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PARP2 — RELA
Text-mined interactions from Literome
Payne et al., Cell Death Differ 1998
:
The pre-treatment of cells with specific inhibitors of these proteins [ pyrrolidine dithiocarbamate (
NF-kappaB inhibitor ) and 3-aminobenzamide (
PARP inhibitor ) ] sensitizes cells to the induction of apoptosis by NaDOC, indicating that these stress response pathways are protective in nature
Hassa et al., Biol Chem 1999
:
Here we show that poly ( ADP ribose ) polymerase (
PARP ) is
required for specific
NF-kappaB transcriptional activation in vivo
Kameoka et al., Biochem J 2000
(Leukemia L1210) :
Taken together, these results strongly suggest that
PARP is
involved in the regulation of
NF-kappaB through the protein modification
Ibuki et al., Biochim Biophys Acta 2003
:
We concluded that ( 1 ) the increase in NO production was due to direct DNA damage by gamma-irradiation, and that ( 2 )
PARP activation through DNA damage
induced NF-kappaB activation, leading to iNOS expression and NO production
Hassa et al., J Biol Chem 2003
:
Furthermore,
PARP-1 interacted directly with p300 and
enhanced the interaction of
NF-kappaB1/p50 to p300
Virág et al., Curr Vasc Pharmacol 2005
(Necrosis) :
Besides serving as a cytotoxic mediator,
PARP-1 is also
involved in transcriptional regulation, most notably in the
NF kappaB and AP-1 driven expression of inflammatory mediators
Koh et al., Toxicology 2005
(Brain Ischemia...) :
We investigated the
effect of poly ( ADP-ribose ) polymerase (
PARP ) inhibitor on the levels of plasma and brain matrix metalloproteinase-9 (MMP-9) and the expression of
nuclear factor kappa B (NF-kappaB) during experimental focal cerebral ischemia ... Therefore, the
PARP inhibitor
reduces the expression of MMP-9 and
NF-kappaB and the infiltration of neutrophils in ischemic stroke
Takahashi et al., Genes Cells 2005
(Pancreatic Neoplasms) :
We found that both
NF-kappaB activation and Bcl-2 family proteins could
prevent the 53BP2S mediated depression of mitochondrial transmembrane potential, activation of caspase-9, cleavage of
poly ADP ribose polymerase ( PARP ) , and cell death
Martin-Oliva et al., Cancer Res 2006
(Cell Transformation, Neoplastic...) :
Inhibition of
PARP also
affected activator protein-1 (AP-1) activation but not
nuclear factor-kappaB (NF-kappaB)
Amiri et al., Oncogene 2006
(Melanoma) :
In its inactive state,
PARP-1 binds to the CXCL1 promoter in a sequence-specific manner and
prevents binding of
NF-kappaB ( p65/p50 ) to its element
Szabó et al., Diabetes 2006
(Body Weight...) :
PARP blockade by INO-1001 and PJ-34
prevented hyperglycemia induced
nuclear factor-kappaB (NFkappaB) activation of podocytes, and it was made evident by the inhibitor of kappaBalpha phosphorylation and NFkappaB p50 nuclear translocation
García et al., Ann Rheum Dis 2008
(Arthritis, Rheumatoid) :
PARP inhibition reduced TNF induced JNK phosphorylation and AP-1 and
NF kappaB binding activities were partially
impaired by treatment with PARP inhibitors or by PARP-1 knockdown
Madinier et al., PloS one 2009
(Brain Infarction...) :
Indeed,
PARP-1 contributes to the activation of the transcription factor
NF-kB , which is essential to the upregulation of proinflammatory genes, in particular responsible for microglial activation/proliferation