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AKT3 — PAWR

Text-mined interactions from Literome

Joshi et al., EMBO J 2008 (Lung Neoplasms) : Par-4 inhibits Akt and suppresses Ras induced lung tumorigenesis ... We also demonstrate in cell culture, in vivo, and in biochemical experiments that Akt regulation by Par-4 is mediated by PKCzeta, establishing a new paradigm for Akt regulation and, likely, for Ras induced lung carcinogenesis, wherein Par-4 is a novel tumour suppressor
Diaz-Meco et al., Cell cycle (Georgetown, Tex.) 2008 (Lung Neoplasms) : Akt regulation and lung cancer : a novel role and mechanism of action for the tumor suppressor Par-4 ... We have demonstrated in cell culture, in vivo, and in biochemical experiments that Akt regulation by Par-4 is mediated by PKC zeta, establishing a new paradigm for Akt regulation and demonstrating in vivo that PKC zeta is a physiologically relevant partner of Par-4