Gene interactions and pathways from curated databases and text-mining

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AKT3 — NTRK2

Text-mined interactions from Literome

Leeds et al., Neurochem Int 2005 : These results show that neurotrophins protect against AraC induced apoptosis, at least in part, through TrkB mediated activation of the PI 3-kinase/Akt and MEK signaling pathways
Li et al., Cell Death Differ 2007 (Neuroblastoma) : Previously, we found BDNF activation of TrkB through PI3K/Akt protects NB from etoposide/cisplatin induced cell death
Qiu et al., Int J Oncol 2006 (Ovarian Neoplasms) : EGFR and TrkB kinase inhibitors inhibited EGF- and BDNF induced TrkB and EGFR activation and Akt phosphorylation, and cell proliferation and migration
Jin et al., Cancer Res 2007 (Cell Transformation, Neoplastic) : Here, we define some aspects of the molecular mechanisms regulating ETV6-NTRK dependent Ras-Erk1/2 and PI3K-Akt activation
Golder et al., J Neurosci 2008 (Spinal Cord Injuries) : A2a receptor activation increased phosphorylation and new synthesis of an immature TrkB protein, induced TrkB signaling through Akt , and strengthened synaptic pathways to phrenic motoneurons
Zheng et al., J Neurochem 2008 (Ion Channel Gating) : The TrkB dependent Akt phosphorylation at S473 and T308 required only phosphoinositide 3-kinase, but not phospholipase C and mitogen activated protein kinase activity
Saulnier Sholler et al., J Pediatr Hematol Oncol 2009 (Neuroblastoma) : Nifurtimox also suppressed basal and TrkB mediated Akt phosphorylation, and the cytotoxicity of nifurtimox was attenuated by a tyrosine hydroxylase inhibitor ( alpha-methyl-tyrosine )
Ginés et al., J Biol Chem 2010 (Huntington Disease...) : Here, we demonstrate reduced TrkB mediated Ras/MAPK/ERK1/2 signaling but unchanged phosphatidylinositol 3-kinase/Akt and phospholipase Cgamma activation in knock-in HD striatal cells
Li et al., Cancer 2011 (Brain Neoplasms...) : Pretreatment of high TrkB expressing TB3 cells with perifosine blocked BDNF/TrkB induced Akt phosphorylation and inhibited BDNF 's protection of TB3 cells from etoposide treatment