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CASP1 — NOS2

Text-mined interactions from Literome

Heitmeier et al., J Biol Chem 2001 (Diabetes Mellitus, Type 1...) : Selective ICE inhibition attenuates dsRNA + IFN-gamma induced iNOS expression by primary beta-cells
Pelletier et al., J Rheumatol 2001 (Osteoarthritis) : Specific inhibition of either COX-2 or iNOS reduced the level of chondrocyte death and caspase 3
Chen et al., Acta Pharmacol Sin 2002 (Parkinsonian Disorders) : Rg1 has protective effect against MPTP induced apoptosis and this effect may be attributed to enhancing Bcl-2 and Bcl-xl expression, reducing Bax and iNOS expression, and inhibiting activation of caspase-3
Suschek et al., Mol Pharmacol 2002 : Specific inhibition of ICE activity or IL-1beta functionality significantly reduces expression and activity of the iNOS to control values ... In summary, in endothelial cells, AmB strongly augments cytokine induced iNOS expression and activity by increasing the expression and activity of the ICE
Chen et al., Yao Xue Xue Bao 2002 (Parkinson Disease, Secondary) : Ginsenoside Rg1 showed protective effect on MPTP induced apoptosis in the mouse nigral neurons and this effect may be attributable to reducing the expression of iNOS and inhibiting the activation of caspase-3
Liang et al., Cardiovasc Res 2004 (Myocardial Ischemia...) : Administration of L-arginine 10 min before reperfusion markedly decreased TUNEL positive staining cardiomyocytes, reduced myocardial caspase-3 activity, inhibited iNOS expression, and reduced myocardial nitrotyrosine content
Clements et al., Osteoarthritis Cartilage 2004 (Necrosis) : Post-impact culturing was for 21 days in the presence or absence of the iNOS inhibitor, L-NAME, or the broad-spectrum caspase inhibitor, Z-VAD FMK
Nakagawa et al., J Cell Biochem 2005 : TNF-alpha induced decrease in the number of wild-type cells was significantly prevented by culture with caspase-3 inhibitor ( 10 ( -8 ) M ), while LPS- or Bay K 8644 induced decrease in cell number was significantly prevented by caspase-3 inhibitor or N omega-nitro-L-arginine methylester ( NAME ) ( 10 ( -5 ) M ), an inhibitor of nitric oxide ( NO ) synthase
Jüttler et al., Mol Cell Neurosci 2007 (Inflammation) : In summary, we here provide evidence that ICE represents a target for modulating iNOS expression and high-output NO formation in AC and BEC, to our knowledge the first report of a role of ICE in iNOS expression and the advantage of ICE inhibition in attenuating NO mediated inflammation and pathology
Gupta et al., J Am Soc Nephrol 2007 (Acute Kidney Injury...) : Treatment of septic animals with APC reduced blood urea nitrogen, renal pathology, and chemokine expression and dramatically reduced the induction of inducible nitric oxide synthase and caspase-3 activation in the kidney
Chuang et al., Neuropharmacology 2007 (Epilepsy, Temporal Lobe...) : In Sprague-Dawley rats, significant and temporally correlated upregulation of NOS II ( 3-24h ), but not NOS I or II expression, enhanced cytosolic translocation of cytochrome c ( days 1 and 3 ), augmented activated caspase-3 in cytosol ( days 1, 3 and 7 ) and DNA fragmentation ( days 1, 3 and 7 ) was detected bilaterally in the hippocampal CA3 subfield after elicitation of sustained seizure activity by microinjection of kainic acid into the unilateral CA3 subfield
Holohan et al., J Cell Mol Med 2008 (Insulinoma) : Adenoviral mediated expression of iNOS ( AdiNOS ) alone was sufficient to induce caspase activity and apoptosis
Pieper et al., Antioxid Redox Signal 2008 : VitC and MnTmPyP did not alter iNOS expression or decrease NO levels but did inhibit caspase 3 activity
Braun et al., Int J Neurosci 2009 (Disease Models, Animal...) : Inducible nitric oxide synthase mediates hippocampal caspase-3 activation in pneumococcal meningitis
D'Agostino et al., Biol Psychiatry 2012 (Alzheimer Disease...) : According with the neuroprotective profile of PEA observed during behavioral studies, experimental molecular and biochemical markers induced by Ab25-35 injection, such as lipid peroxidation, protein nytrosylation, inducible nitric oxide synthase induction , and caspase3 activation, were reduced by PEA treatment
Wang et al., Brain Res Bull 2012 (Hypoxia-Ischemia, Brain) : In the meanwhile, the microbubbles attenuated the production of inducible nitric oxide synthase , nitric oxide and tumor necrosis factor-alpha, as well as the activation of caspase-3 in insulted side of brain in neonatal rats
Mao et al., Cell Res 2013 (Shock, Septic) : Depletion of iNOS resulted in increased accumulation of dysfunctional mitochondria in response to LPS and ATP, which was responsible for the increased IL-1ß production and caspase-1 activation
Ozkan et al., Antimicrob Agents Chemother 2013 : Our study shows, for the first time in the literature, that caspase mediated apoptosis, iNOS , caspase 1, and calpain 1 are involved in the pathogenesis of colistin associated nephropathy