◀ Back to NFKB1
NFKB1 — PPP2R2B
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Fu et al., J Biol Chem 2003
:
Our data support the notion that IKK gamma associated PP2A is responsible for the rapid deactivation of IKK, and inhibition of
PP2A by Tax in the context of IKK x PP2A x Tax ternary complex
leads to constitutive IKK and
NF-kappa B activation
Hong et al., J Biol Chem 2007
:
Interestingly, peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and
IKKgamma-PP2A interactions and potently
inhibit NF-kappaB activation by Tax and tumor necrosis factor-alpha
Marasa et al., Am J Physiol Cell Physiol 2008
:
The present study tests the hypothesis that induced TRPC1 expression
inhibits NF-kappaB activation by increasing
PP2A activity through Ca2+ influx in IECs ... Inhibition of
PP2A activity by treatment with okadaic acid or PP2A silencing with small interfering RNA not only
enhanced NF-kappaB transactivation but also prevented the increased susceptibility of IEC-TRPC1 cells to apoptosis induced by treatment with tumor necrosis factor-alpha (TNF-alpha)/cycloheximide ( CHX ) ... Decreasing Ca2+ influx by exposure to the Ca2+-free medium reduced
PP2A mRNA levels, destabilized PP2A proteins, and
induced NF-kappaB activation, thus blocking the increased sensitivity of IEC-TRPC1 cells to TNF-alpha/CHX induced apoptosis
Nho et al., J Biol Chem 2011
:
Furthermore ectopic expression of PP2A, or PP2A silencing using PP2A siRNA confirmed that
4EBP-1 is
regulated by
PP2A
Sontag et al., EMBO J 1997
:
Constitutive
activation of PKC zeta and
NF-kappaB following inhibition of
PP2A supports new mechanisms by which SV40 small t promotes cell growth and transformation