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NR4A2 — VEGFA

Text-mined interactions from Literome

Liu et al., Arterioscler Thromb Vasc Biol 2003 : VEGF increased protein expression of Nurr1 and Nur77 and decreased Nur77 phosphorylation at the negative regulatory site serine 351
Zhao et al., Int J Cancer 2011 (Neovascularization, Pathologic) : VEGF stimulates PKD mediated CREB dependent orphan nuclear receptor Nurr1 expression : role in VEGF induced angiogenesis ... Recent works showed that VEGF potently and rapidly induces expression of orphan nuclear receptor Nurr1 in endothelial cells ... However, the signaling pathway for VEGF induced Nurr1 expression and its role in VEGF induced endothelial cell proliferation and angiogenic response have not been examined ... Transfection of a dominant negative CREB mutant ( K-CREB ) or mutation of this putative CREB site in the Nurr1 promoter attenuates VEGF induced Nurr1 expression ... VEGF also stimulates the binding of nuclear CREB protein to its site in the Nurr1 promoter in vitro and in vivo