Gene interactions and pathways from curated databases and text-mining

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NFKB1 — PDK1

Text-mined interactions from Literome

Tanaka et al., J Biol Chem 2005 : Here we show that PDK1 can activate IKK/NF-kappaB signaling in addition to Akt signaling to promote cell survival ... IKKalpha is not required for PDK1 mediated NF-kappaB activation because NF-kappaB activation was observed in IKKalpha ( -/- ) mouse embryonic fibroblast (MEF) cells as in wild type MEF cells ... Akt, which was previously reported to activate IKKalpha, did not participate in the PDK1 dependent IKKbeta or NF-kappaB activation
Choi et al., Mol Cells 2005 (MAP Kinase Signaling System) : PI3-kinase and PDK-1 regulate HDAC1 mediated transcriptional repression of transcription factor NF-kappaB ... Even though the crucial involvement of the PI3-kinase/Akt pathway in the anti-apoptotic activation of NF-kB is well known, the exact role of PDK-1 as well as PI3-kinase/Akt in NF-kB activation is not understood ... Here we demonstrate that PDK-1 plays a pivotal role in transcriptional activation of NF-kB by dissociating the transcriptional co-repressor HDAC1 from the p65 subunit of NF-kB ... Etoposide activated NF-kB through PI3-kinase/Akt, and the transcription activation domain ( TAD ) of p65 was further activated by wild-type PDK-1 ... Overexpression of a dominant negative PDK-1 mutant decreased etoposide induced NF-kB transcription and further down-regulated the ectopic HDAC1 mediated decrease in NF-kB transcriptional activity
Parhar et al., Mol Cell Biochem 2007 : We have investigated the role of PKB and PDK1 in IL-1beta induced NF-kappaB activation ... Using a p65-S536A reporter construct, we found inhibition of only PDK1 over-expression induced, but not PKB over-expression induced NF-kappaB activation ... Our data reveals for the first time that PDK1 and PKB may differentially activate NF-kappaB , and that TPCK may subserve a useful anti-inflammatory function by inhibiting IKKbeta
Hayashi et al., Proc Natl Acad Sci U S A 2007 (Asthma...) : Here we report that HAA inhibits NF-kappaB activation upon T cell antigen receptor engagement by specifically targeting PDK1
Kim et al., Mediators Inflamm 2010 : Immunoblotting analysis suggested that CA inhibition was due to the inhibition of phosphoinositide-3-kinase (PI3K) and phosphoinositide dependent kinase (PDK)1 as well as nuclear factor-(NF-) kappaB activation
Chaurasia et al., Mol Cell Biol 2010 (Sepsis) : These experiments reveal a novel PDK-1 dependent negative feedback inhibition of TLR induced NF-kappaB activation in macrophages in vivo