◀ Back to NFKB1
NFKB1 — PLAU
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Sliva et al., J Biol Chem 2002
(Breast Neoplasms...) :
The urokinase-type plasminogen activator ( uPA ) promoter contains an NF-kappaB binding site, and
uPA expression in MDA-MB-231 cells is
induced by the constitutively active
NF-kappaB ... Furthermore, inhibition of
NF-kappaB markedly attenuated endogenous migration, and inhibition of PI 3-kinase and NF-kappaB
reduced secretion of
uPA
Abraham et al., J Immunol 2003
(Acute Disease) :
In particular,
uPA increased LPS induced activation of intracellular signaling pathways, including Akt and c-Jun N-terminal kinase, nuclear translocation of the transcriptional regulatory factor
NF-kappa B , and expression of proinflammatory cytokines, including IL-1 beta, macrophage-inflammatory protein-2, and TNF-alpha
Das et al., J Biol Chem 2003
(Breast Neoplasms) :
To our knowledge, this is first report that OPN induces NFkappaB activity and uPA secretion by activating PI 3'-kinase/Akt/IKK mediated signaling pathways and further demonstrates a functional molecular link between OPN induced PI 3'-kinase dependent Akt phosphorylation and
NFkappaB mediated
uPA secretion, and all of these ultimately control the motility of breast cancer cells
Lloyd et al., Int J Oncol 2003
(Neoplasm Invasiveness...) :
We have recently demonstrated that constitutively active
nuclear factor-kappa B (NF-kappaB) is
responsible for the increased secretion of
uPA and that inhibition of NF-kappaB suppresses secretion of uPA and cell migration of highly invasive cancer cells
Das et al., IUBMB Life 2005
(Disease Progression...) :
Taken together, OPN induces NFkappaB activity and uPA secretion by activating PI 3'-kinase/Akt/IKK mediated signaling pathways and further demonstrates a functional molecular link between OPN induced PI 3'-kinase dependent Akt phosphorylation and
NFkappaB mediated
uPA secretion, and all of these ultimately control the motility and invasiveness of breast cancer cells
Iwamoto et al., Scand J Gastroenterol 2005
(Helicobacter Infections...) :
To evaluate the
role of transcription factor
NF-kappaB in
uPA and uPAR gene transcription with H. pylori stimulation, the effect of NF-kappaB inhibitor MG132 on H. pylori induced uPA and uPAR mRNA expression was examined
Zhang et al., Pancreas 2006
(Neoplasm Invasiveness...) :
Subsequently, the EGF induced MMP-9 and
uPA expression and MMP-9 activity, as well as cell invasiveness, were also
inhibited by these
NF-kappaB inhibitors ... Our findings indicated that
NF-kappaB mediated MMP-9 and
uPA induction was responsible for EGF induced invasiveness in these pancreatic cancer cell lines and implicate that such anti-NF-kappaB therapy as the use of NF-kappaB inhibitors may contribute to the reduction of invasiveness of pancreatic cancer
Rangaswami et al., Glycoconj J 2006
(Melanoma) :
Taken together, NIK acts as crucial regulator in OPN induced MAPK/IKK mediated
NF-kappaB dependent
uPA secretion and MMP-9 activation thereby controlling melanoma cell motility and chemoinvasion
Jin et al., Mol Cancer Res 2007
(Neoplasm Invasiveness...) :
SN50, a specific inhibitor of
NF-kappaB , which could inhibit in vitro invasive and migratory abilities of gastric cancer cells,
reduced expression of
uPA and MMP9 proteins and increased expression of TIMP1 protein
Ornstein et al., Nutr Cancer 2007
(Neoplasm Invasiveness...) :
Expression of
uPA is
regulated in part by the oxidant-sensitive transcription factor,
NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI )
Zhang et al., Zhonghua Zhong Liu Za Zhi 2007
(Neoplasm Invasiveness...) :
[ Epidermal growth factor mediated
NF-kappaB activation
promotes uPA expression and invasiveness in pancreatic cancer cells ] ... Subsequently, the EGF induced
uPA expression and invasiveness were also
inhibited by
NF-kappaB inhibitor ... Our findings indicated that
NF-kappaB mediated up-regulation of
uPA expression is responsible for EGF induced invasiveness in pancreatic cancer cells, and implicate that such anti-NF-kappaB therapy with NF-kappaB inhibitors may contribute to the reduction of invasiveness of pancreatic cancer
Novak et al., Nucleic Acids Res 1991
:
Our results suggest that maximal transcriptional activation of the
uPA gene by PMA, IL-1 and TNF alpha
requires the induction of
NFkB activity and the decay of a short lived repressor protein, possibly IkB
Cicek et al., Clin Exp Metastasis 2009
:
The BRMS1 metastasis suppressor was recently shown to negatively regulate NF-kappaB signaling and down regulate
NF-kappaB dependent
uPA expression
Wu et al., Cancer Lett 2009
(Carcinoma, Hepatocellular...) :
Inhibition of
NF-kappaB activity significantly reduced proliferation and invasion of Hep3B cells as well as
down-regulated the expression of invasion related molecules including matrix metalloproteinase (MMP)-2, MMP-9, membrane type-1 MMP (MT1-MMP),
urokinase plasminogen activator (uPA) and vascular endothelial growth factor ( VEGF )
Tobar et al., Mol Cell Biochem 2010
:
Our results shows that TGF-beta1 stimulation of
uPA and MMP-9 expression
involve NOXs dependent ROS and
NFkappaB , activation, demonstrated by using DPI, NOXs inhibitor, ROS scavenger N-acetylcysteine and SN50, an NFkb inhibitor ... Thus,
ROS-NFkappaB acts as the crucial signal in TGF-beta1 induced
uPA and MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1
Uchino et al., Blood Coagul Fibrinolysis 2010
(Neoplasm Invasiveness...) :
NFkappaB dependent regulation of
urokinase plasminogen activator by proanthocyanidin-rich grape seed extract : effect on invasion by prostate cancer cells ... Additional studies showed that GSE inhibited DNA binding activity of the transcription factor nuclear factor kappa B (NFkappaB), which in turn decreased
NFkappaB dependent
uPA transcription
Guerrini et al., FEBS Lett 1996
:
Using the protein synthesis inhibitor cycloheximide and the antioxidant PDTC, that have an opposite effect on NF-kappa B and AP-1 activation, we showed that
uPA mRNA induction by TNF-alpha and PMA in the A549 cell line is mainly
due to
NF-kappa B activation