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IL6 — NLRP3

Text-mined interactions from Literome

Qiu et al., Innate Immun 2011 (Carcinoma, Squamous Cell) : Stimulation of NLRP3 with E. coli RNA led to the highest induction of TNF-a, IL-6 , IL-12p40, RANTES and IFN-ß, whereas TLR7, TLR3, TLR9, NOD1 and NOD2 agonists had lower effects
Komune et al., J Virol 2011 : Measles virus V protein inhibits NLRP3 inflammasome mediated interleukin-1ß secretion
McGeough et al., J Immunol 2012 (Cryopyrin-Associated Periodic Syndromes...) : In a second model of IL-1ß-driven inflammation, NLRP3 activation by monosodium urate crystals similarly increased IL-6
Zhong et al., Nature communications 2013 : Exposure to particulate crystals can induce oxidative stress in phagocytes, which triggers NLRP3 inflammasome mediated interleukin-1ß secretion to initiate undesirable inflammatory responses that are associated with both autoinflammatory and metabolic diseases