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AKT3 — NTRK2
Text-mined interactions from Literome
Leeds et al., Neurochem Int 2005
:
These results show that neurotrophins protect against AraC induced apoptosis, at least in part, through
TrkB mediated activation of the PI
3-kinase/Akt and MEK signaling pathways
Li et al., Cell Death Differ 2007
(Neuroblastoma) :
Previously, we found BDNF
activation of
TrkB through
PI3K/Akt protects NB from etoposide/cisplatin induced cell death
Qiu et al., Int J Oncol 2006
(Ovarian Neoplasms) :
EGFR and
TrkB kinase inhibitors
inhibited EGF- and BDNF induced TrkB and EGFR activation and
Akt phosphorylation, and cell proliferation and migration
Jin et al., Cancer Res 2007
(Cell Transformation, Neoplastic) :
Here, we define some aspects of the molecular mechanisms regulating
ETV6-NTRK dependent Ras-Erk1/2 and
PI3K-Akt activation
Golder et al., J Neurosci 2008
(Spinal Cord Injuries) :
A2a receptor activation increased phosphorylation and new synthesis of an immature TrkB protein,
induced TrkB signaling through
Akt , and strengthened synaptic pathways to phrenic motoneurons
Zheng et al., J Neurochem 2008
(Ion Channel Gating) :
The
TrkB dependent
Akt phosphorylation at S473 and T308 required only phosphoinositide 3-kinase, but not phospholipase C and mitogen activated protein kinase activity
Saulnier Sholler et al., J Pediatr Hematol Oncol 2009
(Neuroblastoma) :
Nifurtimox also suppressed basal and
TrkB mediated
Akt phosphorylation, and the cytotoxicity of nifurtimox was attenuated by a tyrosine hydroxylase inhibitor ( alpha-methyl-tyrosine )
Ginés et al., J Biol Chem 2010
(Huntington Disease...) :
Here, we demonstrate reduced
TrkB mediated Ras/MAPK/ERK1/2 signaling but unchanged phosphatidylinositol
3-kinase/Akt and phospholipase Cgamma activation in knock-in HD striatal cells
Li et al., Cancer 2011
(Brain Neoplasms...) :
Pretreatment of high TrkB expressing TB3 cells with perifosine blocked
BDNF/TrkB induced
Akt phosphorylation and inhibited BDNF 's protection of TB3 cells from etoposide treatment