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NOX5 — PPP2CA
Text-mined interactions from Literome
Wu et al., Cardiovasc Res 2009
:
Further, iNOS inhibitor 1400W, iNOS deficiency,
NADPH oxidase inhibitor apocynin, or p47phox deficiency
prevented the increase in
PP2A activity and preserved barrier function
Han et al., Free Radic Biol Med 2010
(Sepsis) :
NADPH oxidase inhibitors
prevented PP2A activation and monolayer leak, showing that these changes required reactive oxygen species ... In conclusion, ascorbate acts within microvascular endothelial cells to inhibit septic stimulation of oxidant production by
NADPH oxidase and thereby
prevents PP2A activation, PP2A dependent dephosphorylation and redistribution of occludin, and disruption of the endothelial barrier