Gene interactions and pathways from curated databases and text-mining

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MAPK3 — NRG1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Diamonti et al., Proc Natl Acad Sci U S A 2002 : A putative dominant negative form of Nrdp1 potentiates neuregulin stimulated Erk1/2 activity in transfected MCF7 breast tumor cells
Yuste et al., J Biochem 2005 : Analysis of the action of RasN17 indicated that overexpression of this mutant form of Ras did not affect neuregulin or protein kinase C-induced activation of Erk1/2
Di Segni et al., J Mol Neurosci 2006 : Taken together, these results indicate that in PC12-ErbB4 cells, the NRG induced neuroprotective effect from MPP+ treatment, requires PI3K/PKB/Akt and Ras/MapK signaling networks
Bernard et al., J Biol Chem 2012 (Disease Models, Animal...) : Furthermore, in contrast to related ligands, NRG4 enhanced cell survival but not proliferation or migration, and stimulated phosphorylation of the anti-apoptotic mediator Akt but not ERK MAPK
Kim et al., J Neurochem 2013 (MAP Kinase Signaling System) : Stimulation of the ErbB receptors by NRG1ß activated the phosphatidylinositol-3-kinase (PI3K) and mitogen activated protein kinase ( MAPK )
Li et al., ASN neuro 2012 (Demyelinating Diseases) : NRG1 activated MAPK , induced c-Jun expression and promoted a loss of myelin segments in DRG explants isolated from both WT ( wild-type ) and Hsp70 KO ( knockout ) mice