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OSM — VEGFA

Text-mined interactions from Literome

Vasse et al., Arterioscler Thromb Vasc Biol 1999 : OSM induced only a slight increase in the urokinase receptor and a 60 % increase in VEGF secretion, whereas it does not modify IL-8 secretion or bFGF levels
Weiss et al., Cardiovasc Res 2003 (Myocarditis) : Glycoprotein 130 ligand oncostatin-M induces expression of vascular endothelial growth factor in human adult cardiac myocytes ... OSM , but not CT-1, IL-6 or LIF increased VEGF-1 production in human adult cardiac myocytes dose-dependently derived from five different donors ... When pieces of human myocardial tissue were incubated with the gp130 ligands in an ex vivo model only OSM resulted in an increase in VEGF-1 in the supernatants of these cultures
Repovic et al., Oncogene 2003 (Astrocytoma) : Oncostatin-M induction of vascular endothelial growth factor expression in astroglioma cells ... Specifically examining the OSM contribution to VEGF expression, neutralizing antibodies to OSM receptor subunits gp130 and OSMRbeta, but not LIFRbeta, inhibited OSM induction of VEGF , indicating that the OSM-specific receptor OSMRbeta/gp130 transduces the OSM signal for VEGF synthesis ... OSM induction of VEGF promoter activity maps to the ( -1171, -786 ) region of the VEGF promoter, which contains a STAT-3 binding site ... STAT-3 is indeed essential for this response, since overexpression of a dominant negative STAT-3 blocks OSM induction of VEGF promoter activity, as well as endogenous VEGF expression
Faffe et al., Am J Physiol Lung Cell Mol Physiol 2005 : Oncostatin M causes VEGF release from human airway smooth muscle : synergy with IL-1beta ... Oncostatin M (OSM) , but not other IL-6 family cytokines, increased VEGF release, and IL-1beta enhanced OSM induced VEGF release ... OSM increased VEGF mRNA expression and VEGF promoter activity, whereas IL-1beta had no effect ... IL-1beta did not augment the effects of OSM on VEGF promoter activity but did augment OSM induced VEGF mRNA expression and mRNA stability ... The STAT3 inhibitor piceatannol decreased both OSM induced VEGF release and synergy between OSM and IL-1beta, without affecting responses to IL-1beta alone ... Piceatannol also inhibited OSM induced VEGF mRNA expression ... Consistent with the increase in IL-1R1 expression, OSM markedly augmented IL-1beta induced VEGF , MCP-1, and IL-6 release
Lee et al., Int J Biochem Cell Biol 2007 (MAP Kinase Signaling System) : These results suggest that OSM induces secretion of SDF-1 through ERK-, but not VEGF- , dependent signaling pathways in mesenchymal stem cells
Ehashi et al., J Biomed Mater Res A 2007 : Effects of oncostatin M on secretion of vascular endothelial growth factor and reconstruction of liver-like structure by fetal liver cells in monolayer and three-dimensional cultures ... In the present study, the effects of oncostatin M (OSM) , which strongly stimulates the growth and albumin secretion of FLCs, on VEGF secretion and morphological changes of long-term cultured FLCs were investigated under three-dimensional ( 3-D ) and monolayer conditions ... In conclusion, OSM stimulated the secretion of VEGF by cultured FLCs, which seemed to contribute to the development of a liver-like structure
Ng et al., J Pathol 2007 (Carcinoma, Squamous Cell...) : In the cervical SCC cell lines CaSki and SW756, exogenous OSM activated downstream signalling elements of OSMR including STAT3, p44/42 MAPK, and S6 ribosomal protein, and induced transcription of the angiogenic factor VEGF , effects that were reduced by OSMR depletion using RNA interference
Rega et al., Arterioscler Thromb Vasc Biol 2007 : Furthermore, IL-1beta synergistically enhanced the effect of OSM on VEGF production ... AG-490, a JAK/STAT inhibitor, abolished the OSM dependent VEGF induction almost completely ... We used tissue explants as well as primary cultures of preadipocytes and adipocytes from human subcutaneous and visceral adipose tissue to investigate whether the gp130 ligands oncostatin M (OSM) , interleukin-6 (IL-6), leukemia inhibitory factor (LIF), and cardiotrophin-1 (CT-1) regulate VEGF expression in human adipose tissue ... In mice, IL-6 and OSM increased serum levels of VEGF and VEGF mRNA and vessel density in adipose tissue
Vollmer et al., Hepatology 2009 : In addition, we show that the OSM induced HIF1alpha gene transcription and the resulting enhanced HIF1alpha protein levels are important for the OSM dependent vascular endothelial growth factor and plasminogen activator inhibitor 1 gene induction associated with several diseases
Demyanets et al., Basic Res Cardiol 2011 (Atherosclerosis...) : As inflammation precedes and accompanies pathological angiogenesis, we investigated the effect of OSM and other gp130 ligands on vascular endothelial growth factor ( VEGF ) production in human vascular smooth muscle cells ( SMC ) ... OSM increased VEGF production in both HCASMC and HASMC derived from different donors ... Interferon-? ( IFN-? ), but not IL-4 or IL-10, reduced OSM induced VEGF production in vascular SMC ... IFN-? reduced OSM induced VEGF production by vascular SMC ... STAT3 inhibitor WP1066, p38 MAPK inhibitors SB-202190 and BIRB 0796, extracellular signal regulated kinase1/2 ( Erk1/2 ) inhibitor U0126, and phosphatidylinositol 3-kinase (PI3K) inhibitors LY-294002 and PI-103 reduced OSM induced VEGF synthesis
Fossey et al., BMC cancer 2011 (Neoplasm Invasiveness...) : Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines ... OSM stimulation also resulted in a dose dependent increase in MMP2 activity and VEGF expression that was markedly reduced following treatment with the small molecule STAT3 inhibitor LLL3