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IL6 — OPRM1
Text-mined interactions from Literome
Börner et al., Mol Pharmacol 2004
(Inflammation...) :
Transcriptional
regulation of the human
mu-opioid receptor gene by
interleukin-6
Kraus et al., J Neuroimmunol 2006
(Neuroblastoma) :
Earlier investigations demonstrated up-regulated
mu-opioid receptor expression in neuronal and immune cells in
response to IL-1, IL-4,
IL-6 and TNF-alpha
Bonnet et al., Anesth Analg 2008
(Inflammation) :
The
mu opioid receptor mediates morphine induced tumor necrosis factor and
interleukin-6 inhibition in toll-like receptor 2-stimulated monocytes ...
Mu opioid receptor activation specifically
mediated this morphine induced TNF and
IL-6 inhibition in monocytes ... The
mu opioid receptor mediates morphine induced TNF and
IL-6 inhibition in PGN stimulated monocytes, but not in PBMCs
Kraus et al., Front Biosci (Schol Ed) 2009
:
In this review, the
up-regulation of human
mu-opioid receptor gene expression in neuronal and immune effector cells by
interleukin-1 , interleukin-4, interleukin-6 and tumor necrosis factor, as well as its down-regulation by interferon-gamma and granulocyte/macrophage colony stimulating factor will be summarized along with molecular mechanisms, such as transcription factor-promoter-interactions