Gene interactions and pathways from curated databases and text-mining

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CASP1 — NLRP3

Pathways - manually collected, often from reviews:

  • KEGG Influenza A: None → Complex of CASP1-NLRP3-PYCARD (protein-compound, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Hoffman et al., Lancet 2004 (Acute Disease...) : Involvement of cryopyrin in activation of caspase 1 and NF-kappaB signalling suggests that it might have a role in many chronic inflammatory diseases
Yu et al., Cell Death Differ 2006 (Inflammation) : However, both cryopyrin and two disease associated cryopyrin mutants induced ASC oligomerization and ASC dependent caspase-1 activation, with the disease associated mutants being more potent than the wild-type ( WT ) cryopyrin, because of increased self-oligomerization
Kanneganti et al., Nature 2006 (Inflammation) : Cryopyrin and ASC are essential for caspase-1 activation and IL-1beta and IL-18 production in response to bacterial RNA and the imidazoquinoline compounds R837 and R848
Mariathasan et al., Nature 2006 (Inflammation) : Macrophages exposed to Gram positive Staphylococcus aureus or Listeria monocytogenes, however, required both ASC and cryopyrin to activate caspase-1 and secrete IL-1beta
Kanneganti et al., J Biol Chem 2006 : Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double stranded RNA
Dorfleutner et al., Infect Immun 2007 (Inflammation) : cPOP2 binds to ASC and PAN1, thereby blocking formation of cryopyrin and PAN1 containing inflammasomes, activation of caspase-1 , and subsequent processing and secretion of bioactive interleukin-1beta
Kanneganti et al., Immunity 2007 (Inflammation) : Cryopyrin is essential for caspase-1 activation triggered by Toll-like receptor ( TLR ) ligands in the presence of adenosine triphosphate ( ATP ) ... Here we demonstrate that cryopyrin mediated caspase-1 activation proceeds independently of TLR signaling, thus dissociating caspase-1 activation and IL-1beta secretion
Marina-García et al., J Immunol 2008 : Caspase-1 activation induced by MDP and ATP required pannexin-1 and Cryopyrin but was independent of Nod2 ... Furthermore, the work provides evidence for distinct roles of Nod2 and Cryopyrin in the regulation of MDP induced caspase-1 activation and IL-1beta secretion
Franchi et al., Immunol Rev 2009 (Autoimmune Diseases...) : In this review, we focus on the role of Nod1 and Nod2 in host defense and in particular discuss recent finding regarding the role of Nlrc4, Nlpr1, and Nlrp3 inflammasomes in caspase-1 activation and subsequent release of proinflammatory cytokines such as interleukin-1 beta
Lamkanfi et al., J Biol Chem 2009 (Inflammation) : We previously showed that bacterial molecules such as lipopolysaccharide (LPS) and peptidoglycan induce activation of caspase-7 through the Cryopyrin inflammasome ... Similarly, Cryopyrin and ASC were required for activation of caspase-7 in macrophages stimulated with zymosan or mannan and ATP ... These results demonstrate that the conserved fungal components zymosan and mannan require ASC and Cryopyrin for caspase-1 activation and IL-1beta secretion and suggest an important role for the Cryopyrin inflammasome during fungal infections
Franchi et al., J Immunol 2009 (Inflammation) : In addition to TNF-alpha, IL-1alpha and IL-1beta promoted caspase-1 activation via Nlrp3 in response to ATP
Abdul-Sater et al., J Biol Chem 2009 (Uterine Cervical Neoplasms) : Elevated levels of reactive oxygen species are responsible for NLRP3 dependent caspase-1 activation in the infected cells
He et al., J Immunol 2010 (Chlamydia Infections...) : TLR2 was required for induction of pro-IL-1beta, whereas the NLRP3/ASC was required for caspase-1 activation and pro-IL-1beta cleavage to produce mature IL-1beta
Brodsky et al., Cell Host Microbe 2010 : Here we demonstrate that caspase-1 activation in response to the Yersinia type III secretion system ( T3SS ) requires the adaptor ASC and involves both NLRP3 and NLRC4 inflammasomes
Wu et al., J Clin Immunol 2010 (Listeriosis) : Here, we have used macrophages from AIM2-, NLRC4-, NLRP3-, and ASC-deficient mice to demonstrate that AIM2, NLRC4, and NLRP3 inflammasomes as well as the adaptor protein ASC all contribute to activation of caspase-1 in Listeria infected macrophages
Verma et al., Arthritis Rheum 2010 (Cryopyrin-Associated Periodic Syndromes...) : M299V is an activating mutation in NLRP3 resulting in elevated spontaneous caspase 1 activity and IL-1beta levels
Jin et al., J Clin Immunol 2010 (Infection) : NLRP3 , a member of the NLR family of cytosolic pattern recognition receptors, along with the adaptor protein ASC, mediates caspase-1 activation via assembly of the inflammasome in response to various pathogen derived factors as well as danger associated molecules
Takeishi et al., Drug Discov Ther 2008 : Cryopyrin/NALP3 mediated caspase-1 activation is involved not only in the immune response to pathogens but also in the stress response to UV irradiation in human skin
Kuipers et al., Anesthesiology 2012 (Ventilator-Induced Lung Injury) : The presence of uric acid in lung lavage, activation of caspase-1 , and NLRP3 inflammasome gene expression in lung tissue were investigated
Rathinam et al., Cell 2012 : TRIF licenses caspase-11 dependent NLRP3 inflammasome activation by gram negative bacteria
Compan et al., Immunity 2012 : Increased extracellular osmolarity prevented caspase-1 activation by different known NLRP3 activators
Hiramoto et al., Exp Dermatol 2012 (Acute Disease...) : This ROS activate NLRP3, and NLRP3 leads to the production of caspase-1 , which subsequently increases IL-1ß, thereby finally inducing inflammation
Carlström et al., Exp Dermatol 2012 (Genetic Predisposition to Disease...) : Polymorphisms in NLRP3 and caspase recruitment domain containing protein ( CARD)8, a negative regulator of caspase-1 activity, have been associated with susceptibility to common inflammatory diseases, such as Crohn 's disease and rheumatoid arthritis
Hedl et al., Am J Physiol Gastrointest Liver Physiol 2013 (Crohn Disease...) : Importantly, we find that, during chronic Nod2 stimulation, NLRP3/NLRP1 inflammasome mediated caspase-1 activation with subsequent IL-1 secretion is essential for the subsequent bifurcation to downregulated proinflammatory cytokines and upregulated bacterial killing ... Importantly, we find that, during chronic Nod2 stimulation, NLRP3/NLRP1 inflammasome mediated caspase-1 activation with subsequent IL-1 secretion is essential for the subsequent bifurcation to downregulated proinflammatory cytokines and upregulated bacterial killing
Case et al., Proc Natl Acad Sci U S A 2013 (Necrosis) : Legionella activation of caspase-11 stimulated activation of caspase-1 through NLRP3 and ASC
Mao et al., Cell Res 2013 (Shock, Septic) : Here we show that nitric oxide ( NO ) inhibited the NLRP3 mediated ASC pyroptosome formation, caspase-1 activation and IL-1ß secretion in myeloid cells from both mice and humans
Gomes et al., J Immunol 2013 (Brucellosis...) : In contrast, we determined that AIM2, which senses Brucella DNA, and NLRP3 are partially required for caspase-1 activation and IL-1ß secretion
Yan et al., Immunity 2013 (Diabetes Mellitus, Type 2...) : Here we show that stimulation of macrophages with ?-3 FAs, including eicosapentaenoic acid ( EPA ), docosahexaenoic acid ( DHA ), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1ß secretion
Dotson et al., J Biol Chem 2013 (Tularemia) : An enhanced activation of caspase-1 and IL-1ß observed in FTL_0325 mutant infected macrophages at 24 h post-infection was independent of both AIM2 and NLRP3
Giordano et al., J Lipid Res 2013 : NLRP3 dependent caspase-1 activation in hypertrophic adipocytes likely induces obese adipocyte death by pyroptosis, a proinflammatory programmed cell death
Haasken et al., Eur J Immunol 2013 : Activation of the NLRP3 inflammasome results in activation of the cysteine protease caspase-1 and the subsequent processing and secretion of the proinflammatory cytokines IL-1ß and IL-18
Jin et al., Nature communications 2013 : LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I mediated caspase-1 inhibition
Kim et al., Immune network 2013 : Of particular interest, CoCl2 induced hypoxic condition considerably inhibited NLRP3 dependent caspase-1 activation in mixed glial cells, but not in bone marrow derived macrophages