Gene interactions and pathways from curated databases and text-mining

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AKT1 — NRF1

Text-mined interactions from Literome

Suliman et al., J Cell Sci 2007 : Interference with Akt activity by blocking PI 3-kinase and by mitochondrial targeting of catalase to scavenge H ( 2 ) O ( 2 ) prevented binding of NRF1 to the Tfam promoter, thereby connecting mitochondrial H ( 2 ) O ( 2 ) to the pathway leading to mtDNA replication
Stetler et al., J Neurochem 2012 (Anoxia) : AMPK inhibition suppressed NRF1 and TFAM expression by LPS, whereas PI3K/Akt signaling was necessary for the nuclear translocation of NRF1 and subsequent induction of TFAM