Gene interactions and pathways from curated databases and text-mining

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NOX5 — PPP2CA

Text-mined interactions from Literome

Wu et al., Cardiovasc Res 2009 : Further, iNOS inhibitor 1400W, iNOS deficiency, NADPH oxidase inhibitor apocynin, or p47phox deficiency prevented the increase in PP2A activity and preserved barrier function
Han et al., Free Radic Biol Med 2010 (Sepsis) : NADPH oxidase inhibitors prevented PP2A activation and monolayer leak, showing that these changes required reactive oxygen species ... In conclusion, ascorbate acts within microvascular endothelial cells to inhibit septic stimulation of oxidant production by NADPH oxidase and thereby prevents PP2A activation, PP2A dependent dephosphorylation and redistribution of occludin, and disruption of the endothelial barrier