Gene interactions and pathways from curated databases and text-mining

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HES5 — NOTCH4

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Kubo et al., Development 2009 : Interestingly, unlike other developmental contexts in which Hes gene expression is regulated by Notch signaling, Hairy1 expression in the CMZ is regulated by Wnt signaling
Hao et al., Acta Otolaryngol 2012 : Jagged1 mediated Notch signaling regulates hair cell ( HC ) production in a distinct way rather than lateral inhibition mediated by Hes1 and Hes5
Taelman et al., Development 2006 : Here, we show that the Xenopus Hairy related transcription factor ( HRT ) gene XHRT1, and the Hairy/Enhancer of split ( HES ) genes Xhairy1, Xhairy2b, esr9 and esr10, have distinct restricted dynamic expression patterns during pronephros development, and that their expression is regulated by Notch
Batts et al., Hear Res 2009 : These results indicate that the mammalian auditory epithelium retains the ability to regulate Notch signaling and Notch dependent Hes activity in response to cellular trauma and that the signaling is transient
Falk et al., Methods 2012 : Antibody mediated inhibition of Notch efficiently down-regulated transcription of the immediate Notch target gene hairy and enhancer of split 5 (Hes5) in both mouse and human neural stem cells and revealed a redundant regulation of Hes5 in these cells as complete down-regulation was seen only after simultaneous blocking of Notch1 and Notch2
Yu et al., Hepatology 2011 (Reperfusion Injury) : Notch signal blockade resulted in down-regulation of Hes5 , leading to reduced formation of the Hes5-STAT3 complex and hypophosphorylation of STAT3, which further attenuated manganese superoxide dismutase ( MnSOD ) expression and increased ROS and apoptosis ... Finally, forced Notch activation by ligand stimulation or Hes5 overexpression reduced intracellular ROS and protected hepatocytes from apoptosis after I/R injury through the activation of STAT3 and MnSOD expression
Albright et al., J Pharmacol Exp Ther 2013 : Measurements of Notch related toxicity included goblet cell metaplasia in the gut, marginal-zone depletion in the spleen, reductions in B cells, and changes in expression of the Notch regulated hairy and enhancer of split homolog-1 from blood cells
King et al., Biochem Biophys Res Commun 2006 : Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa ... Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate Notch dependent activation of Hrt and Hes expression
Takizawa et al., Nucleic Acids Res 2003 : In this paper, we show that BMP2 enhances Notch induced transcriptional activation of Hes-5 and Hesr-1 in mouse neuroepithelial cells ... Recruitment of p300 to the NIC containing complex was facilitated by activated Smad1, which is suggested to contribute to BMP2 mediated enhancement of Notch induced Hes-5 expression
Iso et al., J Cell Physiol 2003 : HES/E ( spl ) had been the only known effector of Notch signaling until a recent discovery of a related but distinct bHLH protein family, termed HERP ( HES related repressor protein, also called Hey/Hesr/HRT/CHF/gridlock )
Nelson et al., Dev Neurosci 2006 : While Notch activity directly regulates Hes1 and Hes5 elsewhere in the nervous system, it has been unclear whether Hes1 and/or Hes5 are directly regulated by Notch activity in the developing retina ... Here, we report that both Hes1 and Hes5 are directly regulated by Notch activity during retinal development
Lanford et al., Journal of the Association for Research in Otolaryngology : JARO 2000 : These results are consistent with the hypothesis that activation of Notch via Jagged2 acts to inhibit expression of Math1 in cochlear progenitor cells, possibly through the activity of HES5
Xing et al., EMBO Mol Med 2013 (Brain Neoplasms...) : We also found that the activated Notch signalling in CSCs up-regulated HES5 followed by promoting self-renewal of CSCs
Tang et al., Development 2006 : The disruption of Notch signaling by a gamma-secretase inhibitor in an in vitro organ culture system of wild-type cochleae resulted in a reduction in expression of the Notch target gene Hes5 and an increase in hair cell differentiation
Katoh et al., Int J Oncol 2004 : Activation of Notch signaling pathway leads to transcriptional activation of Hes family genes through the interaction between Notch intracellular domain and RBPSUH ( CSL )