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NQO1 — RELA

Text-mined interactions from Literome

Korashy et al., J Biochem Mol Toxicol 2008 (MAP Kinase Signaling System) : In the current study, we examined the role of redox-sensitive transcription factors, NF-kappaB and AP-1 signaling pathways in the modulation of Nqo1 by heavy metals ... These results clearly demonstrate that activation of NF-kappaB negatively regulates the expression of Nqo1 by heavy metals, whereas AP-1 signaling pathways differentially modulates the heavy metal mediated effects
Dong et al., Exp Mol Med 2010 (Lung Neoplasms) : It has been shown that NQO1 is also essential for the TNF induced activation of NF-kappaB and that beta-lap suppresses the TNF induced NF-kappaB activation ... Irradiation with 4 Gy markedly increased the DNA binding activity of NF-kappaB in A549 cells, but not in the shNQO1 A549 cells, thus demonstrating that NQO1 plays a pivotal role in irradiation induced NF-kappaB activation ... It is concluded that beta-lap suppresses the radiation induced activation of NF-kappaB by interrupting the involvement of NQO1 in the activation of NF-kappaB , thereby inhibiting the transcription of survival signals
Hoshino et al., J Med Chem 2010 : Five resveratrol sulfate metabolites were synthesized and assessed for activities known to be mediated by resveratrol : inhibition of tumor necrosis factor (TNF) alpha induced NFkappaB activity, cylcooxygenases ( COX-1 and COX-2 ), aromatase, nitric oxide production in endotoxin stimulated macrophages, proliferation of KB or MCF7 cells, induction of quinone reductase 1 (QR1) , accumulation in the sub-G ( 1 ) phase of the cell cycle, and quenching of 2,2-diphenyl-1-picrylhydrazyl ( DPPH ) free radical ... Two metabolites showed activity in these assays ; the 3-sulfate exhibited QR1 induction, DPPH free radical scavenging, and COX-1 and COX-2 inhibitory activities and the 4'-sulfate inhibited NFkappaB induction, as well as COX-1 and COX-2 activities