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PIK3R1 — SRC
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of BCAR1-ESR1-PIK3R1-SRC
→
SRC
(directlyIncreases, BCAR1/ESR1/PIK3R1/SRC Activity)
Cabodi et al., J Cell Sci 2004
Evidence: We show that in the human breast carcinoma T47D cells, upon estrogen treatment, p130Cas rapidly and transiently associates with the estrogen receptor alpha in a multi-molecular complex containing the c-Src kinase and the p85 subunit of PI 3-kinase. Association of p130Cas with the estrogen receptor alpha occurs within 3 minutes of estrogen treatment and is dependent on c-Src kinase activation. Transient overexpression of p130Cas in T47D cells increases estrogen-dependent Src kinase and Erk1/2 MAP...
-
OpenBEL Selventa BEL large corpus:
PIK3R1
→
SRC
(directlyIncreases, PIK3R1 Activity)
Evidence: 8385099;15592455
-
OpenBEL Selventa BEL large corpus:
Complex of BCAR1-ESR1-PIK3R1-SRC
(increases)
Cabodi et al., J Cell Sci 2004
Evidence: We show that in the human breast carcinoma T47D cells, upon estrogen treatment, p130Cas rapidly and transiently associates with the estrogen receptor alpha in a multi-molecular complex containing the c-Src kinase and the p85 subunit of PI 3-kinase. Association of p130Cas with the estrogen receptor alpha occurs within 3 minutes of estrogen treatment and is dependent on c-Src kinase activation. Transient overexpression of p130Cas in T47D cells increases estrogen-dependent Src kinase and Erk1/2 MAP...
-
KEGG VEGF signaling pathway:
SRC
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
NCI Pathway Database Nongenotropic Androgen signaling:
T-DHT/AR/PELP1/Src/PI3K complex (AR-PELP1-SRC-PIK3CA-PIK3R1)
→
T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC)
(modification, collaborate)
Castoria et al., J Cell Biol 2003
Evidence: physical interaction, other species
-
NCI Pathway Database Nongenotropic Androgen signaling:
T-DHT/AR/PELP1/Src/PI3K complex (AR-PELP1-SRC-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Castoria et al., J Cell Biol 2003
Evidence: physical interaction, other species
-
NCI Pathway Database Nongenotropic Androgen signaling:
T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Castoria et al., J Cell Biol 2003
Evidence: physical interaction, other species
-
NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma:
RAS family/GTP/PI3K complex (PIK3CA-PIK3R1-HRAS_KRAS_HRAS_KRAS_NRAS)
→
Src (SRC)
(modification, activates)
Zhang et al., EMBO J 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC)
→
E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1)
(modification, collaborate)
Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
None
→
E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1)
(modification, activates)
Haynes et al., Circ Res 2000, Hisamoto et al., J Biol Chem 2001, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007
Evidence: assay
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1)
→
AKT1 (AKT1)
(modification, activates)
Haynes et al., Circ Res 2000, Hisamoto et al., J Biol Chem 2001, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007
Evidence: assay
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
None
→
E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1)
(modification, collaborate)
Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003
Evidence: mutant phenotype, assay
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
Src (SRC)
→
PI3K complex (PIK3CA-PIK3R1)
(translocation, activates)
Pang et al., J Biol Chem 2005*, Fukuyama et al., Oncogene 2006
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
Src (SRC)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Fukuyama et al., Oncogene 2006
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK)
→
PI3K Class IA family (PIK3CA/PIK3R1/PIK3CB/PIK3R1)
(modification, activates)
Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
-
Reactome Reaction:
PIK3R1
→
SRC
(indirect_complex)
Sun et al., J Biol Chem 2008, Ruan et al., EMBO J 2012
-
Reactome Reaction:
PIK3R1
→
SRC
(reaction)
Sun et al., J Biol Chem 2008, Ruan et al., EMBO J 2012
-
WikiPathways Signaling Pathways in Glioblastoma:
SRC
→
Complex of PIK3R1-PIK3R2-PIK3CA-PIK3CB-PIK3CD
(mim-stimulation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of BCAR1-PIK3R1-SRC
Cabodi et al., J Cell Sci 2004
-
IRef Biogrid Interaction:
SRC
—
PIK3R1
(physical association, affinity chromatography technology)
Song et al., Cell Signal 2010*
-
IRef Biogrid Interaction:
SRC
—
PIK3R1
(physical association, affinity chromatography technology)
Liu et al., FEBS Lett 2010*
-
IRef Biogrid Interaction:
SRC
—
PIK3R1
(physical association, affinity chromatography technology)
Burnham et al., Mol Carcinog 1999*
-
MIPS CORUM p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex:
p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex complex (BCAR1-ESR1-PIK3R1-SRC)
Cabodi et al., J Cell Sci 2004
-
IRef Corum Interaction:
Complex of SRC-ESR1-PIK3R1-BCAR1
(association, anti bait coimmunoprecipitation)
Cabodi et al., J Cell Sci 2004
-
IRef Hprd Interaction:
SRC
—
PIK3R1
(in vivo)
Gentili et al., J Cell Biochem 2002*
-
IRef Intact Interaction:
Complex of ESR1-SRC-PIK3R1
(association, anti bait coimmunoprecipitation)
Poulard et al., EMBO Mol Med 2012*
-
IRef Intact Interaction:
Complex of SRC-ERBB2-PIK3R1-ERBB3
(association, anti bait coimmunoprecipitation)
Liang et al., Cancer Cell 2010*
-
IRef Intact Interaction:
SRC
—
PIK3R1
(physical association, anti bait coimmunoprecipitation)
Liu et al., FEBS Lett 2010*
-
IRef Intact Interaction:
SRC
—
PIK3R1
(physical association, proximity ligation assay)
Liu et al., Mol Cell Proteomics 2013
-
IRef Ophid Interaction:
SRC
—
PIK3R1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
SRC
—
PIK3R1
(aggregation, confirmational text mining)
Gentili et al., J Cell Biochem 2002*
Text-mined interactions from Literome
Amyere et al., Int J Med Microbiol 2002
:
v-Src and K-Ras
activate PI3K and PLC, as demonstrated by in situ production of the corresponding lipid products
Bock et al., J Biol Chem 2003
:
Here we demonstrate that
PI3K activation by Reelin
requires Src family kinase activity and depends on the Reelin triggered interaction of Dab1 with the PI3K regulatory subunit p85alpha
Shenoy et al., J Immunol 2003
:
We conclude that MBP stimulates a
Src kinase dependent
activation of class I ( A )
PI3K and, in turn, activation of PKCzeta in neutrophils, which contributes to the activation of NADPH oxidase and the resultant O ( 2 ) ( - ) production in response to MBP stimulation
Carini et al., Gastroenterology 2004
(Reperfusion Injury) :
PI3K is
activated following hepatocyte hypoxic preconditioning by the combined stimulation of adenosine A 2A receptors, PKA, Galphai protein, and
Src
Facchini et al., FEBS Lett 2005
:
In turn
Src can
activate PI3K and PKC-delta, and all these signaling proteins are required for ODC induction
Díaz-Montero et al., Eur J Cancer 2006
(Osteosarcoma) :
PI3-K/Akt mediated anoikis resistance of human osteosarcoma cells
requires Src activation
Arcaro et al., Cell Signal 2007
(Carcinoma, Small Cell) :
Together our data demonstrate that lipid rafts
play a key role in the activation of
PI3K signalling by facilitating the interaction of
Src with specific PI3K isoforms
Thamilselvan et al., FASEB J 2007
(Colonic Neoplasms...) :
PI3K inhibitor ( LY294002 )
prevented pressure stimulated Akt Ser473 and FAK Tyr397, but not FAK576 or
Src416 phosphorylation
Jin et al., Cancer Res 2007
(Cell Transformation, Neoplastic) :
Suppression of
c-Src by RNA interference in NIH3T3-ETV6-NTRK3 cells
resulted in markedly decreased expression of cyclin D1 and suppression of activation of Ras-Erk1/2 and
PI3K-Akt
Jin et al., J Biol Chem 2008
(Cell Transformation, Neoplastic) :
Suppression of
c-Src by RNA interference in highly metastatic 4T1 mammary cancer cells, which express endogenous TrkC,
resulted in markedly decreased expression of cyclin D1 and suppression of activation of Ras-Erk1/2 and
PI3K-Akt
Lin et al., Toxicol Appl Pharmacol 2008
:
LPS stimulated
Src , PYK2, EGFR, and Akt phosphorylation and VCAM-1 expression were
attenuated by the inhibitors of Src ( PP1 ), EGFR ( AG1478 ),
PI3-K ( LY294002 and wortmannin ), and Akt ( SH-5 ), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110
Gingerich et al., Neuropharmacology 2008
:
Finally, we demonstrate that Src kinase acts upstream of the PI3K/Akt pathway based on our finding that the selective
Src inhibitor, PP2 ( 10microM ),
blocked the increases in nNOS phosphorylation levels, NO production, and
PI3K/Akt activity induced by ERbeta activation
Meng et al., Br J Cancer 2009
(Adenocarcinoma...) :
In addition, the
Src inhibitor, PP2,
blocked the phosphorylation of FAK, ERK1/2,
PI3K , and Akt
Jiang et al., J Biol Chem 2010
(Prostatic Neoplasms) :
Basal tyrosine phosphorylation of p110beta and p110delta could be blocked by
c-Src inhibitors, but this did not
suppress PI3K activity, which was similarly independent of Ras
Lei et al., Am J Physiol Lung Cell Mol Physiol 2011
:
In summary, in adult rat AECs T3-stimulated
Src kinase activity can
activate both
PI3K/Akt and MAPK/ERK1/2, and activation of Akt is necessary for T3-induced Na-K-ATPase activity
Lin et al., Science signaling 2011
:
These phosphorylation events enabled direct binding of GIV to the amino- and carboxyl-terminal
Src homology 2 domains of p85a, a regulatory subunit of PI3K ; stabilized receptor association with PI3K ; and enhanced
PI3K activity at the plasma membrane to
trigger cell migration
Samoylenko et al., Carcinogenesis 2012
(Adenocarcinoma...) :
Thereby, Ruk ( l )
/CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of
Src , Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility
Busch et al., J Biol Chem 2012
:
IL-1ß induced NF-?B and
PI3K activation was
inhibited by resveratrol or the inhibitors of PI3K ( wortmannin ),
c-Src ( PP1 ), and Akt ( SH-5 ) through inhibition of I?B kinase, I?Ba phosphorylation, and inhibition of nuclear translocation of NF-?B, suggesting that PI3K signaling pathway may be one of the signaling pathways inhibited by resveratrol to abrogate NF-?B activation