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MAPK1 — POLDIP2

Text-mined interactions from Literome

Lotem et al., Proc Natl Acad Sci U S A 1999 : The results indicate that ( i ) Ca ( 2+ ) - mobilizing compounds activate different and opposing pathways that diverge downstream from calcineurin activation that can either suppress or induce apoptosis in the same cells ; ( ii ) p38 MAPK but not p44/42 MAPK is involved in induction of apoptosis but not in its suppression by the Ca ( 2+ ) -mobilizing compounds ; and ( iii ) neither p38 nor p44/42 MAPKs mediate induction of apoptosis by some calcineurin independent pathways
Pampolina et al., Thromb Res 1999 : The object of the present study was to examine the role of the p38MAPK in platelet function using anisomycin, a reported activator of p38MAPK , and SB203580, an inhibitor of p38MAPK
Wong et al., Int Arch Allergy Immunol 2000 : Sodium salicylate induced apoptosis of human peripheral blood eosinophils is independent of the activation of c-Jun N-terminal kinase and p38 mitogen activated protein kinase
Bell et al., J Biol Chem 2000 : Thus, we propose that the stimulated expression of enzymatically active Sgk after sorbitol treatment is a newly defined component of the p38 MAPK mediated response to hyperosmotic stress
Moore et al., J Appl Physiol 2001 : Although IL-1 beta and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation, combined administration of the cytokines did not enhance either nuclear factor-kappa B or mitogen activated protein kinase activation
Bhowmick et al., J Biol Chem 2001 : In summary, TGF-beta mediated p38MAPK activation is dependent on functional integrin beta(1), and p38MAPK activity is required but is not sufficient to induce EMT
Du et al., Proc Natl Acad Sci U S A 2001 (MPTP Poisoning...) : Further, minocycline also inhibits NO-induced phosphorylation of p38 mitogen activated protein kinase ( MAPK ) in CGN and the p38 MAPK inhibitor, SB203580, blocks NO toxicity of CGN
Nagano et al., Int Immunol 2002 : Taken together, these results suggest that both ERK and p38 ( MAPK ) pathways are involved in LPS induced COX-2 expression and PGE ( 2 ) production in neutrophils, and IL-10 and IL-4 inhibit neutrophil prostanoid synthesis by down regulating the activation of p38 ( MAPK )
Li et al., Am J Physiol Heart Circ Physiol 2002 (Myocardial Infarction...) : The activity of p38 MAPK was increased during I/R ( P < 0.01 vs. sham control ), and use of LOX-1 antibody inhibited p38 MAPK activation ( P < 0.01 )
Nick et al., J Immunol 2002 (Inflammation) : Release of TNF-alpha, macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ), and IL-8 by LPS stimulated neutrophils was also reduced by poststimulation p38 MAPK inhibition
Heijink et al., Immunology 2002 : This is not the case for the short-term IL-6 effect on IL-5 secretion, where the p38 mitogen activated protein kinase dependent induction of activator protein-1 DNA binding activity is involved, independent of signal transducer and activator of transcription 3 phosphorylation
Natarajan et al., Endocrine 2002 : In summary, in H295R cells, ANG II activated ERK and p38 MAPKs, ANG II-induced p38 MAPK was mediated by 12-LO activation, and ANG II-induced aldosterone synthesis was prevented by 12-LO- and p38 MAPK-specific inhibitors
Sorensen et al., Mol Pharmacol 2003 : Comparison of the intracellular signaling pathways of glial PAR-1, LPA, and S1P receptors indicates that each receptor class activates multiple downstream signaling pathways, including Gq/11 directed inositol lipid/Ca2+ signaling, Gi/o activation of mitogen activated protein kinases ( MAPK ) ( extracellular signal regulated kinase 1/2 and stress activated protein kinase/c-jun N-terminal kinase, but not p38 ), and activation of Rho pathways
Hsu et al., Biochem Pharmacol 2004 : However, none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ), a p38 mitogen activated protein kinase ( MAPK ) inhibitor, 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ), a MAPK kinase ( MEK ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ), a protein kinase C ( PKC ) inhibitor
Bernassola et al., J Exp Med 2004 : p38 mitogen activated protein kinase mediated phosphorylation of p73 is required for p73 recruitment into the PML-NB and subsequent PML dependent p73 stabilization
Wu et al., Cell Biochem Funct 2004 : The Ox-LDL induced TGF-beta(1) promoter activation was also prevented by inhibitors of protein kinase C, but not by p38 mitogen activated protein kinase
Park et al., J Invest Dermatol 2004 (MAP Kinase Signaling System) : The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of ERK and JNK but not by p38 MAPK inhibition
Studer et al., J Orthop Res 2005 : These studies compare actions of p38 MAPK inhibition and COX2 inhibition to modulate human arthritic chondrocyte responses to TGF-beta and FCS under basal and IL-1 activated conditions ... p38 MAPK inhibition and COX2 inhibition have unique and similar abilities to counteract some of the effects of IL-1 on human chondrocyte/cartilage metabolism ... p38 MAPK inhibition blunts TGF-beta stimulation of proteoglycan synthesis, but increases TIMP-1 synthesis
Shin et al., Biol Pharm Bull 2005 : We show that among the mitogen activated protein kinase family activation of phosphorylation of extra cellular signal regulated kinase 1/2 ( ERK1/2, p44/42 ) and p38 , but not c-jun NH2-terminal kinase is inhibited
Ahmed et al., J Nutr 2005 : IL-1beta induced phosphorylation of p38-MAPK , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase, was most susceptible to inhibition by low doses of PFE, and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay
Westra et al., Ann Rheum Dis 2006 (Carcinoma, Hepatocellular...) : For p38 MAPK inhibitor treatment in RA SAA might be a better marker of disease activity than CRP and fibrinogen, because SAA is not directly affected by p38 MAPK inhibition
Jia et al., Zhonghua Wai Ke Za Zhi 2005 (Disease Models, Animal...) : Similarly, the increased gene expression of proinflammatory cytokines TNF-alpha and IL-1beta in gastric mucosa induced by WIR stress were significantly diminished by p38 MAPK inhibition
Cheng et al., Biotechnol Appl Biochem 2006 : The highly specific p38- or JNK-MAPK inhibitors strongly reduced respectively the p38- or JNK-like MAPK phosphorylation, which also demonstrated that there were no cross-reactions between the p38-like MAPK and JNK-like MAPK in T. cuspidata cells
Monsalve et al., J Immunol 2006 (Inflammation) : After treatment with LPS and/or IFN-gamma, we observed a p38 MAPK dependent increase in Notch-1 and Jagged-1 mRNA and protein levels
Song et al., Mol Cells 2006 : Taken together, our data suggest that ET-1 causes p38 MAPK dependent expression of COX-2 by interacting with ETB receptors on ESMC
Xiao et al., Nutr Cancer 2006 : DATS treatment also caused activation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not c-Jun NH2-terminal kinase (JNK) or p38 mitogen activated protein kinase ( p38MAPK ) .DATS-mediatedapoptosis induction and inhibition of HUVEC tube formation was partially but statistically significantly attenuated by pharmacologic inhibition of ERK1/2 but not JNK or p38MAPK
Clarke et al., J Biol Chem 2007 (Lung Neoplasms) : Furthermore, the translocation of nSMase2 was regulated by p38-alpha MAPK, but not ERK or JNK, and the increase in endogenous N-SMase activity was abrogated by p38 MAPK inhibition
Shastry et al., Kidney Int 2007 : We conclude that in MC, Hcy ( i ) activates p38-MAPK and increases p38MAPK nuclear translocation via an oxidative stress dependent mechanism and ( ii ) induces DNA damage and apoptosis that is dependent on oxidative stress and p38-MAPK activation
Ptasinska et al., FASEB J 2007 : NO* dose dependently activated p38 MAPK, and p38 MAPK inhibition with SB202190 or knockdown with siRNA was shown to block NO* activation of PPARgamma
Hickson et al., Mol Reprod Dev 2007 (MAP Kinase Signaling System) : PP2Cdelta ( Ppm1d, WIP1 ), an endogenous inhibitor of p38 MAPK, is regulated along with Trp53 and Cdkn2a following p38 MAPK inhibition during mouse preimplantation development ... This study was conducted to investigate whether PP2Cdelta ( Ppm1d, WIP1 ) is expressed during mouse preimplantation development and to determine the influences of p38 MAPK inhibition on expression of Trp53 ( p53 ), Ppm1d, ( WIP1 ), and Cdkn2a ( p16 ) during mouse preimplantation development
Ekstrand-Hammarström et al., Clin Exp Immunol 2007 : These effects were preceded by reduced activation of the mitogen activated protein kinases ( MAPK ), extracellular signal regulated kinase ( ERK1/2 ) and p38 , as well as down-regulation of nuclear factor-kappaB
Park et al., Mol Cancer Ther 2007 (Neoplasms) : These results indicate that phytosphingosine in combination with As ( 2 ) O ( 3 ) induces synergistic apoptosis in As ( 2 ) O ( 3 ) -resistant leukemia cells through the p38 MAPK mediated mitochondrial translocation of Bax and the PARP-1 activation, and that p38 MAPK and PARP-1 activations are reactive oxygen species dependent
Yano et al., Circ Res 2007 (Inflammation) : Statins activate peroxisome proliferator activated receptor gamma through extracellular signal regulated kinase 1/2 and p38 mitogen activated protein kinase dependent cyclooxygenase-2 expression in macrophages
Xu et al., J Biol Chem 2007 : Activation of bile acid biosynthesis by the p38 mitogen activated protein kinase ( MAPK ) : hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expression
Schwertz et al., Proteomics 2007 (Myocardial Reperfusion Injury...) : p38 MAPK inhibition significantly reduced the phosphorylation of VDAC-1 which is a known mitochondrial regulator of cell survival
Gomes et al., Neurosci Lett 2008 (Neuroblastoma) : Pretreatments with the pan caspase inhibitor, z-VAD-fmk, prevented the apoptosis induced by VEGFR2 inhibition and promoted survival in serum starved cells irrespective of p38 MAPK inhibition
Huang et al., Journal of molecular signaling 2008 : It appears that this effect is mediated through p38 MAPK, because RA decreased p38 phosphorylation, and a selective inhibitor of p38 MAPK ( SB203580 ) also inhibited the phosphorylation of ATF-2
Suzuki et al., Cytokine 2008 (Hemorrhage...) : Two hours thereafter, T cell production of IL-2 and IFN-gamma and activation of MAPK ( p38 , ERK-1/2 and JNK ) were determined
Ding et al., Stem Cells Dev 2008 : Although p38MAPK ( mitogen activated protein kinase ), extracellular signal regulated kinase ( ERK ), and c-Jun N-terminal protein kinase (JNK) were spontaneously activated in early differentiation, only the phosphorylation of p38MAPK was enhanced and prolonged when icariin was present, whereas both ERK and JNK showed no response to icariin treatment
Oshima et al., Am J Physiol Cell Physiol 2008 (Stomach Neoplasms) : Both aspirin mediated permeability and phosphorylation of p38 MAPK were significantly attenuated by SB-203580 ( a p38 MAPK inhibitor ) but not by U-0126 ( a MEK1 inhibitor ) or SP-600125 ( a JNK inhibitor )
Goleva et al., Am J Respir Cell Mol Biol 2009 : The presence of the p38 MAPK inhibitor, SB203580, or IFN-gamma inhibited p38 MAPK phosphorylation and enhanced GCRalpha nuclear translocation in response to DEX
Lavoie et al., Equine Vet J 2008 (Horse Diseases...) : It has been suggested that many of the beneficial effects of corticosteroids are mediated through mitogen activated protein kinase ( MAPK ) p38 inhibition
Wu et al., Free Radic Biol Med 2009 (MAP Kinase Signaling System) : Activation of JNK and p38MAPK was weaker in TNFalpha plus PY-treated NOS2 ( -/- ) mice and 1400W and NAC blocked the activation of JNK and p38MAPK in wild-type mice
Han et al., Mol Cancer Res 2009 (Carcinoma...) : Taken together, these findings show that fish oil inhibits ILK expression through activation of PPARgamma mediated and p38 mitogen activated protein kinase mediated induction of AP-2alpha
Langlois et al., J Leukoc Biol 2009 (Asthma) : ERK-1/2 and p38 modulate CD11b expression ; ERK-1/2 is also involved in long-term MMP-9 secretion and p38 in the plasmin activation system
Sheng et al., J Neuroimmune Pharmacol 2009 (MAP Kinase Signaling System) : IL-1beta triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways, but WIN55,212-2 mainly inhibited p38 MAPK phosphorylation
Nencioni et al., J Biol Chem 2009 : In infected Bcl-2 ( + ) cells, activated p38MAPK was found predominantly in the cytoplasm, colocalized with Bcl-2, and both Bcl-2 phosphorylation and virally induced apoptosis were diminished by specific inhibition of p38MAPK activity
King et al., J Biol Chem 2009 : Similarly, NF-kappaB dependent transcription is significantly reduced to levels consistent with maximal p38 MAPK inhibition
Yang et al., Naunyn Schmiedebergs Arch Pharmacol 2009 : Doxazosin or TGF-beta1 alone respectively elevated p38 mitogen activated protein kinases ( MAPK ) and Smad3 protein phosphorylation in H9C2 cells
Su et al., J Mol Biol 2010 (MAP Kinase Signaling System) : Collectively, our data reveal that excessive TRPM7 channel activity causes oxidative and nitrosative stresses, producing cell rounding mediated by p38 MAPK/JNK dependent activation of m-calpain
Pozsgai et al., Int J Cancer 2010 (Brain Neoplasms...) : A major decrease in the levels of phospho-Akt, phospho-GSK3ß and phosho-ERK 1/2 was detected at 5 and 10 min following treatment with the GHRH antagonists, whereas elevated levels of phospho-p38 were observed at 24 hr
Campbell et al., Int J Biochem Cell Biol 2011 : We conducted a study of p38 MAPK phosphorylation during liver regeneration in mice to determine whether p38 MAPK activation or inactivation may correlate with events that lead to DNA replication after partial hepatectomy ( PH ), and whether p38 MAPK activation may be required for hepatocyte DNA replication in vivo and in culture
Persichini et al., Neurosci Lett 2010 : Moreover, we have observed that IL-1ß regulates the expression of Cp and Fpn genes through ( i ) p38 MAPK mediated activation of C/EBP transcription factor, ( ii ) ERK1/2-, JNK1- and partially p38 MAPK dependent activation of AP-1, and through ( iii ) activation of NF-?B partially mediated by p38 MAPK
Kerkelä et al., Am J Physiol Regul Integr Comp Physiol 2011 : Stretching of isolated atria induced a rapid increase in phosphorylation of p38 MAPK and ERK and induced a p38 MAPK dependent increase in DNA binding activity of transcription factors Elk-1 and GATA-4
Eda et al., Rheumatol Int 2011 (MAP Kinase Signaling System) : These results showed that proinflammatory cytokines, IL-1ß and TNF-a, induced the expression of IL-34 mRNA via JNK and p44/42 MAPK but not p38 in human osteoblasts while p38, JNK, and p44/42 MAPK were not involved in the induction of M-CSF mRNA expression by these cytokines
Lee et al., Horm Metab Res 2011 : In the present study, the relationships between NIS, CHOP, and p38 MAPK, and the effects of ATRA on NIS and CHOP expression as well as on p38 MAPK activation under condition of ER stress in thyroid cells were investigated
Carchman et al., Hepatology 2011 (Liver Diseases) : Sepsis or LPS induced autophagy protects against hepatocellular death, in part via an HO-1 p38 MAPK dependent signaling
Deraz et al., PloS one 2011 (Carcinoma, Squamous Cell...) : These results suggest that MMP-10 plays an important role in the invasion and metastasis of HNSCC, and that invasion driven by MMP-10 is partially associated with p38 MAPK inhibition
Pang et al., Biochim Biophys Acta 2012 (Inflammation) : We provide novel evidence demonstrating that the anti-inflammatory effects of minocycline in human monocytes include, in addition to decreased NF-?B activation, abrogation of the LPS stimulated LOX-1, LITAF, Nur77 pathways, p38 MAPK inhibition and PI3K/Akt activation
Chu et al., Can J Neurol Sci 2012 (Disease Models, Animal...) : Here we demonstrate that ( 1 ) both HS014 and SB203580 reduced CCI reduced hyperalgesia ( 2 ) p-p38MAPK was increased after CCI with a time course parallel to that of the MC4R change, ( 3 ) The p38 activation was prevented by blocking MC4R with an antagonist HS014, but MC4R-IR was not prevented by SB203580
Bebien et al., PLoS Pathog 2012 (Streptococcal Infections) : The pore forming toxin ß hemolysin/cytolysin triggers p38 MAPK dependent IL-10 production in macrophages and inhibits innate immunity
Park et al., J Radiat Res 2012 (Neovascularization, Pathologic) : The radio-resistance of HHSECs was related to adenosine monophosphate activated protein kinase and p38 mitogen activated protein kinase mediated expression of MMP-2 and VEGFR-2, whereas the increased radio-sensitivity of HDMECs was related to extracellular signal regulated kinase mediated generation of angiostatin
Rolas et al., Hepatology 2013 (Escherichia coli Infections...) : Rapamycin also inhibited the RB of healthy PMNs, which was associated with impaired phosphorylation of the NOX2 component, p47phox ( phox : phagocyte oxidase ), on its mitogen activated protein kinase ( MAPK ) site ( S345 ) as well as a preferential inhibition of p38-MAPK relative to p44/42-MAPK
Xu et al., PloS one 2012 (Breast Neoplasms) : PIC induced activation of p38 MAPK and MK2 was attenuated by the PKR inhibitor and the PKR siRNA, but a selective p38 MAPK inhibitor ( SB203580 ) or other MAPK inhibitors did not affect PKR activity, indicating that PKR is upstream of p38 MAPK/MK2
Banerjee et al., Shock 2013 (Acute Lung Injury) : Despite this basal activation, hyperosmolar incubation attenuated TNF-a stimulated IL-8 release and ICAM-1 surface expression and subsequent PMN adherence, while p38 MAPK inhibition did not further influence the effects of hyperosmolar conditions on ICAM-1 surface expression
Kumar et al., J Environ Pathol Toxicol Oncol 2012 (Inflammation...) : When compared to hamsters bearing tumors that remained on the control diet, the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA, cyclin D1, and Bcl-2 ) and PCNA labelling index, ( 2 ) enhanced apoptosis ( increased Bax, caspase-3, caspase-9, and cytochrome c, and decreased survivin ) and apoptotic index, ( 3 ) decreased inflammation ( decreased Cox-2 ), and ( 4 ) decreased MAPK activation ( p-ERK and p-p38 )
Song et al., American journal of rhinology & allergy 2013 (Asthma) : Chitinase significantly activated the phosphorylation of p38 mitogen activated protein kinase ( MAPK ) but not the phosphorylation of extracellular signa-l related kinase ( ERK ) 1/2
Storm et al., PloS one 2013 : Through global transcriptional analysis and phosphorylation arrays, a strong ion flux dependent p38 MAPK response was detected and inhibition of p38 signaling delayed HAMLET induced death
Kim et al., Blood 2013 (HIV Infections) : Probing these pathways with RNA interference, pharmacological p38 MAPK inhibition , and in cell lines lacking STAT1s or the type I IFN receptor chain confirmed the role of MAPKKs and IRF7 in Tat mediated modulation of ISGs and excluded the involvement of IFNs in this modulation
Nagila et al., Virology journal 2013 : The p38 MAPK activation and TNF-a production were controlled by p38 MAPK and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK, TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells
Yang et al., Ann Hepatol 2013 (Cholelithiasis) : Expression of phosphorylated p38MAPK was upregulated by exogenous PGE2, and p38MAPK inhibitor reduced MUC2 and MUC5AC expression in HIBECs
Hazawa et al., FEBS open bio 2012 : VN attenuated radiation induced expression of p21, an inhibitor of cell cycle progression, and selectively inhibited Erk- and p38 MAPK dependent p21 induction after radiation exposure through regulation of the activity of GSK-3ß
Shrode et al., J Biol Chem 1997 : Cytosolic alkalinization increases stress activated protein kinase/c-Jun NH2-terminal kinase ( SAPK/JNK ) activity and p38 mitogen activated protein kinase activity by a calcium independent mechanism
Swantek et al., Mol Cell Biol 1997 : We confirm activation of the MAPK family members extracellular-signal regulated kinases 1 and 2 ( ERK1 and ERK2 ), p38 , and Jun N-terminal kinase/stress activated protein kinase ( JNK/SAPK ), as well as activation of the immediate upstream MAPK activators MAPK/ERK kinases 1 and 4 ( MEK1 and MEK4 )
Ridley et al., FEBS Lett 1998 : The mechanism by which p38 mitogen activated protein kinase ( MAPK ) regulates the induction of cyclooxygenase (COX)-2 by interleukin-1 (IL-1) has been investigated in HeLa cells
Wagner et al., Digestion 1999 (Pancreatitis) : Pancreatic expression of p38 Map kinase and MAPK , SAPK and p38 regulation during pancreatic stress were investigated