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IL12A — PI3

Text-mined interactions from Literome

Fukao et al., Nat Immunol 2002 : We show here that phosphoinositide 3-kinase (PI3K) negatively regulates IL-12 synthesis by DCs
Saegusa et al., Mol Immunol 2007 : The aim of this study was to clarify the role of phosphatidylinositol 3-kinase (PI3K) on the production of interleukine-10 (IL-10) and IL-12 in mouse peritoneal macrophages stimulated with CpG-ODN
Tassi et al., Immunity 2007 : p110gamma played a major role in receptor induced interferon-gamma (IFN-gamma) production through a pathway that involved the kinase ERK and 5-Lipoxigenase, which most likely generates lipid mediators activating GPRCs. Conversely, PI3Ks negatively regulated interleukin-12 (IL-12) and IL-18 induced IFN-gamma by modulating p38 kinase activation
Ohtani et al., Blood 2008 (Leishmaniasis, Cutaneous) : Phosphoinositide 3-kinase (PI3K) negatively regulates Toll-like receptor ( TLR ) -mediated interleukin-12 (IL-12) expression in dendritic cells (DCs)
Mori et al., Eur J Immunol 2012 : The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses
Hildebrand et al., Cell communication and signaling : CCS 2012 : This inhibition of TLR4 induced IL-12p40 expression is mediated by Gai triggered signalling as well as by Gß? dependent activation of PI3kinase and JNK.Taken together we propose the following model : LPS stimulates TLR4 mediated activation of the NF?B-pathway and thereby the production of TNF-a, IL-6 and IL-12p40