Gene interactions and pathways from curated databases and text-mining

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CASP1 — NLRC4

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lu et al., Biochem Biophys Res Commun 2005 : Nucleotide binding to CARD12 and its role in CARD12 mediated caspase-1 activation ... We further demonstrate that the nucleotide binding site is required for CARD12 mediated caspase-1 activation ... Our data provide insights into the molecular mechanisms of CARD12 mediated caspase-1 activation
Franchi et al., Nat Immunol 2006 (Salmonella Infections) : Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella infected macrophages ... Delivery of flagellin to the macrophage cytosol induced Ipaf dependent activation of caspase-1 that was independent of Toll-like receptor 5, required for recognition of extracellular flagellin
Thalappilly et al., FEBS J 2006 : We also determined the sequence of events that lead to apoptosis upon caspase 1 activation by Ipaf ... Doxorubicin induced apoptosis was potentiated by the expression of caspase 1 ( but not by a catalytic mutant of caspase 1 ) and required endogenous Ipaf ... Caspase 1-dependent apoptosis induced by doxorubicin was also inhibited by Bcl2 and caspase 9s, but caspase 1 activation by activated Ipaf was not inhibited by Bcl2 ... Our results suggest that Ipaf is involved in PTP-S2 induced apoptosis and that caspase 1, when activated by Ipaf, causes release of mitochondrial proteins ( cytochrome c and Omi ) through Bax activation, thereby functioning as an initiator caspase
Amer et al., J Biol Chem 2006 : Activation of caspase-1 in response to Legionella infection also required host Ipaf , but not TLR5
Kanneganti et al., Immunity 2007 (Inflammation) : However, unlike Ipaf dependent caspase-1 activation, stimulation of the pannexin-1-cryopyrin pathway by several intracellular bacteria was independent of a functional bacterial type III secretion system
Lamkanfi et al., J Immunol 2007 (Legionnaires' Disease) : These results indicate that the restriction of intracellular Legionella replication is more complex than previously appreciated and requires both Ipaf dependent caspase-1 activation as well as functional Naip5 signaling
Suzuki et al., PLoS Pathog 2007 (Necrosis) : Thus, Ipaf plays a critical role in caspase-1 activation induced by Shigella independently of flagellin
Franchi et al., Eur J Immunol 2007 (Pseudomonas Infections) : Critical role for Ipaf in Pseudomonas aeruginosa induced caspase-1 activation
Miao et al., Proc Natl Acad Sci U S A 2008 : Ipaf dependent caspase 1 activation could be recapitulated by delivering P. aeruginosa flagellin to the macrophage cytosol
Sutterwala et al., Clin Immunol 2009 (Inflammation) : Macrophages infected with Legionella pneumophila, Salmonella typhimurium, Shigella flexneri, or Pseudomonas aeruginosa activate caspase-1 in an NLRC4 dependent manner leading to macrophage cell death and the release of proinflammatory cytokines ... This review will discuss these findings as well as the role of bacterial type III and type IV secretion systems and flagellin in NLRC4 mediated caspase-1 activation
Franchi et al., Immunol Rev 2009 (Autoimmune Diseases...) : In this review, we focus on the role of Nod1 and Nod2 in host defense and in particular discuss recent finding regarding the role of Nlrc4 , Nlpr1, and Nlrp3 inflammasomes in caspase-1 activation and subsequent release of proinflammatory cytokines such as interleukin-1 beta
Abdelaziz et al., Int J Biochem Cell Biol 2010 (Bacterial Infections...) : However, studies using a variety of pathogens such as Salmonella, Legionella, Shigella and Pseudomonas at high bacterial burdens revealed that Nlrc4 can mediate caspase-1 activation independent of bacterial flagellin
Miao et al., J Clin Immunol 2010 : NLRC4 ( previously named Ipaf ) activates caspase 1 in response to bacterial virulence factors including type III and IV secretion systems ( T3SS and T4SS )
Brodsky et al., Cell Host Microbe 2010 : Here we demonstrate that caspase-1 activation in response to the Yersinia type III secretion system ( T3SS ) requires the adaptor ASC and involves both NLRP3 and NLRC4 inflammasomes
Wu et al., J Clin Immunol 2010 (Listeriosis) : Here, we have used macrophages from AIM2-, NLRC4-, NLRP3-, and ASC-deficient mice to demonstrate that AIM2, NLRC4 , and NLRP3 inflammasomes as well as the adaptor protein ASC all contribute to activation of caspase-1 in Listeria infected macrophages ... Here, we have used macrophages from AIM2-, NLRC4-, NLRP3-, and ASC-deficient mice to demonstrate that AIM2, NLRC4 , and NLRP3 inflammasomes as well as the adaptor protein ASC all contribute to activation of caspase-1 in Listeria infected macrophages
Franchi et al., Frontiers in microbiology 2011 : In macrophages, the activation of caspase-1 induced by Salmonella is mainly mediated by the NLR family member NLRC4 that senses cytosolic flagellin
Cai et al., J Immunol 2012 (Klebsiella Infections...) : In a model of pulmonary P. aeruginosa infection, flagellin was shown to be essential for the induction of NLRC4 dependent caspase-1 activation
Senerovic et al., Cell death & disease 2012 : Endolysosomal leakage is followed by an ICE protease activating factor dependent activation of Caspase-1 in macrophages and cell death
Gomes et al., J Immunol 2013 (Brucellosis...) : In this study, we showed that NLRC4 is not required to induce caspase-1 activation and further secretion of IL-1ß by B. abortus in macrophages