response element ( CRE ), CCAAT/enhancer binding protein (C/EBP), and activator protein (AP)-1
Nonomura et al., Hinyokika Kiyo 2008 (Neoplasms, Hormone-Dependent...) : Besides adrenal androgen blockade, dexamethasone suppresses the growth of prostate cancer via NFkappaB inactivation, and also via the inhibition of interleukin-6 production which is reportedly important for the growth of prostate cancer
Li et al., Molecular vision 2007 : Cultured limbal and conjunctival cells responded to stimulation by polyriboinosinic polyribocytidylic acid ( poly [ I:C ] ), palmitoyl-3-cysteine-serine-lysine-4 ( Pam3CSK ) and flagellin with increased secretion of IL-6 and IL-8 and the activation of NFkappaB
Gealy et al., J Gen Virol 2007 (Glioblastoma) : As the interleukin-6 (IL-6) promoter can be activated by both NF-kappaB and IE2p86, it was examined whether there is competition between these two factors
Aragane et al., J Invest Dermatol 1996 : NF-IL-6 binding to a 32P labeled NF-IL-6 binding sequence was enhanced 20 min after TGF-alpha stimulation and returned to basal levels within 90 min, whereas NFkappaB binding activity was enhanced after 20 min and returned to normal 60 min after stimulation
Piazza et al., Blood 2006 (Multiple Myeloma) : CK2 inhibition also resulted in impaired IL-6 dependent STAT3 activation and in decreased basal and TNF-alpha dependent I kappaB alpha degradation and NF-kappaB-driven transcription
Chiu et al., Mol Immunol 2008 : Thrombin induced IL-6 production in human synovial fibroblasts is mediated by PAR1, phospholipase C, protein kinase C alpha, c-Src, NF-kappa B and p300 pathway
Wu et al., Inflamm Res 2009 : Ang II upregulates the expression of TLR4 by RPMCs, resulting in enhanced NF-kappaB signaling and induction of CD40, TNF-alpha, and IL-6 expression
Faggioli et al., Eur J Biochem 1996 (Breast Neoplasms...) : Nuclear factor kappa B (NF-kappa B) , nuclear factor interleukin-6 ( NFIL-6 or C/EBP beta ) and nuclear factor interleukin-6 beta ( NFIL6-beta or C/EBP delta ) are not sufficient to activate the endogenous interleukin-6 gene in the human breast carcinoma cell line MCF-7
Ng et al., J Biol Chem 1994 : Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Jijon et al., Cell Signal 2004 : We report that although TNF induced NF-kappaB transcriptional activity is abolished in IKKgamma ( -/- ) cells, adenoviral gene delivery of NIK ( Ad5NIK ) still enhanced transcriptional activity and IL-6 mRNA accumulation
Yoshida et al., Life Sci 2006 : PEDF blocked the IL-6 induced STAT3 phosphorylations and NF-kappaB p65 activity in Hep3B cells
Scheinman et al., Mol Cell Biol 1995 : In HeLa cells, DEX activation of endogenous GR is sufficient to block tumor necrosis factor alpha or interleukin 1 activation of NF-kappa B at the levels of both DNA binding and transcriptional activation
Shah et al., Cell Physiol Biochem 2005 (Calcium Signaling) : The antidiabetic agent rosiglitazone upregulates SERCA2 and enhances TNF-alpha- and LPS induced NF-kappaB dependent transcription and TNF-alpha induced IL-6 secretion in ventricular myocytes ... Since NF-kappaB dependent pathways, including the upregulation of IL-6 secretion, were shown to protect neonatal rat ventricular myocytes from apoptosis upon TNFalpha stimulation, additional experiments were designed to determine whether rosiglitazone enhances TNFalpha induced NF-kappaB dependent transcription and IL-6 secretion ... Rosiglitazone had no significant effects on basal levels of NF-kappaB dependent transcription and IL-6 secretion
Blanchard et al., Dig Dis Sci 2001 (Adenocarcinoma...) : Previously, we have demonstrated that tumor necrosis factor-alpha (TNF-alpha) and gram negative bacterial lipopolysaccharide stimulate production of IL-6 and IL-8 and activation of the transcription factor NF-kappaB in the well differentiated pancreatic ductal adenocarcinoma cell lines CAPAN-1 and CAPAN-2
Fukano et al., Cytokine 2008 (Fever...) : Time lag between the increase of IL-6 with fever and NF-kappaB activation in the peripheral blood in inflammatory myofibroblastic tumor
Chae et al., Bone 2001 (MAP Kinase Signaling System) : Both the NF-kappaB inhibitors in the presence of SB203580 had a more inhibitory effect on IL-6 release
Lee et al., Virus Res 2007 (Lung Neoplasms) : IL-6 expression induced by DEN-2 infection was NF-kappaB dependent
Seki et al., Hepatology 2005 : In Myd88 ( -/- ) mice after PH, induction of expression of immediate early genes involved in hepatocyte replication and phosphorylation of STAT3 in the liver, and production of TNF-alpha/IL-6 by and activation of NF-kappaB in the Kupffer cells were grossly subnormal and were associated with impaired liver regeneration
Lin et al., J Immunol 2005 : The expression of IL-6 , IL-8, and MCP-1 was blocked by the preabsorption of anti-DV NS1 with DV NS1 or by the inhibition of NF-kappaB activation
Bowie et al., J Biol Chem 1997 : Here we have investigated the effect of a range of putative antioxidants on NF-kappaB activation by interleukin-1 and tumor necrosis factor as well as the ability of H2O2 to activate NF-kappaB in primary human umbilical vein endothelial cells and the transformed human endothelial cell line ECV304
Ammit et al., Am J Respir Cell Mol Biol 2002 : beta-Agonists augmented TNF-alpha induced IL-6 secretion, reflecting an additive effect of NF-kappaB and CRE response elements on IL-6 gene expression
Takeshita et al., J Immunol 1996 : These results suggest that IL-4 may inhibit the transcription of the IL-6 gene by affecting NF-kappaB binding activity, while IL-10 may inhibit the IL-6 mRNA levels post-transcriptionally, without suppressing promoter activity
Lee et al., Biochim Biophys Acta 2007 : HB-EGF induces delayed STAT3 activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell ... Furthermore, these HB-EGF mediated up-regulation of IL-6 mRNA expression and secretion were inhibited by NF-kappaB inhibitor Bay117082 ( 2.5 microM ) treatment suggesting involvement of NF-kappaB pathway
Sun et al., Nature 2000 : Activation of NF-kappaB by tumour-necrosis factor alpha and interleukin-1 was unaffected in the mutant mice
Gri et al., J Biol Chem 1998 (Cell Transformation, Viral) : Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus transformed B cells and macrophages
Heyen et al., Brain Res Mol Brain Res 2000 : Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB ... The purpose of this study was to determine if interleukin (IL)-10 inhibits lipopolysaccharide (LPS) induced IL-6 production in microglia by inhibiting activation of nuclear factor-kappaB (NF-kappaB) ... Because NF-kappaB is the predominant transcription factor responsible for IL-6 transcription in response to inflammatory stimuli, it was hypothesized that IL-10 inhibited IL-6 production by preventing nuclear translocation of NF-kappaB ... Furthermore, inhibition of NF-kappaB activity with tosyl-Phe-chloromethlyketone ( a serine protease inhibitor that prevents degradation of the NF-kappaB-IkappaB complex ), completely blocked LPS induced IL-6 production ... These data suggest that IL-10 inhibited IL-6 production in microglia by decreasing the activity of NF-kappaB and, therefore, extend what little is known of the intricate relationship between anti-inflammatory and inflammatory cytokines in the central nervous system
Ahn et al., J Biol Chem 2007 : Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta , and epidermal growth factor
Totlandsdal et al., Toxicol In Vitro 2010 : The findings suggest that ultrafine carbon black induced release of IL-6 strongly depends on IL-1 and that activation of MAPKs and NF-kappaB is involved in this response
Franchi et al., Nat Immunol 2006 (Salmonella Infections) : Here we demonstrate that salmonella strains either lacking flagellin or expressing mutant flagellin were deficient in activation of caspase-1 and in interleukin 1beta secretion, although transcription factor NF-kappaB dependent production of interleukin 6 or the chemokine MCP-1 was unimpaired
Lieb et al., J Neurochem 1998 (Astrocytoma) : Promoter deletion analysis revealed that IL-1beta induced IL-6 expression required the transcription factor nuclear factor-kappaB (NF-kappaB) , whereas SP- and histamine induced IL-6 synthesis was essentially controlled by NF-IL-6
Merentie et al., Amino Acids 2007 (Acute Disease...) : Glutathione level and catalase activity changed transiently, and the effect of Me(2)Spm was clear at 24 h. Serum inflammatory cytokine levels increased already at 4 h whereas NF-kappaB was distinctly activated only at 24 h. Me(2)Spm prevented the increase in TNF-alpha and IL-6 while it had no effect on NF-kappaB activation
Chae et al., Immunopharmacol Immunotoxicol 2005 : Both the NF-kappaB inhibitors in the presence of SB203580 had more inhibitory effect on IL-6 release
Li et al., Molecular vision 2007 : Inhibition of NF-kappaB partially prevented the induction of IL-1alpha, IL-8, and ELAM-1, but not IL-6
Filer et al., Arthritis Rheum 2009 (Arthritis, Rheumatoid) : NF-kappaB activation was required for production of both IL-6 and CCL5
Belt et al., Am J Obstet Gynecol 1999 : In this study we investigated the possible role of the nuclear transcription factor NF-kappaB in interleukin-1 signaling, leading to the expression of cyclooxygenase 2 and prostaglandin production in human myometrial cell cultures ... Stimulation of human myometrial cells with interleukin 1 leads to rapid activation of the transcription factor NF-kappaB , which is functionally linked to the expression of cyclooxygenase 2 messenger ribonucleic acid, protein, and prostaglandin synthesis
Kim et al., J Immunol 2008 (Bacterial Infections...) : Consistently, Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of TNF-alpha and IL-6 as well as increased NF-kappaB and MAPK activation in response to the dipeptide KF1B, the Nod1 agonist
Feng et al., Mol Cell Biol 2005 : The LIM protein Ajuba influences interleukin-1 induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex
Mahon et al., J Biol Chem 1995 (Lymphoma, T-Cell...) : The tyrosine kinase inhibitor herbimycin A was found to block NF-kappa B stimulation in response to interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells
Komine et al., Mol Immunol 2007 (Periodontitis) : Con A low-affinity saliva Lf peptides, PR3 treated Lf preparation and two of four synthetic polypeptides induced the production of interleukin IL-6, monocyte chemoattractant protein-1 and IL-8, and the activation of NF-kappaB in human oral epithelial HSC-2 cells
Georganas et al., J Immunol 2000 (Arthritis, Rheumatoid) : Inhibition of NF-kappaB activation significantly reduced the spontaneous and IL-1beta induced secretion of IL-6 and IL-8 by RA FLS and the IL-1ss induced production of IL-6 and IL-8 by human dermal fibroblasts ... NF-kappaB was essential for IL-6 expression, because fibroblasts in which both NF-kappaB p50/p65 genes were deleted failed to express IL-6 in response to IL-1
Vanden Berghe et al., J Biol Chem 1998 : In the mouse fibrosarcoma cell line L929, the nuclear factor (NF)-kappaB plays a crucial role in IL-6 gene expression mediated by tumor necrosis factor (TNF)
Donnelly et al., J Immunol 1993 : Because NF-kappa B activation is required for transcription of many cytokine genes, including IL-6 , the ability of IL-4 to suppress NF-kappa B activity in monocytes suggests a potential mechanism by which this molecule may inhibit the expression of multiple cytokines
Iliopoulos et al., Cell 2009 (Inflammation) : IL6 mediated activation of the STAT3 transcription factor is necessary for transformation, and IL6 activates NF-kappaB , thereby completing a positive feedback loop
Legrand-Poels et al., Biochem J 2000 (Adenocarcinoma...) : Thus IL-6 promoter repression in HTM-29 cells probably results from a failure of cytokine activated NF-kappaB to exert its transactivating activities
Raychaudhuri et al., Clin Immunol 2002 (Hypertension, Pulmonary) : However, mRNA expression was decreased compared to controls for NF-kappaB regulated genes, granulocyte macrophage colony stimulating factor, interleukin-6 , macrophage inflammatory protein-1alpha ( MIP-1alpha ), and vascular endothelial growth factor ... However, mRNA expression was decreased compared to controls for NF-kappaB regulated genes, granulocyte macrophage colony stimulating factor, interleukin-6 , macrophage inflammatory protein-1alpha ( MIP-1alpha ), and vascular endothelial growth factor
Munitz et al., Gastroenterology 2010 (Colitis...) : In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6, interleukin-1beta , and tumor necrosis factor alpha ) and activation of MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation ... In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , interleukin-1beta, and tumor necrosis factor alpha ) and activation of MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation
Lee et al., American journal of physiology. Renal physiology 2007 : In addition, IL-6 increased the level of nuclear factor-kappaB (NF-kappaB) phosphorylation
Pruett et al., J Immunotoxicol 2006 : The suppression of IL-6 production and inhibition of NF-kappa B activation was greater than additive when comparing animals given both compounds to those given either compound separately
Vega-Ostertag et al., Arthritis Rheum 2005 : Our data show that aPL induces significant increases in TF transcription, function, and expression, in IL-6 and IL-8 up-regulation, and in iNOS expression on HUVECs and that these processes involve phosphorylation of p38 MAPK and activation of NF-kappaB
de Wit et al., Exp Hematol 1996 : The effects of IFN-gamma on the transcription factors were specific, since no change was observed in the expression of NF-IL-6 or I kappa B alpha, the inhibitor of NF-kappa B
Sheller et al., Exp Lung Res 2009 (Asthma...) : Accompanying the exaggerated inflammation was an increase in the cytokines granulocyte colony stimulating factor ( G-CSF ), interleukin (IL)-15, and KC. Interestingly, the counter regulatory interleukin , IL-10, was suppressed by NF-kappa B activation
Jeon et al., Toxicol Lett 1999 : Treatment of AAF to RAW 264.7 cells induced a dose related inhibition of NF-kappa B/Rel in chloramphenicol acetyltransferase activity, while either AP-1 or NF-IL6 activation was not affected by AAF
Wang et al., Nat Immunol 2006 : Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1, transcriptional activators of innate immunity
Viji et al., Int Immunopharmacol 2010 : These results suggest that betulinic acid inhibited IL-6 production by preventing p65 NF-kappaB nuclear translocation and there is a possibility that this prevention of p65 nuclear translocation may involve p38 and ERK MAPKs as cross talks occur between MAPK and NF-kappaB pathways
Mann et al., J Biol Chem 2002 : CD40 induces interleukin-6 gene transcription in dendritic cells : regulation by TRAF2, AP-1, NF-kappa B , AND CBF1
Fiebich et al., J Immunol 2000 (Astrocytoma...) : However, activation of NF-kappaB was not involved in SP-induced expression of IL-6
Cui et al., Circ Res 2006 : In vascular smooth muscle cells ( VSMCs ), Ang II signaling activates interleukin (IL)-6 expression, a cytokine producing acute-phase inflammation, mediated by the transcription factor nuclear factor kappaB (NF-kappaB)
Khalaf et al., BMC immunology 2010 (Inflammation) : The present study shows that NF-kappaB regulated IL-6 but not CXCL8
Hehlgans et al., Eur Cytokine Netw 2003 (Fibrosarcoma) : Activation of the lymphotoxin-beta receptor induces NFkappaB dependent interleukin-6 and MIP-2 secretion in mouse fibrosarcoma cells ... MIP-2 and IL-6 secretion was NFkappaB dependent because IkappaB transfected cells released significantly reduced amounts of both mediators
Tanabe et al., Journal of neuroinflammation 2010 (Glioma) : These results strongly suggest that TNF-alpha induces IL-6 synthesis through the JAK/STAT3 pathway in addition to p38 MAP kinase and SAPK/JNK in C6 glioma cells, and that phosphorylation of NFkappaB at Ser 536 and Ser 468, and NADPH oxidase are involved in TNF-alpha stimulated IL-6 synthesis
Muraoka et al., Transplantation 1997 (Anoxia...) : Hypoxia, but not reoxygenation, induces interleukin 6 gene expression through NF-kappa B activation ... We have previously shown that NF-kappa B plays an essential and indispensable role in the transcriptional activation of the IL-6 gene induced by various stimuli, including IL-1 and tumor necrosis factor-alpha ... This hypoxia induced NF-kappa B activation resulted in the kappa B-dependent transcriptional activation of the IL-6 gene
Kim et al., J Ethnopharmacol 2005 : Cheongyeolsaseuptang inhibits production of TNF-alpha, IL-6 and IL-8 as well as NF-kappa B activation in human mast cells
Dey et al., Cell Death Differ 2008 : We show in this study that R-Roscovitine can downregulate nuclear factor-kappa B (NF-kappaB) activation in response to tumor necrosis factor (TNF)alpha and interleukin 1
Kempuraj et al., Int Arch Allergy Immunol 2003 : Azelastine inhibits secretion of IL-6 , TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells ... Azelastine inhibited hCBMC secretion of IL-6 , TNF-alpha and IL-8, possibly by inhibiting intracellular Ca2+ ions and NF-kappaB activation
Jeon et al., Immunopharmacology 2000 : Treatment of DEX to RAW 264.7 cells induced a dose related inhibition of NF-kappaB/Rel and AP-1 in chloramphenicol acetyltransferase activity, while neither NF-IL6 nor CREB/ATF activation was affected by DEX
Shibanuma et al., FEBS Lett 1994 : Inhibition by N-acetyl-L-cysteine of interleukin-6 mRNA induction and activation of NF kappa B by tumor necrosis factor alpha in a mouse fibroblastic cell line, Balb/3T3
Iber et al., Arch Biochem Biophys 2000 : Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-kappaB binding at the transcription start site
Maliner-Stratton et al., Neoplasia (New York, N.Y.) 2001 (Adenocarcinoma...) : Interleukin-1beta induced promatrilysin expression is mediated by NFkappaB regulated synthesis of interleukin-6 in the prostate carcinoma cell line, LNCaP ... We now demonstrate that IL-1beta induced promatrilysin expression is mediated by an indirect mechanism that requires nuclear factor Kappa B (NFkappaB) dependent synthesis of IL-6 ... Inhibition of IL-6 activity attenuated IL-1beta induced promatrilysin, but not NFkappaB transactivation activity indicating that IL-6 acts downstream of NFkappaB in potentiation of IL-1beta mediated promatrilysin expression ... These data provide evidence that NFkappaB mediated IL-6 synthesis is required for IL-1beta induced promatrilysin expression, and IL-6 signaling through STAT3 plays a role in IL-1beta induced promatrilysin expression
Zhou et al., Zhonghua Wai Ke Za Zhi 2004 (Adenocarcinoma...) : IND may inhibit the activation of NF-kappaB , decrease serum TNF-alpha and IL-6 levels and thus alleviate the cachexia
Mazighi et al., Am J Physiol Heart Circ Physiol 2004 (Hyperplasia...) : In LPS stimulated rat SMCs, 1 ng/ml recombinant murine IL-10 ( mIL-10 ) reduced I-kappaBalpha and I-kappaBbeta degradation, NF-kappaB activation, as well as the expression of the NF-kappaB dependent gene IL-6 by 32 %, 31 %, 75 %, and 19 %, respectively ( P < 0.05 for all )
Zerbini et al., Cancer Res 2003 (Neoplasms, Hormone-Dependent...) : Deregulated activation of the IL-6 promoter is for the most part mediated by a combined constitutive activation of the nuclear factor (NF)-kappaB p50 and p65 and the activator protein 1 (AP-1) JunD and Fra-1 family members as demonstrated by electrophoretic mobility shift assays, site directed mutagenesis, and transfection experiments
Purkerson et al., Eur J Immunol 2005 : The TRAF6, but not the TRAF2/3, binding domain was found to regulate IL-8 and IL-6 production, and induce activation of NF-kappaB and Jun kinase in lung fibroblasts, demonstrating for the first time that CD40ct domains can function independently to regulate pro-inflammatory responses of primary human fibroblasts
Heyninck et al., J Cell Biol 1999 : We show that A20 does not inhibit TNF- induced nuclear translocation and DNA binding of NF-kappaB, although it completely prevents the TNF- induced activation of an NF-kappaB dependent reporter gene, as well as TNF induced IL-6 and granulocyte macrophage-colony stimulating factor gene expression
Hohmann et al., J Biol Chem 1992 (Leukemia, Promyelocytic, Acute) : NF-kappa B activation by phorbol 12-myristate 13-acetate ( PMA ) and interleukin-1 was inhibited by staurosporin
Keller et al., J Biol Chem 1996 (Prostatic Neoplasms) : Finally, we confirmed that IkappaBalpha inhibits NFkappaB mediated activation of the interleukin-6 promoter
Tsai et al., PloS one 2013 : This increased secretion of TNF-alpha and IL-6 and activation of NF-kB , ERK, and JNK was significantly inhibited by the addition of either mannan or mannose
Matsui et al., Cardiovasc Res 1999 (Anoxia) : Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes
Chung et al., J Biol Chem 2005 (Insulin Resistance) : Collectively, these data demonstrate for the first time that trans-10, cis-12 CLA promotes NFkappaB activation and subsequent induction of IL-6 , which are at least in part responsible for trans-10, cis-12 CLA mediated suppression of peroxisome proliferator activated receptor gamma target gene expression and insulin sensitivity in mature human adipocytes
Kahlon et al., Bioorg Med Chem 2009 : The structure-activity relationship of various substituents on an imidazoline core structure was evaluated for the ability to inhibit NF-kappaB mediated IL-6 production ... Several derivatives were found to inhibit NF-kappaB mediated IL-6 production in the nanomolar range in IL-1beta stimulated human blood
Wright et al., Am J Physiol Heart Circ Physiol 2002 : However, interleukin-1beta and phorbol 12-myristate 13-acetate also activated NF-kappaB but did not evoke TNF-alpha expression, revealing that this factor is not sufficient for cytokine production
Walker et al., Stem Cells Dev 2010 : Direct intrathecal implantation of mesenchymal stromal cells leads to enhanced neuroprotection via an NFkappaB mediated increase in interleukin-6 production
Kato et al., Mol Immunol 2002 : The IL-6 production by human fibroblasts in response to these cystatins was inhibited by tyrosine kinase inhibitors and an inhibitor of NF-kappa B activation ... These findings supply evidence that cystatins SA1 and SA2 adhere to human fibroblasts and that the event results in tyrosine phosphorylation and upregulation of the release of IL-6 mediated enhancement of NF-kappa B activity
Bhaumik et al., Oncogene 2008 (Breast Neoplasms...) : Impaired NF-kappaB activity was evident from reduced phosphorylation of the NF-kappaB inhibitor IkappaBalpha, reduced NF-kappaB DNA binding activity and suppressed expression of the NF-kappaB target genes IL-8, IL-6 and matrix metalloproteinase-9
Li et al., Exp Dermatol 2009 (Candidiasis, Cutaneous) : Anti-TLR2 neutralizing antibody, NFkappaB and p38MAPK inhibitors blocked the PLM induced secretion of IL-6 , IL-8 in keratinocytes, but no such effect was observed in pretreatment with anti-TLR4 neutralizing antibody and lipopolysaccharide inhibitor ( polymyxin B )
Tipton et al., J Periodontol 2007 (Periodontitis) : PGE ( 2 ) and the transcription factor nuclear factor-kappa B (NF-kappaB) regulate IL-1beta stimulated IL-6 production
Fenton et al., Int J Cancer 2008 (Disease Models, Animal...) : These data indicate that adiponectin acts on preneoplastic colon epithelial cells to regulate cell growth via 2 distinct pathways inhibiting leptin induced NF-kappaB dependent autocrine IL-6 production and trans-IL-6 signaling
Birkenkamp et al., Leukemia 2004 (Acute Disease...) : The constitutive NF-kappaB activity could so far not be ascribed to the autocrine production of growth factors or to mutations in the Flt3 receptor, since anti-GM-CSF, -IL-1, -IL6 , -TNFalpha or the tyrosine kinase inhibitor AG1296 did not affect the NF-kappaB DNA binding activity
Chaturvedi et al., J Biol Chem 1997 : As sanguinarine also inhibited NF-kappaB activation induced by interleukin-1 , phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers
Scholz et al., Int J Mol Med 2004 (Cytomegalovirus Infections) : Thrombin/PAR-1 mediated signaling stimulated PKC and NF-kappaB dependent IL-6 and IL-8 gene expression via phosphoinositide 3-kinase and further downstream via p42/44 and p38 MAPKs
Giri et al., J Biol Chem 1998 (Lymphoma, T-Cell...) : HuT-78 cells were also resistant to NF-kappaB activation induced by phorbol ester, H2O2, ceramide, endotoxin, and interleukin-1
El-Hage et al., PloS one 2008 : Pretreatment with the NF-kappaB inhibitor parthenolide provided evidence that Tat+/-morphine induced release of MCP-1, IL-6 and TNF-alpha by astrocytes is NF-kappaB dependent
Viedt et al., J Am Soc Nephrol 2002 (Nephritis) : In the present experiments, NF-kappaB and AP-1 were involved in the MCP-1 mediated induction of IL-6 , as demonstrated by cis element double stranded ( decoy ) oligonucleotides ( ODN )
Dasu et al., Diabetes 2008 : High glucose increased TLR expression, myeloid differentiation factor 88, interleukin-1 receptor associated kinase-1, and nuclear factor-kappaB (NF-kappaB) p65 dependent activation in THP-1 cells
Escotte et al., Eur Respir J 2003 (Cystic Fibrosis) : To determine whether FP reduces cytokine production in bronchial epithelial cells via NF-kappaB, the authors investigated the nonstimulated and the Pseudomonas aeruginosa lipopolysaccharide (LPS) stimulated production of NF-kappaB dependent interleukin (IL)-6 , IL-8 and RANTES ( regulated on activation, T-cell expressed and secreted ) along with the activation of NF-kappaB in non-CF and CF human bronchial gland epithelial cells
Jones et al., J Infect Dis 2006 (Escherichia coli Infections...) : Neutrophil recruitment requires nuclear factor (NF)- kappa B, but IL-6 was neither sufficient nor essential to induce NF- kappa B-mediated gene expression in the lungs
Jiang et al., J Biol Chem 2004 : Without ERK activation, interleukin-1beta induces only acute and transient NF-kappaB activation
Anderson , Cancer J 2001 (Multiple Myeloma...) : The upregulation of NF-kappaB dependent interleukin-6 (IL-6) transcription and secretion that occurs following adhesion of myeloma cells to bone marrow stromal cells ( BMSCs ) may serve as a potential therapeutic target, as IL-6 is a growth and survival factor for myeloma cells ... Accordingly, proteasome inhibitors inhibit activation of NF-kappaB and induce apoptosis of myeloma cells ; they also inhibit the NF-kappaB dependent up-regulation of IL-6 in BMSCs and related paracrine growth of adherent tumor cells
Ono et al., Shock 2004 (Hepatitis, Alcoholic...) : We previously demonstrated that production of interleukin-6 (IL-6) and granulocyte colony stimulating factor ( G-CSF ), mediated by nuclear factor-kappa B (NF-kappa B) , each make essential contributions to organ injury and inflammation in a rodent model of controlled HS, and we proposed in this study to examine the hypothesis that the increased susceptibility to MOF after shock/trauma in the setting of chronic ethanol use is due to an exaggerated activation of NF-kappa B and production of these proinflammatory cytokines
Zhang et al., Proc Natl Acad Sci U S A 1994 : Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B
Ye et al., J Neuroimmunol 2001 : The purpose of this study was to determine if binding of nuclear factor kappaB (NFkappaB) to the IL-6 promoter is responsible for the age related increase in brain IL-6
Reyna et al., Diabetes 2008 (Diabetes Mellitus, Type 2...) : Palmitate also increased IL-6 and SOD2 gene expression, and this effect was prevented by inhibiting NFkappaB
McCarty , Med Hypotheses 1999 (Alzheimer Disease) : NO has an autocrine anti-inflammatory impact on endothelium, owing in part to antagonism of NF-kappaB activity ; since induction of IL-6 is dependent on NF-kappaB , this may explain recent evidence that NO inhibits macrophage IL-6 production
Scicchitano et al., Blood Cells Mol Dis 2008 (MAP Kinase Signaling System) : In addition, these results suggest that IL-6 , IL-11, GM-CSF, G-CSF and Activin A are similarly regulated by p38 and NF-kappaB and that the MEK1, JNK and PKC pathways appear to play a more limited role in modulating cytokine expression in HBMSC
Kikumori et al., Biochem J 2001 : We have recently demonstrated that nuclear factor kappaB (NF-kappaB) mediates the tumour necrosis factor alpha (TNF-alpha) dependent expression of the gene encoding interleukin 6 (IL-6) in rat thyroid FRTL-5 cells cultured in the presence of thyrotropin ( TSH )
Kobayashi et al., Biochem Biophys Res Commun 2003 : Stretch induced IL-6 secretion from endothelial cells requires NF-kappaB activation ... Two NF-kappaB inhibitors, pyrrolidine dithiocarbamanate ( PDTC ) and SN50, or antisense oligodeoxynucleotides for NF-kappaB p65 and p50 suppressed IL-6 mRNA expressions induced by continuous stretch ... In conclusion, continuous stretch induces IL-6 secretion from ECs, most likely through sequential activation of IKKs and NF-kappaB
Medvedev et al., J Biol Chem 1999 : Unlike lipopolysaccharide, C2-ceramide failed to activate NF-kappaB and did not induce production of tumor necrosis factor or interleukin-6
Béraud et al., Proc Natl Acad Sci U S A 1999 : The compound had virtually no effect on tumor necrosis factor- and interleukin-1 induced NF-kappaB activities
Riedemann et al., FASEB J 2004 (MAP Kinase Signaling System...) : Production of IL-6 in neutrophils by LPS was NF-kappaB dependent ( but not on the presence of p50 ) and dependent on phosphorylation of p38-mitogen activated protein kinase ( MAPK ) as well as p44/p42 MAPK ( ERK1/2 ) but not on phosphorylation of c-Jun N-terminal kinases ( JNK1/2 )
Schreck et al., EMBO J 1991 : NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1 , lipopolysaccharide and lectin
Pistolic et al., J Innate Immun 2009 : Using specific inhibitors it was shown that NF-kappaB signaling led to the LL-37 stimulated production of IL-6
Renard et al., Antioxid Redox Signal 2001 : Of the five antioxidants tested, only curcumin was able to inhibit IkappaBalpha degradation upstream and, hence, NF-kappaB DNA binding activity and NF-kappaB dependent expression of IL-6 downstream
Kurokouchi et al., J Bone Miner Res 1998 (Bone Neoplasms...) : An antioxidant, N-acetyl-L-cysteine, significantly attenuated the TNF-alpha dependent increase in these mRNAs, and simultaneously reduced the activation of NF-kappaB by TNF-alpha, indicating that NF-kappaB mediates the TNF-alpha dependent expression of IL-6 and ICAM-1 in ROS17/2.8 cells
Ji et al., Ann Clin Lab Sci 2004 (Disease Models, Animal...) : The results showed that LPS elevated the production of TNF-alpha, IL-6 , and IL-10 and enhanced NF-kappaB activation in rat intestine
Huang et al., J Mol Endocrinol 2009 : Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation ... Ucn also activates nuclear factor kappa B (NF-kappaB) and a NF-kappaB inhibitor blocks Ucn induced IL-6 release ... Finally, the CRH-R antagonists alpha-helical ( 9-41 ) CRH and astressin-2B completely inhibit Ucn induced IL-6 release, as well as activation of ERK, p38, and NF-kappaB
Ruiz-Deya et al., J Endourol 2002 (Inflammation...) : Stimulation of the human urothelial cells by hypoxia, known to activate NF-kappa B, resulted in an increase in the levels of IL-1 and IL-6 transcripts compared with hypoxia exposed cells in the presence of NF-kappa B inhibitors
Hershko et al., Clin Sci (Lond) 2002 : We tested the hypothesis that sodium arsenite inhibits IL-6 production in stimulated enterocytes and that this effect of arsenite is caused by down-regulation of NF-kappaB activity
de Mejia et al., Peptides 2009 (Inflammation) : The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ), interleukin-1beta production ( IC ( 50 ) =13 microM ), nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Suzuki et al., Trends Immunol 2006 : Although each system seems to possess distinct activation mechanisms, interleukin-1 receptor associated kinase ( IRAK)-4 is essential for NF-kappaB activation in Toll-like receptor ( TLR ) and T-cell receptor ( TCR ) signaling pathways
Colombatti et al., Glia 2001 (Multiple Sclerosis) : We found that T-cell adhesion and T-cell soluble factors induce IL-6 gene expression in U251 astrocytes through distinct signaling pathways, respectively, resulting in the activation of NF-kappaB and IRF-1 transcription factors
Stratton et al., Prostate 2002 (Carcinoma...) : Furthermore, testosterone completely abrogated NF kappa B transactivation activity and induction of IL-6 protein expression and mRNA
Koga et al., FEBS Lett 2008 (Arthritis, Rheumatoid) : Inhibitor studies have shown SAA induced IL-6 production to be down-regulated by NF-kappaB inhibition and partially inhibited by p38 or JNK inhibitors
Chou et al., Int J Radiat Oncol Biol Phys 2009 : Radiation transcriptionally induces IL-6 expression in endothelial cells through mitogen activated protein kinase/p38 mediated NF-kappaB/IkappaB ( inhibitor of NF-kappaB ) complex activation
Inoue et al., Proc Natl Acad Sci U S A 2006 (Arthritis, Experimental) : Detailed signaling studies showed that NF-kappaB also contributes to IL-6 production and that TNF-alpha induced NF-kappaB activation is MKK3 dependent
Szczepanski et al., Cancer Res 2009 (Carcinoma, Squamous Cell...) : LPS binding to TLR4 on tumor cells enhanced proliferation, activated phosphatidylinositol 3-kinase/Akt pathway, up-regulated IRAK-4 expression, induced nuclear NF-kappaB translocation, and increased production ( P < 0.05 ) of interleukin (IL)-6 , IL-8, vascular endothelial growth factor, and granulocyte macrophage colony stimulating factor
Pathak et al., J Immunol 2006 : HP0175 induced IL-6 gene expression was critically dependent on TLR4 dependent NF-kappaB and MAPK activation ... The central role of MSK1 was borne out by the fact that silencing of MSK1 expression abrogated HP0175 mediated NF-kappaB dependent IL-6 gene transcription
Xiao et al., J Biol Chem 2008 : Pellino 3b negatively regulates interleukin-1 induced TAK1 dependent NF kappaB activation
Morcos et al., Diabetes 2002 (Diabetes Mellitus, Type 2...) : The AGE- and CML dependent activation of NF-kappaBp65 and NF-kappaB dependent IL-6 expression could be inhibited using the soluble form of the receptor for AGEs (RAGE) ( soluble RAGE [ sRAGE ] ), RAGE-specific antibody, or the antioxidant thioctic acid
D'Addario et al., J Mol Biol 2001 : Epstein-Barr Virus and its glycoprotein-350 upregulate IL-6 in human B-lymphocytes via CD21, involving activation of NF-kappaB and different signaling pathways
Shembade et al., J Virol 2007 : Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and interleukin-1 mediated NF-kappaB activation
Albrecht et al., Cell Signal 2007 : Activation of NF-kappaB by IL-1beta blocks IL-6 induced sustained STAT3 activation and STAT3 dependent gene expression of the human gamma-fibrinogen gene
LaVallie et al., J Biol Chem 2006 (Osteoarthritis) : Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes
Wang et al., Allergy 2005 : Induction of IL-6 in co-culture of bronchial epithelial cells and eosinophils is regulated by p38 MAPK and NF-kappaB
Lixuan et al., Pulm Pharmacol Ther 2010 (Disease Models, Animal...) : The results show that CSE resulted in increasing IL-8, IL-6 and TNF-alpha expression and activation of NF-kappaB
Nai et al., JPEN J Parenter Enteral Nutr 2007 (Adenocarcinoma...) : Administration of PDTC dose dependently inhibited the NFkappaB activation in tumor tissues, inhibited IL-6 synthesis of the tumor cells, and attenuated the wasting of carcass weight, gastrocnemius muscle, and epididymal fat ... These results suggest that PDTC, an inhibitor of NFkappaB, can attenuate the development of cachexia in colon 26 tumor bearing mice through inhibition of IL-6 synthesis regulated by NFkappaB
Fichorova et al., J Infect Dis 2001 (HIV Infections...) : Analysis of molecular and cellular components in cervicovaginal secretions, as well as results from in vitro activation of cervicovaginal epithelial cells and U1/HIV promonocytic cells, showed that multiple N-9 use can promote HIV-1 transmission through interleukin-1 mediated NF-kappaB activation, which leads to chemokine induced recruitment of HIV-1 host cells and increased HIV-1 replication in infected cells
Baeza-Raja et al., Mol Biol Cell 2004 : Finally, we show that interleukin (IL)-6 expression is induced in C2C12 differentiating myoblasts, in a p38- and NF-kappaB dependent manner
Chen et al., J Immunol 2006 : Peptidoglycan induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B ... These results suggest that PGN induced IL-6 production involves COX-2 generated PGE ( 2 ), activation of the EP2 and EP4 receptors, cAMP formation, and the activation of PKA, protein kinase C, p38 MAPK, IKKdbeta, kinase alphabeta, p65 phosphorylation, and NF-kappaB
Wenk et al., J Biol Chem 2004 : As interleukin-6 (IL-6) was earlier shown to mediate the UVA induction of MMP-1, we studied whether PHGPx overexpression might interfere with the NFkappaB mediated IL-6 induction and downstream signaling ... This together with the suppression of UVA irradiation induced IL-6 release in the presence of Trolox, a chain breaker of PCOOH initiated lipid peroxidation, indicates that UVA irradiation induced PCOOHs and subsequent lipid peroxides initiate the NFkappaB mediated induction of IL-6 , which mediates the induction of MMP-1
Yamauchi et al., Fertil Steril 2004 (Endometriosis) : To examine the involvement of nuclear factor-kappaB (NF-kappaB) and mitogen activated protein kinase ( MAPK ) in the induction of interleukin-6 (IL-6) by tumor necrosis factor-alpha (TNF-alpha) in endometriotic stromal cells ( ESC ) ... The NF-kappaB inhibitor ( TPCK ) and MAPK inhibitor ( U0126 ) blocked the TNF-alpha induced IL-6 expression ... These findings demonstrate that NF-kappaB and AP-1 activation is critical for TNF-alpha induced IL-6 expression in endometriotic stromal cells
Liacini et al., Matrix Biol 2002 (Osteoarthritis, Hip) : Inhibition of interleukin-1 stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
Roach et al., Neuroimmunomodulation 2008 (Astrocytoma...) : Although p38 and nuclear factor (NF)-kappaB are essential for the synergistic release of IL-6 , GABA did not affect either p38 phosphorylation or I kappaB-alpha degradation
Dijsselbloem et al., J Immunol 2007 : We previously demonstrated that genistein suppresses TNF-alpha induced NF-kappaB dependent IL-6 gene expression in cancer cells by interfering with the mitogen- and stress activated protein kinase 1 activation pathway ... More particularly, we observe that genistein inhibits IL-6 gene expression by modulating the transcription factor NF-kappaB
Chen et al., J Urol 2003 (Carcinoma, Transitional Cell...) : We evaluated the influence of androgens on BCG induced, NF-kappaB mediated IL-6 expression ... Two pharmacological androgen receptor blockers were used to determine if receptor blockade inhibited the effect of DHT on activation of the androgen response element, NF-kappaB signaling and BCG induced IL-6 expression ... DHT suppressed BCG induced, NF-kappaB mediated signaling and IL-6 expression in a dose dependent manner ... DHT down-regulates NF-kappaB mediated IL-6 expression by human TCC lines in response to BCG
Van Huffel et al., J Biol Chem 2001 : NF-kappaB activation induced by TNF and interleukin-1 is inhibited by overexpression of ABIN-2
Beetz et al., Int J Radiat Biol 2000 : NF-kappaB and AP-1 are responsible for inducibility of the IL-6 promoter by ionizing radiation in HeLa cells ... These results demonstrate that NF-kappaB plays a major role in X-ray-inducible IL-6 expression in HeLa cells
Karadag et al., Blood 2006 (MAP Kinase Signaling System...) : Furthermore, inhibitors of p38 MAPK and cPLA2, but not NF-kappaB and JAK2, signaling pathways inhibited ADAM-9 induced IL-6 production by hOBs ( P < .01 )
Bi et al., Zhonghua Yi Xue Za Zhi 2008 (Diabetes Mellitus, Experimental...) : In the DM rats the IkappaBalpha protein expression in the skeletal muscle was significantly lower ( P < 0.05 ) and the NF-kappaB P65 DNA binding activity increased, and TNF-alpha, IL-1B, and IL-6 expression levels were up-regulated in comparison with the normal control group
Heitmeier et al., J Biol Chem 1998 : Double stranded RNA induced inducible nitric-oxide synthase expression and interleukin-1 release by murine macrophages requires NF-kappaB activation
Kanneganti et al., Nature 2006 (Inflammation) : In contrast, secretion of tumour-necrosis factor-alpha and IL-6 , as well as activation of NF-kappaB and mitogen activated protein kinases ( MAPKs ) were unaffected by cryopyrin deficiency
Luckey et al., J Pharmacol Exp Ther 2002 (Adenoviridae Infections) : The role of nuclear factor-kappaB (NF-kappaB) in IL-6 induction was elucidated using Kupffer cells transduced in vitro with a recombinant adenovirus containing a IkappaBalpha super-repressor resistant to phosphorylation and degradation ( Ad5IkappaB )
Sancéau et al., J Biol Chem 1995 : Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B , and Sp1 transcription factors ... Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha, in monocytic cells, involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter
Vig et al., J Biol Chem 1999 : Modulation of tumor necrosis factor and interleukin-1 dependent NF-kappaB activity by mPLK/IRAK
Libermann et al., Mol Cell Biol 1990 : These results suggest that NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL-6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-6 gene induction
Blumberg et al., J Interferon Cytokine Res 2005 : Extensions of these findings revealed that the Ctx A subunit induces transcriptional activation of proinflammatory genes in addition to TNF-alpha ( interleukin-8 [ IL- 8 ], intracellular adhesion molecule-1 [ ICAM-1 ], and IL-6 ) and that such transactivation is mediated by the transcriptional regulator NF-kappaB
Kannabiran et al., Mol Cell Biol 1997 : The target site is contained within the interleukin response element ( ILRE ), which mediates IL-6 activation by NF-kappa B
Liu et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2009 (Acute Lung Injury...) : Hemin further upregulated the expression of HO-1 mRNA, decreased NF-kappaB activity drastically, and inhibited the serum levels of TNF-alpha and IL-6 significantly ( P < 0.05 )
Chen et al., J Cell Biochem 2003 : Our results suggest that NF-kappaB activation in PIMs followed by phagocytizing lipopolysaccharide resulted in the up-regulation of TNF-alpha, IL-1beta, IL-6 , IL-8, and COX-2, which could be alleviated by dexamethasone