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EPHB2 — PAQR3
Text-mined interactions from Literome
Feng et al., Proc Natl Acad Sci U S A 2007
(MAP Kinase Signaling System) :
RKTG expression
inhibits EGF stimulated
ERK and RSK phosphorylation, blocks NGF mediated PC12 cell differentiation, and antagonizes Ras- and Raf-1 stimulated Elk-1 transactivation
Fan et al., Carcinogenesis 2008
(Cell Transformation, Neoplastic...) :
When overexpressed in A375, a human malignant melanoma cell line with B-Raf ( V600E ),
RKTG inhibits
ERK activation, cell proliferation and transformation of A375 cells
Jin et al., Cell Res 2012
(MAP Kinase Signaling System) :
Overexpression of
PAQR10/PAQR11 stimulates basal and EGF induced ERK phosphorylation and
increases the expression of
ERK target genes in a dose dependent manner
Wang et al., Carcinogenesis 2012
(Colorectal Neoplasms...) :
The cell proliferation rate, anchorage independent growth, EGF stimulated
ERK phosphorylation and EGF induced nuclear accumulation of ß-catenin were
inhibited by
PAQR3 overexpression and enhanced by PAQR3 knockdown in SW-480 colorectal cancer cells