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EPHB2 — PDE4D
Text-mined interactions from Literome
Hoffmann et al., EMBO J 1999
:
The transient form of the EGF induced inhibition of PDE4D3 is thus suggested to be due to feedback regulation by PKA causing the ablation of the
ERK2 induced inhibition of
PDE4D3
Liu et al., J Biol Chem 1999
:
In addition, we show that stimulation of PKC via the associated activation of the
Raf-MEK-ERK cascade results in the phosphorylation and
activation of
PDE4D3 in these cells
Bolger et al., Biochem J 2006
:
siRNA ( small interfering RNA ) -mediated knockdown of RACK1 in HEK-293 ( human embryonic kidney ) B2 cells increased beta-arrestin scaffolded PDE4D5 approx. 5-fold, increased
PDE4D5 recruited to the beta2AR ( beta2-adrenergic receptor ) upon isoproterenol challenge approx. 4-fold and severely
attenuated ( approx. 4-5 fold ) both isoproterenol stimulated PKA ( protein kinase A ) phosphorylation of the beta2AR and activation of
ERK ( extracellular-signal regulated kinase )
Bird et al., Biochem J 2010
:
Interaction with RACK1 was also essential for PKC dependent and
ERK ( extracellular-signal regulated kinase ) -independent phosphorylation ( on Ser1²6 ), and
activation of
PDE4D5 in response to PMA and isoproterenol, both of which trigger the recruitment of PKCa to RACK1