Gene interactions and pathways from curated databases and text-mining

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Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Menden et al., Am J Physiol Lung Cell Mol Physiol 2013 : LPS increased PP2A activity in HPMEC, and inhibition of PP2A did not alter LPS mediated ICAM-1 expression but attenuated IKK-ß phosphorylation
Fu et al., J Biol Chem 2003 : Our data support the notion that IKK gamma associated PP2A is responsible for the rapid deactivation of IKK, and inhibition of PP2A by Tax in the context of IKK x PP2A x Tax ternary complex leads to constitutive IKK and NF-kappa B activation
Abolhassani et al., Inflamm Res 2008 (Inflammation) : We demonstrated the induction of IKK gamma after methylation and activation of PP2A
Kray et al., J Biol Chem 2005 (Inflammation) : Prior in vitro mixing experiments indicate that protein serine/threonine phosphatase 2A (PP2A) can dephosphorylate these T loop serines and inactivate IKK, suggesting a negative regulatory role for PP2A in IKK signaling ... Here we provided several in vivo lines of evidence indicating that PP2A plays a positive rather than a negative role in the regulation of IKK