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PDE3B — TNF
Text-mined interactions from Literome
Rahn Landström et al., Biochem J 2000
:
We conclude that the lipolytic
effect of
TNF-alpha involves the down-regulation of
PDE3B , which is associated with increased activation of PKA, presumably owing to increased levels of cAMP ... These results, which suggest that
PDE3B is a novel
target for long-term regulation by
TNF-alpha and cAMP, could contribute to the understanding of the mechanisms of insulin resistance
Molnar-Kimber et al., Agents Actions 1993
:
PDE-IV inhibitors and to a lesser extent,
PDE-III inhibitors
suppressed TNF alpha production
Matsumori et al., J Mol Cell Cardiol 1996
(Heart Failure) :
All three
PDE III inhibitors, amrinone, pimobendan and vesnarinone,
inhibited TNF-alpha production, but vesnarinone 's inhibitory effect was the most prominent