Gene interactions and pathways from curated databases and text-mining

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PECAM1 — RELA

Text-mined interactions from Literome

Botella et al., J Immunol 2000 : Mobility shifts assays identified a specific NF-kappa B-binding element at +110/+120, whose mutation abolished the basal promoter activity of PECAM-1 and decreased NF-kappa B-dependent responses of the PECAM-1 gene promoter ... These results demonstrate that NF-kappa B can regulate the transcriptional activity of PECAM-1
Rui et al., J Immunol 2007 : In this study, we demonstrate that PECAM-1 ligation with CD38-Fc fusion protein negatively regulates LPS induced proinflammatory cytokine TNF-alpha, IL-6, and IFN-beta production by inhibiting JNK, NF-kappaB , and IFN regulatory factor 3 activation in macrophages
Chen et al., Arterioscler Thromb Vasc Biol 2009 (Coronary Restenosis...) : Inward remodeling was associated with PECAM-1 dependent NFkappaB activation, surface adhesion molecule expression, and leukocyte infiltration as well as Akt activation and vascular cell proliferation
Privratsky et al., J Immunol 2010 : To confirm and extend these observations, we examined the effect of engaging, cross linking, or expressing PECAM-1 on NF-kappaB activation in a variety of human cells