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MAPK1 — PDB1

Text-mined interactions from Literome

Zell et al., Life Sci 2002 (Breast Neoplasms) : In an attempt to determine the upstream signaling pathway, the effects of PDB or DES on the mitogen activated protein kinase ( MAPK ) levels were determined by western blot analysis in the presence and absence of PD098059, a specific inhibitor of mitogen activated protein kinase kinase ( MAPKK ) ... The phospho-MAPK ( p44/42 ) levels, an activated form of MAPK, increased in DES and PDB stimulated cells whereas PD098059 treatment inhibited this increase
Seufferlein et al., Cancer Res 1996 (Carcinoma, Small Cell...) : PD 098059 [ 2- ( 2'-amino-3'-methoxyphenyl ) -oxanaphthalen-4-one ], a selective inhibitor of mitogen activated protein kinase ( MAPK ) kinase 1, prevented activation of p42mapk by PDB in SCLC cells ... The effect of PDB on both p42mapk and p90rsk activation could be prevented by down-regulation of protein kinase C ( PKC ) by prolonged pretreatment with 800 nM PDB or treatment of SCLC cells with the PKC inhibitor bisindolylmaleimide ( GF 109203X ), demonstrating the involvement of phorbol ester-sensitive PKCs in the signaling pathway leading to p42mapk activation