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AKT1 — NRF1
Text-mined interactions from Literome
Suliman et al., J Cell Sci 2007
:
Interference with
Akt activity by blocking PI 3-kinase and by mitochondrial targeting of catalase to scavenge H ( 2 ) O ( 2 )
prevented binding of
NRF1 to the Tfam promoter, thereby connecting mitochondrial H ( 2 ) O ( 2 ) to the pathway leading to mtDNA replication
Stetler et al., J Neurochem 2012
(Anoxia) :
AMPK inhibition suppressed NRF1 and TFAM expression by LPS, whereas
PI3K/Akt signaling was
necessary for the nuclear translocation of
NRF1 and subsequent induction of TFAM