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IL8 — PIK3CA

Text-mined interactions from Literome

Al-Okla et al., Cell Microbiol 1999 : However, PI-3K activation is not involved in IL-8 release
Dong et al., Cancer Res 2001 (Carcinoma, Squamous Cell...) : Hepatocyte growth factor/scatter factor induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma ... Inhibitors of MEK ( U0126 ) and PI3K ( LY294002 ) blocked p42/p44 ( erk ) and Akt, respectively, and partially blocked HGF induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A
Shenoy et al., J Immunol 2003 : Inhibition of PI3K activity blocked MBP stimulated O ( 2 ) ( - ) production, but not degranulation or IL-8 production
Huang et al., FEMS Microbiol Lett 2005 (Inflammation) : We show here that inhibition of PI3K in T84 intestinal epithelial cells results in augmentation of Salmonella induced interleukin-8 (IL-8) production at the level of both protein and mRNA
Newcomb et al., J Biol Chem 2005 : Phosphatidylinositol 3-kinase is required for rhinovirus induced airway epithelial cell interleukin-8 expression
Rhee et al., J Biol Chem 2006 : Additionally, we determine that blocking PI3K activation reduces interleukin-8 production induced by flagellin in human colonic epithelial cells
Wrann et al., J Immunol 2007 (Sepsis) : In addition, PI3K inhibition resulted in strongly elevated TLR-4 mediated generation of IL-1beta and IL-8 in neutrophils when these cells were co-stimulated with C5a
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Snoeks et al., Infect Immun 2008 : Additionally, inhibition of PI3K attenuated LPS induced proinflammatory interleukin-8 (IL-8)
Yang et al., Microvasc Res 2009 (AIDS Dementia Complex) : Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly diminished IL-8- , IL-6-, and gp120 induced monocyte adhesion and migration across in vitro BBB models
Takeshima et al., BMC microbiology 2009 (Helicobacter Infections) : PI3K inhibitor suppressed H. pylori induced p65 phosphorylation and NF-kappaB transactivation, as well as interleukin-8 expression
Fernandes et al., Mol Biol Cell 2009 : Although Akt is also activated in response to proteasome inactivation, we found that the PI3K dependent up-regulation of IL-8 is independent of 3-phosphoinositide dependent protein kinase ( PDK)1 and Akt
Westra et al., BMC musculoskeletal disorders 2010 (Arthritis...) : THP-1 and SF macrophages produced high levels of VEGF, IL-8 , and MMP-9, and VEGF protein production was significantly inhibited by PI3K-inhibitor , and by both CaMKII inhibitors
Lin et al., J Biol Chem 2011 : Thrombin induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor ( LY294002 ), an Akt inhibitor ( 1-L-6-hydroxymethyl-chiro-inositol-2- ( ( R ) -2-O-methyl-3-O-octadecylcarbonate ) ), and the dominant negative mutants of Rac1 ( RacN17 ) and Akt ( AktDN )
Bhattacharyya et al., J Biol Chem 2011 (Cystic Fibrosis...) : However, overexpressing SHIP1 or inhibition of PI3K in CF cells suppressed IL-8 expression
Zhang et al., J Cell Physiol 2012 (Carcinoma, Non-Small-Cell Lung...) : EGF stimulated IL-8 production, phosphorylation of Akt and Erk, and cell proliferation and movement could be inhibited by EGFR inhibitor ( Erlotinib ), PI3K inhibitor ( GDC-0941 BEZ-235 and SHBM1009 ), and ERK1/2 inhibitor ( PD98059 )
Lai et al., International journal of biological sciences 2011 : Moreover, we demonstrated that IL-8 activated PI3K following the same kinetics observed from IL-8 induction of cytoskeletal rearrangement, suggesting the participation of PI3K in these processes
Wu et al., Particle and fibre toxicology 2012 (MAP Kinase Signaling System) : Pharmacological inhibition of ERK kinase and PI3K activity blocked DEP induced IL-8 and IL-1ß expression
Britschgi et al., Cancer Cell 2012 (Breast Neoplasms...) : Mechanistically, PI3K/mTOR inhibition increased IRS1 dependent activation of JAK2/STAT5 and secretion of IL-8 in several cell lines and primary breast tumors
Knall et al., Proc Natl Acad Sci U S A 1997 : Recently we reported that IL-8 caused the activation of the Ras/Raf/extracellular signal regulated kinase ( ERK ) pathway in human neutrophils and that this activation was dependent on PI3K activity
Bavelloni et al., J Cell Sci 1999 (Osteosarcoma) : Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells