Gene interactions and pathways from curated databases and text-mining

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IL1B — PLA2G4A

Text-mined interactions from Literome

Higashi et al., Inflamm Res 2000 : Augmented PGE2 production by mineralizing osteoblasts after IL-1beta treatment, and the involvement of IL-1beta induced cPLA2 , sPLA2, COX-2 and PGE synthase activities in this phenomenon were demonstrated
Hayashi et al., Cytokine 2000 : IFN-gamma and IL-4 dramatically inhibited the IL-1beta induced delayed PGE ( 2 ) generation ; these cytokines apparently suppressed IL-1beta stimulated COX-2 expression and only weakly suppressed cPLA(2)expression in response to IL-1beta
Sampey et al., Arthritis Rheum 2001 (Arthritis, Rheumatoid) : Interleukin-1beta (IL-1beta) significantly up-regulated PLA2 activity ( P < 0.005 ) and cPLA2 mRNA expression while anti-MIF monoclonal antibody ( mAb ) significantly inhibited this IL-1beta induced PLA2 activity ( P < 0.02 )
Wang et al., Cell Biochem Funct 2004 : The mediating role of cPLA2 in IL-1 beta and IL-6 release in LPS induced HeLa cells
Cao et al., J Pharmacol Exp Ther 2004 (Colitis, Ulcerative) : IL-1beta significantly increased the phosphorylation of extracellular signal regulated kinase 1 ( ERK1 ) /ERK2 MAPKs and cPLA(2) and IL-1beta induced cPLA(2) phosphorylation was blocked by PD98059
Vichai et al., Inflamm Res 2005 : None of the PG metabolites tested showed significant effects on the level of COX-1 or cPLA2 protein expression, except for PGF2alpha, which increased IL-1beta induced cPLA2 protein expression slightly
Sun et al., Placenta 2006 : Both dexamethasone and IL-1beta stimulated cPLA(2) promoter-driven luciferase reporter gene activity
Cao et al., Am J Physiol Gastrointest Liver Physiol 2006 (Calcium Signaling) : IL-1beta induced cPLA(2) phosphorylation was blocked by SB-203580 but not by AACOCF3, suggesting sequential activation of p38 MAPK phosphorylating cPLA(2)
Sooranna et al., Mol Hum Reprod 2006 : In primary cultures of uterine myocytes, cPLA(2) mRNA expression was increased by IL-1beta and IL-6 ; PGHS-2 mRNA expression was increased by IL-1beta , PGE ( 2 ) and stretch ; and PGES-1 mRNA expression was increased by IL-1beta only
Thampatty et al., Gene 2007 (MAP Kinase Signaling System) : We found that IL-1beta increased the expression levels of cPLA(2) and COX-2, and also increased the secretion of PGE ( 2 )
Chenevier-Gobeaux et al., Life Sci 2007 (Arthritis, Rheumatoid...) : cPLA(2) inhibitors inhibited both IL-1beta and TNF-alpha induced superoxide production in RA and OA cells ... Basal PLA(2) activity was significantly more important in RA cells than in OA cells ; PLA(2) activity was increased in IL-1beta and TNF-alpha pre treated RA cells, and cPLA(2) inhibitors inhibited this activity
Wang et al., Prostaglandins Other Lipid Mediat 2008 : p38 MAPK inhibitor SB203580 suppressed interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) release, as well as the activation of cPLA(2)
Luo et al., Toxicol Appl Pharmacol 2008 : However, the mechanisms underlying IL-1beta induced cPLA2 expression and PGE2 synthesis by canine tracheal smooth muscle cells ( CTSMCs ) have not been defined ... Furthermore, IL-1beta induced cPLA2 expression and PGE2 synthesis was inhibited by a selective NF-kappaB inhibitor ( helenalin ) or transfection with dominant negative mutants of NF-kappaB inducing kinase (NIK), IkappaB kinase (IKK)-alpha, and IKK-beta ... IL-1beta induced cPLA2 expression and PGE2 production was inhibited by actinomycin D and cycloheximide, indicating the involvement of transcriptional and translational events in these responses ... These results suggest that in CTSMCs, IL-1beta induced cPLA2 expression and PGE2 synthesis was independently mediated through activation of MAPKs and NF-kappaB pathways and was connected to p300 recruitment and activation
Ling et al., Mol Carcinog 2010 (Carcinoma, Non-Small-Cell Lung...) : Our results showed that PA ( 1 ) inhibited anchorage dependent and -independent A549 growth in a concentration dependent manner, ( 2 ) induced apoptosis and disrupted mitochondrial membrane potential in A549 cells, and at nonlethal levels, ( 3 ) decreased IL-1 beta induced activation of cPLA(2) and COX-2, ( 4 ) suppressed IL-1 beta induced activation of mitogen activated protein kinases ( MAPKs ), and ( 5 ) inhibited IL-1 beta stimulated nuclear factor kappa B (NF-kappaB) signaling pathways
Angel et al., Eur J Biochem 1994 : In order to identify the enzymes that are linked to IL-1 mediated arachidonate availability and subsequent PGE2 production, we have investigated the changes in gene expression of the 85-kDa cytosolic PLA2 (cPLA2) , the 14-kDa secretory PLA2 ( sPLA2 ) and the two forms of cyclooxygenase in human synoviocytes after stimulation with recombinant IL-1 beta
Schalkwijk et al., FEBS Lett 1993 : This effect of IL-1 beta on the cPLA2 activity is inhibited by actinomycin D and cycloheximide, indicating that both transcription and translation are involved ... In parallel with the effect of dexamethasone on the sPLA2, this glucocorticoid inhibits the IL-1 beta enhanced cPLA2 activity as a result of the suppression of IL-1 beta induced cPLA2 gene expression
Xue et al., Prostaglandins 1996 : In previous studies we have shown that IL-1 beta induced both PGE2 release and total cellular cPLA2 activity and cPLA2 protein synthesis in human amnion derived WISH cells ... In this study, the effect of IL-1 beta on cPLA2 and PGHS-2 mRNA expression was investigated ... Using RT-PCR, we found that IL-1 beta ( 0.1 ng/ml ) coordinately induced both cPLA2 and PGHS-2 mRNA expression within 2 hours ... The synthetic glucocorticoid dexamethasone ( 10 ( -10 ) -10 ( -6 ) M ) inhibited IL-1 beta induced cPLA2 and PGHS-2 mRNA expression activity and protein synthesis and PGE2 release in a concentration dependent manner ... In addition, cycloheximide ( 5 micrograms/ml ) apparently superinduced, but actinomycin D ( 2 micrograms/ml ) inhibited IL-1 beta induced cPLA2 and PGHS-2 mRNA expression suggesting that both are immediate early genes and a transcriptional mechanism is involved in the induction of both cPLA2 and PGHS-2 mRNA by IL-1 beta
Dimitrov et al., J Virol 1997 : Ad infection did not inhibit cPLA2 translocation in response to interleukin-1beta or platelet derived growth factor