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JAK2 — NOX5

Text-mined interactions from Literome

Banes-Berceli et al., Vascul Pharmacol 2005 (Diabetes Mellitus, Experimental) : Endothelin-1 activation of JAK2 in vascular smooth muscle cells involves NAD ( P ) H oxidase derived reactive oxygen species
Wu et al., Br J Pharmacol 2009 : Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity, activation of extracellular regulated kinase (ERK), c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma
Pandey et al., Am J Physiol Heart Circ Physiol 2012 : In HVSMC, angiotensin II, endothelin-1 and TNF-a increased endogenous Nox5 mRNA levels, while adenovirus mediated overexpression of Nox5 promoted p38 MAPK, JAK2 , JNK, and ERK1/2 phosphorylation in endothelial cells ( EC ), but only increased ERK1/2 phosphorylation in HVSMC