Gene interactions and pathways from curated databases and text-mining

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NPPA — RELA

Text-mined interactions from Literome

Kiemer et al., J Hepatol 2000 (Ischemia...) : 8-Br-cGMP mimicked the effects of ANP on NF-kappaB and AP-1
Tsukagoshi et al., Regul Pept 2001 : ANP inhibited the IFN-gamma induced p38 MAP kinase activation, and ANP and SB203580 inhibited NF-kappaB activation
Kiemer et al., Biochem Biophys Res Commun 2002 : ANP reduced TNF-alpha induced NF-kappaB activity, which was paralleled by a decreased translocation of p65 to nuclei
Moriyama et al., Biochem Biophys Res Commun 2006 : ANP inhibits LPS induced stimulation of rat microglial cells by suppressing NF-kappaB and AP-1 activations ... NF-kappaB and AP-1 activities were enhanced in LPS stimulated microglial cells, and these enhancements were significantly suppressed by ANP ( 10 ( -6 ) M )
Lo et al., J Cell Physiol 2009 : These cells were then stimulated with a high glucose concentration to modulate ANP, TGF-beta1, collagen type I, NF-kappaB and IkappaB-alpha, and the results showed that ANP , TGF-beta1, collagen type I and NF-kappaB significantly increased in untransfected cells, and the transfection of ANP significantly attenuated high glucose activated TGF-beta1, collagen I and NF-kappaB expression