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NOS2 — SRC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Davis et al., Am J Physiol Heart Circ Physiol 2003
:
Role of
c-Src in regulation of endothelial
nitric oxide synthase expression during exercise training
Hausel et al., Oncogene 2006
:
In the
presence of
Src , 76 % of wild-type ( wt ) iNOS was redistributed to detergent-insoluble domains and
iNOS activity was decreased by 28 % ( P < 0.05 ) despite increased iNOS protein levels
Chang et al., Am J Physiol Lung Cell Mol Physiol 2008
:
We hypothesized that the
Src family tyrosine kinases (STKs) are
involved in the upregulation of arginase and
inducible nitric oxide synthase (iNOS) expression in response to inflammatory stimuli in pulmonary endothelial cells
Tyryshkin et al., J Biol Chem 2010
(Disease Models, Animal...) :
Src kinase mediated phosphorylation
stabilizes inducible
nitric-oxide synthase in normal cells and cancer cells
Wang et al., J Cell Physiol 2011
:
Taken together, these results suggested that in astrocytes, activation of NF-?B by ET ( B ) -dependent
c-Src , PI3K/Akt, and p42/p44 MAPK signalings is
necessary for ET-1 induced
iNOS gene up-regulation